Deletion of the 5'-ABL region: a recurrent anomaly detected by fluorescence in situ hybridization in about 10% of Philadelphia-positive chronic myeloid leukaemia patients.
Adult; Aged; Aged, 80 and over; DNA Probes; Female; Fusion Proteins, bcr-abl/genetics; Gene Deletion; Humans; In Situ Hybridization, Fluorescence; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/genetics; Male; Middle Aged; Philadelphia Chromosome
Abstract :
[en] Inclusion of the BCR-ABL ES probe in routine cytogenetics led to the identification of a subgroup of Philadelphia positive (Ph+) chronic myeloid leukaemia patients characterized by a 5'-ABL deletion. This anomaly was observed in 5/51 cases (9.8%). Cytological and clinical data suggest that the 5'-ABL deletion may be associated with dysplastic features of polymorphonuclear cells and metamyelocytes and a short chronic phase duration.
Disciplines :
Hematology
Author, co-author :
Herens, Christian ; Centre Hospitalier Universitaire de Liège - CHU > Génétique
Tassin, Françoise ; Centre Hospitalier Universitaire de Liège - CHU > Hématologie biologique et immuno hématologie
Lemaire, Véronique ; Centre Hospitalier Universitaire de Liège - CHU > Salles urgences NDB
Beguin, Yves ; Centre Hospitalier Universitaire de Liège - CHU > Hématologie clinique
Collard, E.
Lampertz, S.
Croisiau, C.
Desouter-Lecomte, Michèle ; Université de Liège - ULiège > Département de chimie (sciences) > Laboratoire de chimie physique théorique
Koulischer, Lucien ; Université de Liège - ULiège > Relations académiques et scientifiques (Médecine)
Language :
English
Title :
Deletion of the 5'-ABL region: a recurrent anomaly detected by fluorescence in situ hybridization in about 10% of Philadelphia-positive chronic myeloid leukaemia patients.
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