Article (Scientific journals)
Interactions medicamenteuses: de la theorie a la pratique.
Scheen, André
2006In Revue Médicale de Liège, 61 (5-6), p. 471-82
Peer reviewed
 

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Keywords :
Cytochrome P-450 Enzyme System/physiology; Drug Interactions; Drug Therapy; Humans
Abstract :
[en] Pharmacotherapy becomes increasingly complex and therapeutic targets are more and more ambitious for both care and prevention. Therefore, polypharmacy is frequent, which exposes the patient to a high risk of drug-drug interactions. These are often underestimated although they are responsible for many adverse events that may be serious and even fatal. In the present paper, we will first briefly recall the main cautions in the use of medications as well as the most common conditions favouring the occurrence of harmful drug interactions. Then, we will analyze the various mechanisms leading to drug interactions, emphasizing especially those involving cytochrome P450 enzymatic system and P-glycoprotein. Finally, we will illustrate these theoretical considerations with some examples of drug interactions, among the most dangerous and the most frequent in clinical practice.
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Scheen, André  ;  Université de Liège - ULiège > Département des sciences cliniques > Diabétologie, nutrition et maladie métaboliques - Médecine interne générale
Language :
French
Title :
Interactions medicamenteuses: de la theorie a la pratique.
Alternative titles :
[en] Drug interactions: from theory to practice
Publication date :
2006
Journal title :
Revue Médicale de Liège
ISSN :
0370-629X
eISSN :
2566-1566
Publisher :
Université de Liège. Revue Médicale de Liège, Liège, Belgium
Volume :
61
Issue :
5-6
Pages :
471-82
Peer reviewed :
Peer reviewed
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since 05 March 2009

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