Article (Scientific journals)
Impairment of renal function with increasing blood lead concentrations in the general population
Staessen, Jan; Lauwerys, Robert; Buchet, Jean-Pierre et al.
1992In New England Journal of Medicine, 327 (3), p. 151-156
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Keywords :
Renal function; Cadmium; environmental exposure
Abstract :
[en] Cadmium and lead are toxic to the kidney. Both metals are known to induce nephropathy in subjects with heavy exposure. Environmental exposure to cadmium is associated with renal tubular dysfunction, but few studies have attempted to evaluate the renal effects of environmental lead exposure. A weak positive correlation between serum creatinine and blood lead concentrations was found in men, but not women, in the British civil service. We investigated the relation between lead exposure and renal function in the general population, using data obtained during the Cadmibel (Cadmium in Belgium) Study. Lead exposure was estimated by measuring blood concentrations of lead and zinc protoporphyrin, which is increased in the presence of high lead levels.
Disciplines :
Urology & nephrology
Author, co-author :
Staessen, Jan;  Katholieke Universiteit Leuven - KUL > Pathophysiology > Hypertension and Cardiovascular Rehabilitation Unit
Lauwerys, Robert;  Université Catholique de Louvain - UCL > Industrial Toxicology and Occupational Medicine Unit
Buchet, Jean-Pierre;  Université Catholique de Louvain - UCL > Industrial Toxicology and Occupational Medicine Unit
Bulpitt, Christopher;  Katholieke Universiteit Leuven - KUL > Pathophysiology > Hypertension and Cardiovascular Rehabilitation Unit
Rondia, Désiré;  Université de Liège - ULiège > Environmental Toxicology Unit
Vanrenterghem, Yves
Amery, Antoon;  Katholieke Universiteit Leuven - KUL > Pathophysiology > Hypertension and Cardiovascular Rehabilitation Unit
Saint-Remy, Annie ;  Université de Liège - ULiège > Département des sciences cliniques > Néphrologie
The Cadmibel Study Group
Language :
English
Title :
Impairment of renal function with increasing blood lead concentrations in the general population
Publication date :
16 July 1992
Journal title :
New England Journal of Medicine
ISSN :
0028-4793
eISSN :
1533-4406
Publisher :
Massachusetts Medical Society, Waltham, United States - Massachusetts
Volume :
327
Issue :
3
Pages :
151-156
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 22 December 2010

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