Organ failure and tight glycemic control in the SPRINT study.

[en] INTRODUCTION: Intensive care unit mortality is strongly associated with organ failure rate and severity. The sequential organ failure assessment (SOFA) score is used to evaluate the impact of a successful tight glycemic control (TGC) intervention (SPRINT) on organ failure, morbidity, and thus mortality. METHODS: A retrospective analysis of 371 patients (3,356 days) on SPRINT (August 2005 - April 2007) and 413 retrospective patients (3,211 days) from two years prior, matched by Acute Physiology and Chronic Health Evaluation (APACHE) III. SOFA is calculated daily for each patient. The effect of the SPRINT TGC intervention is assessed by comparing the percentage of patients with SOFA 2) are also compared. Cumulative time in 4.0 to 7.0 mmol/L band (cTIB) was evaluated daily to link tightness and consistency of TGC (cTIB >/=0.5) to SOFA /=0.5 (37% Pre-SPRINT) reaching 100% by Day 7 (50% Pre-SPRINT). Conditional and joint probabilities indicate tighter, more consistent TGC under SPRINT (cTIB >/=0.5) increased the likelihood SOFA /=0.5 metric provides a first benchmark linking TGC quality to organ failure. These results support other physiological and clinical results indicating the role tight, consistent TGC can play in reducing organ failure, morbidity and mortality, and should be validated on data from randomised trials.

Disciplines :

Anesthesia & intensive care

Author, co-author :

Chase, J Geoffrey

Pretty, Christopher G

Pfeifer, Leesa

Shaw, Geoffrey M

Preiser, Jean-Charles ; Centre Hospitalier Universitaire de Liège - CHU > Soins intensifs

Le Compte, Aaron J

Lin, Jessica

Hewett, Darren

Moorhead, Katherine ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, humaines et path. - Thermodynamique des phénomènes irréversibles

Desaive, Thomas ; Université de Liège - ULiège > Département d'astrophys., géophysique et océanographie (AGO) > Thermodynamique des phénomènes irréversibles - Département d'astrophys., géophysique et océanographie (AGO)

Language :

English

Title :

Organ failure and tight glycemic control in the SPRINT study.

Publication date :

2010

Journal title :

Critical Care

ISSN :

1364-8535

eISSN :

1466-609X

Publisher :

BioMed Central, London, United Kingdom

Volume :

Issue :

Pages :

R154

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 28 November 2010

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Scopus citations^®

115

Scopus citations^®
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OpenAlex citations

130

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