Article (Scientific journals)
Soluble transferrin receptor as a potential determinant of iron loading in congenital anaemias due to ineffective erythropoiesis.
Cazzola, M.; Beguin, Yves; Bergamaschi, G. et al.
1999In British Journal of Haematology, 106 (3), p. 752-5
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Keywords :
Adolescent; Adult; Aged; Anemia, Dyserythropoietic, Congenital/genetics/metabolism; Anemia, Sideroblastic/genetics/metabolism; Child; Erythropoiesis/genetics/physiology; Heterozygote; Humans; Iron Overload/genetics/metabolism; Middle Aged; Mutation/genetics; Receptors, Transferrin/genetics/metabolism; beta-Thalassemia/genetics/metabolism
Abstract :
[en] Congenital anaemias due to ineffective erythropoiesis may be associated with excessive iron absorption and progressive iron loading. We investigated whether the soluble transferrin receptor (TfR) level was related to the degree of iron overload in 20 patients with thalassaemia intermedia, six patients with congenital dyserythropoietic anaemia type II (CDA II) and four patients with X-linked congenital sideroblastic anaemia (XLSA). All but two patients had increased serum ferritin levels (median 601 microgram/l, range 105-2855 microgram/l). Multiple regression analysis showed that 62% (P < 0.0001) of the variation in serum ferritin was explained by age and by changes in soluble TfR.
Disciplines :
Hematology
Author, co-author :
Cazzola, M.
Beguin, Yves  ;  Centre Hospitalier Universitaire de Liège - CHU > Hématologie clinique
Bergamaschi, G.
Guarnone, R.
Cerani, P.
Barella, S.
Cao, A.
Galanello, R.
Language :
English
Title :
Soluble transferrin receptor as a potential determinant of iron loading in congenital anaemias due to ineffective erythropoiesis.
Publication date :
1999
Journal title :
British Journal of Haematology
ISSN :
0007-1048
eISSN :
1365-2141
Publisher :
Blackwell Publishing, Oxford, United Kingdom
Volume :
106
Issue :
3
Pages :
752-5
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 09 March 2009

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