[en] Objective To prenatally identify pregnant women at risk of developing congenital infection due to human
cytomegalovirus (HCMV).
Methods One thousand one hundred and thirty-one pregnant women from three municipalities from Havana
City were serologically screened for HCMV infection (IgM/IgG, IgG avidity) from January 2007 to January
2008. Demographical, epidemiological, and clinical variables were correlated to serologic status to identify
predictors of seroconversion in pregnancy.
Results The majority of women were seropositive to HCMV (92.6%); 27 women (2.4%) developed HCMV
active infection during pregnancy, defined by the detection of IgG+ and IgM+ (7 women), IgM+ and IgG−
(2 women), and IgG seroconversion (18 women). Susceptibility of active HCMV infection during pregnancy
was associated with maternal age <20 years and nulligravidity. Primary infection was detected in 20 pregnant
women (1.8%), whereas 7 patients (0.6%) had active non-primary infection.
Conclusion Although pregnant women in Cuba have high seroprevalence rates for HCMV, those younger
than 20 years and nulligravidae are at risk of acquiring infection during pregnancy.
Disciplines :
Immunology & infectious disease
Author, co-author :
Correa, C. B.; Institute of Tropical Medicine Pedro Kouri, Havana City, Cuba > Virology Department
Kouri, V.; Institute of Tropical Medicine Pedro Kouri, Havana City, Cuba > Virology Department
Verdasquera, D.; Institute of Tropical Medicine Pedro Kouri, Havana City, Cuba > Virology Department
Martinez, P. A.; Institute of Tropical Medicine Pedro Kouri, Havana City, Cuba > Virology Department
Alvarez, A.; Institute of Tropical Medicine Pedro Kouri, Havana City, Cuba > Virology Department
Aleman, Y.; Institute of Tropical Medicine Pedro Kouri, Havana City, Cuba > Virology Department
Perez, L.; Institute of Tropical Medicine Pedro Kouri, Havana City, Cuba > Virology Department
Viera, J.; Institute of Tropical Medicine Pedro Kouri, Havana City, Cuba > Virology Department
Gonzalez, R.; Institute of Tropical Medicine Pedro Kouri, Havana City, Cuba > Virology Department
Perez, E.; Genetics Department of Municipalities: Regla, Old Havana, Central Havana, Cuba
Moro, I.; Genetics Department of Municipalities: Regla, Old Havana, Central Havana, Cuba
Navarro, M. A.; Genetics Department of Municipalities: Regla, Old Havana, Central Havana, Cuba
Melin, Pierrette ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Microbiologie médicale et virologie médicale
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