[en] The technique of X-ray diffraction has been successfully applied to enzymes associated with peptidoglycan biosynthesis. The technique has taught us a great deal about the structures and catalytic mechanisms of penicillin-binding proteins and beta-lactamases. An insight into the structural basis for antibiotic resistance is given.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Kelly, J. A.
Kuzin, A. P.
Charlier, Paulette ; Université de Liège - ULiège > Département des sciences de la vie > Cristallographie des macromolécules biologiques
Fonze, E.
Language :
English
Title :
X-ray studies of enzymes that interact with penicillins.
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