Matched unrelated donor stem cell transplant in 131 patients with follicular lymphoma : an analysis from the Lymphoma Working Party of the European Group for Blood and Marrow Transplantation
Avivi, Irit; Montoto, Silvia; Canals, Carmeet al.
2009 • In British Journal of Haematology, 147, p. 719-728
[en] Matched unrelated donor stem cell transplantation (MUD-SCT) provides the only curative option for patients with follicular lymphoma (FL) who fail conventional therapies and do not have a siblong donor. The purpose of this study was to analyse the outcome of patients with FL treated with MUD-SCT included in the European Group for Blood and Marrow Transplantation registry. 131 patients treated with reduced-intensity conditioning (RIC, n=87) or conventional myeloablative (CONV, n=44) MUD-SCT between 2000 and 2005 were included. Median time from diagnosis to MUD-SCT was 47 months and the median number of previous therapeutic regimens was 4 (previous autograft : 47%). RIC recipients were significantly older, with a longer interval from diagnosis to MUD-SCT and had failed a previous autograft more frequently than CONV recipients. Non-relapse mortality (NRM) was 24% and 30% at 100-d and 1-year, respectively. After a median follow-up of 36 months, 17% of the patients developed disease progression, the 3-year progression-freee survival (PFS) being 47%. Three-year overall survival (OS) for the whole series was 51%. On multivariate analysis, RIC regimens were associated with at lower NRM and a significantly longer PFS and OS. This retrospective study demonstrated that MUS-SCT results, even in heavily pre-treated populations, in a meaningful PFS and OS
Disciplines :
Hematology
Author, co-author :
Avivi, Irit; Rambam Medical Centre and Technion (Haifa, Israel)
Montoto, Silvia; St Bartholomew’s Hospital (London, UK)
Canals, Carme; Hospital de Sant Pau (Barcelona, Spain)
Maertens, John; University Hospital Gasthuisberg (Leuven, Belgium)
Al-Ali, Haifa; University Hospital Leipzig (Leipzig, Germany)
Mufti, Ghulam J.; GKT School of Medicine (London, UK)
Finke, Jürgen; University of Freiburg (Freiburg, Germany)
Schattenberg, Anton; Radboud University – Nijmegen Medical Centre (Nijmegen, The Netherlands)
Fanin, Renato; University Hospital (Udine, Italy)
Cornelissen, Jan J.; Erasmus MC-Daniel den Hoed Cancer Centre (Rotterdam, The Netherlands)
Vernant, Jean-Paul; Groupe Hospitalier Pitié-Salpêtrière (Paris, France)
Russel, Nigell; Nottingham City Hospital (Nottingham, UK)
Matched unrelated donor stem cell transplant in 131 patients with follicular lymphoma : an analysis from the Lymphoma Working Party of the European Group for Blood and Marrow Transplantation
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