Barratt G, Saint-Pierre-Chazalet M, Loiseau PM (2009) Cellular transport and lipid interactions of miltefosine. Curr Drug Metab 10:247-55
Bäumer W, Wlaz P, Jennings G et al. (2010) The putative lipid raft modulator miltefosine displays immunomodulatory action in T-cell dependent dermal inflammation models. Eur J Pharmacol 628:226-32
Brint EK, Xu D, Liu H et al. (2004) ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance. Nat Immunol 5:373-9
Caceres M, Tobar N, Guerrero J et al. (2008) c-jun-NH2JNK mediates invasive potential and EGFR activation by regulating the expression of HB-EGF in a urokinase-stimulated pathway. J Cell Biochem 103:986-93
D'Alessio S, Gerasi L, Blasi F (2008) uPAR-deficient mouse keratinocytes fail to produce EGFR-dependent laminin-5, affecting migration in vivo and in vitro. J Cell Sci 121:3922-32
Dölle S, Hoser D, Rasche C et al. (2010) Long-term reduction in local inflammation by a lipid raft molecule in atopic dermatitis. Allergy 65:1158-65
Fartasch M, Bassukas ID, Diepgen TL (1992) Disturbed extruding mechanism of lamellar bodies in dry non-eczematous skin of atopics. Br J Dermatol 127:221-7
Fuhrman B, Nitzan O, Karry R et al. (2007) Urokinase plasminogen activator (uPA) stimulates cholesterol biosynthesis in macrophages through activation of SREBP-1 in a PI3-kinase and MEK-dependent manner. Atherosclerosis 195:e108-16
Gniadecki R, Bang B (2003) Flotillas of lipid rafts in transit amplifying cell-like keratinocytes. J Invest Dermatol 121:522-8
Guttman-Yassky E, Suarez-Farinas M, Chiricozzi A et al. (2009) Broad defects in epidermal cornification in atopic dermatitis identified through genomic analysis. J Allergy Clin Immunol 124:1235-44 e1258
Howell MD, Kim BE, Gao P et al. (2007) Cytokine modulation of atopic dermatitis filaggrin skin expression. J Allergy Clin Immunol 120:150-5
Jans R, Atanasova G, Jadot M et al. (2004) Cholesterol depletion upregulates involucrin expression in epidermal keratinocytes through activation of p38. J Invest Dermatol 123:564-73
Jarzab J, Filipowska B, Zebracka J et al. (2010) Locus 1q21 Gene expression changes in atopic dermatitis skin lesions: deregulation of small proline-rich region 1A. Int Arch Allergy Immunol 151:28-37
Kabouridis PS, Janzen J, Magee AL et al. (2000) Cholesterol depletion disrupts lipid rafts and modulates the activity of multiple signaling pathways in T lymphocytes. Eur J Immunol 30:954-63
Kiyan J, Smith G, Haller H et al. (2009) Urokinase-receptor-mediated phenotypic changes in vascular smooth muscle cells require the involvement of membrane rafts. Biochem J 423:343-51
Klein U, Gimpl G, Fahrenholz F (1995) Alteration of the myometrial plasma membrane cholesterol content with beta-cyclodextrin modulates the binding affinity of the oxytocin receptor. Biochemistry 34:13784-93
Lambert S, Ameels H, Gniadecki R et al. (2008) Internalization of EGF receptor following lipid rafts disruption in keratinocytes is delayed and dependent on p38 MAPK activation. J Cell Physiol 217:834-45
Lambert S, Vind-Kezunovic D, Karvinen S et al. (2006) Ligand-independent activation of the EGFR by lipid raft disruption. J Invest Dermatol 126:954-62
Lange Y, Ye J, Steck TL (2004) How cholesterol homeostasis is regulated by plasma membrane cholesterol in excess of phospholipids. Proc Natl Acad Sci USA 101:11664-7
Lu ZR, Park D, Lee KA et al. (2009) Profiling the dysregulated genes of keratinocytes in atopic dermatitis patients: cDNA microarray and interactomic analyses. J Dermatol Sci 54:126-9
Mathay C, Giltaire S, Minner F et al. (2008) Heparin-binding EGF-like growth factor is induced by disruption of lipid rafts and oxidative stress in keratinocytes and participates in the epidermal response to cutaneous wounds. J Invest Dermatol 128:717-27
Mathay C, Poumay Y (2010) Lipid rafts and the oxidative stress hypothesis. J Invest Dermatol 130:1457-9
Menon GK (2003) Caveolins in epidermal lamellar bodies: skin is an interactive interface, not an inflexible barrier. J Invest Dermatol 120:xv-i
Minner F, Herphelin F, Poumay Y (2010) Study of epidermal differentiation in human keratinocytes cultured in autocrine conditions. Methods Mol Biol 585:71-82
Oyoshi MK, He R, Kumar L et al. (2009) Cellular and molecular mechanisms in atopic dermatitis. Adv Immunol 102:135-226
Palmer CN, Irvine AD, Terron-Kwiatkowski A et al. (2006) Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis. Nat Genet 38: 441-6
Pike LJ (2006) Rafts defined: a report on the keystone symposium on lipid rafts and cell function. J Lipid Res 47:1597-8
Pike LJ (2009) The challenge of lipid rafts. J Lipid Res 50(Suppl):S323-8
Ragno P (2006) The urokinase receptor: a ligand or a receptor? Story of a sociable molecule. Cell Mol Life Sci 63:1028-37
Roelandt T, Giddelo C, Heughebaert C et al. (2009) The "caveolae brake hypothesis" and the epidermal barrier. J Invest Dermatol 129:927-36
Roupé KM, Nybo M, Sjobring U et al. (2010) Injury is a major inducer of epidermal innate immune responses during wound healing. J Invest Dermatol 130:1167-77
Saaf AM, Tengvall-Linder M, Chang HY et al. (2008) Global expression profiling in atopic eczema reveals reciprocal expression of inflammatory and lipid genes. PLoS One 3:e4017
Sahores M, Prinetti A, Chiabrando G et al. (2008) uPA binding increases UPAR localization to lipid rafts and modifies the receptor microdomain composition. Biochem Biophys Acta 1778:250-9
Sando GN, Zhu H, Weis JM et al. (2003) Caveolin expression and localization in human keratinocytes suggest a role in lamellar granule biogenesis. J Invest Dermatol 120:531-41
Shi L, Jones WD, Jensen RV et al. (2008) The balance of reproducibility, sensitivity, and specificity of lists of differentially expressed genes in microarray studies. BMC Bioinformatics 9(Suppl 9):S10
Simons K, Toomre D (2000) Lipid rafts and signal transduction. Nat Rev Mol Cell Biol 1:31-9
Sitrin RG, Johnson DR, Pan PM et al. (2004) Lipid raft compartmentalization of urokinase receptor signaling in human neutrophils. Am J Respir Cell Mol Biol 30:233-41
Sugiura H, Ebise H, Tazawa T et al. (2005) Large-scale DNA microarray analysis of atopic skin lesions shows overexpression of an epidermal differentiation gene cluster in the alternative pathway and lack of protective gene expression in the cornified envelope. Br J Dermatol 152:146-9
Voegeli R, Rawlings AV, Breternitz M et al. (2009) Increased stratum corneum serine protease activity in acute eczematous atopic skin. Br J Dermatol 161:70-7
Weller K, Artuc M, Jennings G et al. (2009) Miltefosine inhibits human mast cell activation and mediator release both in vitro and in vivo. J Invest Dermatol 129:496-8
Wertz PW, Michniak BB (2000) Epidermal lipid metabolism and barrier function of stratum corneum. In: Biochemical Modulation of Skin Reactions (Kydonieus AF, Wille JJ, eds). CRC Press, 35-44
Wu Z, Hansmann B, Meyer-Hoffert U et al. (2009) Molecular identification and expression analysis of filaggrin-2, a member of the S100 fused-type protein family. PLoS One 4:e5227
Yaqoob P, Shaikh SR (2010) The nutritional and clinical significance of lipid rafts. Curr Opin Clin Nutr Metab Care 13: 156-66
