colic; enoxaparin; fractionated heparin; horses; postoperative intensive care
Abstract :
[en] Objectives – The aim of this study is to describe the prevalence of postoperative laminitis in colic cases and to
determine if low-molecular-weight heparin (LMWH) is effective in preventing this complication.
Design – Retrospective clinical study.
Animals – Client-owned horses.
Interventions – SC administration of enoxaparin during the postoperative period.
Measurements and Main Results – Medical records of 360 horses undergoing surgery for colic and surviving
at least 3 days were evaluated. Fifty-six horses admitted before 1995 did not receive LMWH (control group)
and 304 admitted after 1995 received LMWH as a prophylaxis for laminitis (treatment group). Three grades of
severity were defined for laminitis. Prevalence and severity of laminitis were compared between the 2 groups.
Several parameters recorded on admission (sex, age, breed, site and nature of the disease, heart rate, PCV,
gravity score, and shock score) and the administration of LMWH were tested as risk factors in the
development of laminitis in a logistic regression procedure. Prevalence and grade of laminitis were
significantly lower in the treatment group. Only the absence of LMWH was recognized as a significant risk
factor in the logistic regression model.
Conclusions – The administration of LMWH appears to be effective in the prophylaxis of laminitis following
colic surgery and may be useful in the postoperative management of these horses.
Research center :
CORD - Centre de l'Oxygène, Recherche et Développement - ULiège Clinique Vétérinaire universitaire, pôle équin, chirurgie et anesthésie des grands animaux
Disciplines :
Veterinary medicine & animal health
Author, co-author :
de la Rebière de Pouyade, Geoffroy ; Université de Liège - ULiège > Département clinique des animaux de compagnie et des équidés > Anesthésiologie gén. et pathologie chirurg. des grds animaux
Grulke, Sigrid ; Université de Liège - ULiège > Département clinique des animaux de compagnie et des équidés > Département clinique des animaux de compagnie et des équidés
Detilleux, Johann ; Université de Liège - ULiège > Département de productions animales > Génétique quantitative - Epidémiologie et santé publique
Salciccia, Alexandra ; Université de Liège - ULiège > Département clinique des animaux de compagnie et des équidés > Département clinique des animaux de compagnie et des équidés
Verwilghen, Denis ; Université de Liège - ULiège > Département clinique des animaux de compagnie et des équidés > Anesthésiologie gén. et pathologie chirurg. des grds animaux
Caudron, Isabelle
Gangl, Monica
Serteyn, Didier ; Université de Liège - ULiège > Département clinique des animaux de compagnie et des équidés > Anesthésiologie gén. et pathologie chirurg. des grds animaux
Language :
English
Title :
Evaluation of low-molecular-weight heparin for the prevention of equine laminitis after colic surgery
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