Reference : Differentiating muscle damage from myocardial injury by meaans of the serum creatinin...
Scientific journals : Article
Human health sciences : Laboratory medicine & medical technology
Differentiating muscle damage from myocardial injury by meaans of the serum creatinine kinase (CK) isoenzyme MB mass measurement/total CK activity ratio
el Allaf, M. [ > > ]
Chapelle, Jean-Paul mailto [Université de Liège - ULiège > Département de pharmacie > Chimie médicale >]
El Allaf, Dia [Université de Liège - ULiège > > Cardiologie >]
Adam, A. [ > > ]
Faymonville, Marie-Elisabeth mailto [Université de Liège - ULiège > > Anesthésie et réanimation >]
Laurent, P. [ > > ]
Heusghem, C. [ > > ]
Clinical Chemistry
American Association for Clinical Chemistry
Yes (verified by ORBi)
[en] We immunoenzymometrically measured creatine kinase (CK) isoenzyme MB in extracts of myocardium and in homogenates of five different skeletal muscles. CK-MB concentrations in the former averaged 80.9 micrograms/g wet tissue; in the skeletal muscles it varied widely, being (e.g.) 25-fold greater in diaphragm than in psoas. CK-MB in skeletal muscles ranged from 0.9 to 44 ng/U of total CK; the mean for myocardium was 202 ng/U. In sera from 10 trauma and 36 burn patients without myocardial involvement, maximum ratios for CK-MB mass/total CK activity averaged 7 (SEM 1) ng/U and 18 (SEM 6) ng/U, respectively. Except for an infant (220 ng/U), the highest ratio we found for serum after muscular damage was 38 ng/U. In contrast, the mean maximum ratio determined in 23 cases of acute myocardial infarction exceeded 200 ng/U. Among seven determinations performed 8 to 32 h after onset of symptoms, each infarct patient demonstrated at least one ratio greater than or equal to 110 ng/U. Ratios observed after infarct were unrelated to treatment received during the acute phase. We propose a CK-MB/total CK ratio of 80 ng/U as the cutoff value for differentiating myocardial necrosis from muscular injury.

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