Class II histone deacetylases: versatile regulators.

[en] Histone acetylation and deacetylation play essential roles in modifying chromatin structure and regulating gene expression in eukaryotes. Histone deacetylases (HDACs) catalyze the deacetylation of lysine residues in the histone N-terminal tails and are found in large multiprotein complexes with transcriptional co-repressors. Human HDACs are grouped into three classes based on their similarity to known yeast factors: class I HDACs are similar to the yeast transcriptional repressor yRPD3, class II HDACs to yHDA1 and class III HDACs to ySIR2. In this review, we focus on the biology of class II HDACs. These newly discovered enzymes have been implicated as global regulators of gene expression during cell differentiation and development. We discuss their emerging biological functions and the molecular mechanisms by which they are regulated.

Disciplines :

Biochemistry, biophysics & molecular biology

Author, co-author :

Verdin, Eric

Dequiedt, Franck ; Université de Liège - ULiège > GIGA-Research - Centre de Bio. Fond. - Section de Biologie cell. et moléc.

Kasler, Herbert G

Language :

English

Title :

Class II histone deacetylases: versatile regulators.

Publication date :

2003

Journal title :

Trends in Genetics

ISSN :

0168-9525

eISSN :

1362-4555

Publisher :

Elsevier Trends Journals, Cambridge, United Kingdom

Volume :

Issue :

Pages :

286-93

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 04 January 2011

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953 (1 by ULiège)

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Scopus citations^®

562

Scopus citations^®
without self-citations

543

OpenCitations

495

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