Henrotin, Yves ; Université de Liège - ULiège > Département des sciences de la motricité > Unité de recherche sur l'os et le cartillage (U.R.O.C.)
Mathy, Marianne ; Université de Liège - ULiège > Département des sciences de la motricité > Unité de recherche sur l'os et le cartillage (U.R.O.C.)
Sanchez, Christelle ; Université de Liège - ULiège > Département des sciences de la motricité > Unité de recherche sur l'os et le cartillage (U.R.O.C.)
Lambert, Cécile ; Université de Liège - ULiège > Département des sciences de la motricité > Unité de recherche sur l'os et le cartillage (U.R.O.C.)
Language :
English
Title :
Chondroitin sulfate in the treatment of osteoarthritis: from in vitro studies to clinical recommendations
Publication date :
2010
Journal title :
Therapeutic Advances in Musculoskeletal Disease
ISSN :
1759-720X
eISSN :
1759-7218
Publisher :
SAGE Publications, New York, United States - New York
Albertini, R., Passi, A., Abuja, P.M. and de Luca, G. ( 2000) The effect of glycosaminoglycans and proteoglycans on lipid peroxidation. Int J Mol Med 6: 129-136.
Barnhill, J.G., Fye, C.L., Williams, D.W., Reda, D.J., Harris, C.L. and Clegg, D.O. ( 2006) Chondroitin product selection for the glucosamine/chondroitin arthritis intervention trial. J Am Pharm Assoc ( Wash DC) 46: 14-24.
Bassleer, C.T., Combal, J.P., Bougaret, S. and Malaise, M. ( 1998) Effects of chondroitin sulfate and interleukin-1 beta on human articular chondrocytes cultivated in clusters. Osteoarthritis Cartilage 6: 196-204.
Bian, L., Kaplun, M., Williams, D.Y., Xu, D., Ateshian, G.A. and Hung, C.T. (2009) Influence of chondroitin sulfate on the biochemical, mechanical and frictional properties of cartilage explants in long-term culture. J Biomechanics 42: 286-290.
Campo, G.M., Avenoso, A., Campo, S., D'Ascola, A., Ferlazzo, A.M. and Calatroni, A. ( 2004) Reduction of DNA fragmentation and hydroxyl radical production by hyaluronic acid and chondroitin-4-sulphate in iron plus ascorbate-induced oxidative stress in fibroblast cultures. Free Radic Res 38: 601-611.
Campo, G.M., Avenoso, A., Campo, S., D'Ascola, A., Traina, P. and Calatroni, A. ( 2008) Chondroitin-4-sulphate inhibits NF-kB translocation and caspase activation in collagen-induced arthritis in mice. Osteoarthritis Cartilage 16: 1474-1483.
Campo, G.M., Avenoso, A., Campo, S., D'Ascola, A., Traina, P., Sama, D. et al. (2009 a) Glycosaminoglycans modulate inflammation and apoptosis in LPS-treated chondrocytes. J Cell Biochem 106: 83-92.
Campo, G.M., Avenoso, A., Campo, S., Ferlazzo, A.M., Altavilla, D. and Calatroni, A. ( 2003) Efficacy of treatment with glycosaminoglycans on experimental collagen-induced arthritis in rats. Arthritis Res Ther 5: R122-R131.
Campo, G.M., Avenoso, A., Campo, S., Ferlazzo, A.M. and Calatroni, A. ( 2006a) Antioxidant activity of chondroitin sulfate. Adv Pharmacol 53: 417-431.
Campo, G.M., Avenoso, A., Campo, S., Ferlazzo, A.M. and Calatroni, A. ( 2006b) Chondroitin sulphate: antioxidant properties and beneficial effects. Mini Rev Med Chem 6: 1311-1320.
Campo, G.M., Avenoso, A., Campo, S., Traina, P., D'Ascola, A. and Calatroni, A. ( 2009b) Glycosaminoglycans reduced inflammatory response by modulating toll-like receptor-4 in LPS-stimulated chondrocytes. Arch Biochem Biophys 491: 7-15.
Caraglia, M., Beninati, S., Giuberti, G., D'Alessandro, A.M., Lentini, A., Abbruzzese, A. et al. (2005) Alternative therapy of earth elements increases the chondroprotective effects of chondroitin sulfate in mice. Exp Mol Med 37: 476-481.
Caterson, B., Mahmoodian, F., Sorrell, J.M., Hardingham, T.E., Bayliss, M.T., Carney, S.L. et al. (1990) Modulation of native chondroitin sulphate structure in tissue development and in disease. J Cell Sci 97: 411-417.
Chan, P.S., Caron, J.P. and Orth, M.W. ( 2005a) Effect of glucosamine and chondroitin sulfate on regulation of gene expression of proteolytic enzymes and their inhibitors in interleukin-1-challenged bovine articular cartilage explants. Am J Vet Res 66: 1870-1876.
Chan, P.S., Caron, J.P. and Orth, M.W. ( 2006) Short-term gene expression changes in cartilage explants stimulated with interleukin beta plus glucosamine and chondroitin sulfate. J Rheumatol 33: 1329-1340.
Chan, P.S., Caron, J.P. and Orth, M.W. ( 2007) Effects of glucosamine and chondroitin sulfate on bovine cartilage explants under long-term culture conditions. Am J Vet Res 68: 709-715.
Chan, P.S., Caron, J.P., Rosa, G.J. and Orth, M.W. ( 2005b) Glucosamine and chondroitin sulfate regulate gene expression and synthesis of nitric oxide and prostaglandin E (2) in articular cartilage explants. Osteoarthritis Cartilage 13: 387-394.
Cho, S.Y., Sim, J.S., Jeong, C.S., Chang, S.Y., Choi, D.W., Toida, T. et al. (2004) Effects of low molecular weight chondroitin sulfate on type II collagen-induced arthritis in DBA/1J mice. Biol Pharm Bull 27: 47-51.
Chou, M.M., Vergnolle, N., McDougall, J.J., Wallace, J.L., Marty, S., Teskey, V. et al. (2005) Effects of chondroitin and glucosamine sulfate in a dietary bar formulation on inflammation, interleukin-1beta, matrix metalloprotease-9, and cartilage damage in arthritis. Exp Biol Med 230: 255-262.
Clegg, D.O., Reda, D.J., Harris, C.L. and Klein, M.A. ( 2005) The efficacy of glucosamine and chondroitin sulfate in patients with painful knee osteoarthritis (OA): The glucosamine/chondroitin arthritis intervention trial. Arthritis Rheum 52(9S): S256, (Abstract).
Clegg, D.O., Reda, D.J., Harris, C.L., Klein, M.A., O'Dell, J.R., Hooper, M.M. et al. (2006) Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. N Engl J Med 354: 795-808.
Conte, A., Volpi, N., Palmieri, L., Bahous, I. and Ronca, G. ( 1995) Biochemical and pharmacokinetic aspects of oral treatment with chondroitin sulfate. Arzneimittelforschung 45: 918-925.
David-Raoudi, M., Deschrevel, B., Leclercq, S., Galera, P., Boumediene, K. and Pujol, J.P. (2009) Chondroitin sulfate increases hyaluronan production by human synoviocytes through differential regulation of hyaluronan synthases: Role of p 38 and Akt. Arthritis Rheum 60: 760-770.
du Souich, P., Garcia, A.G., Verges, J. and Montell, E. ( 2009) Immunomodulatory and anti-inflammatory effects of chondroitin sulphate. J Cell Mol Med 13(8A): 1451-1463.
du Souich, P. and Vergès, J. ( 2001) Simple approach to predict the maximal effect elicited by a drug when plasma concentrations are not available or are dissociated from the effect, as illustrated with chondroitin sulfate data. Clin Pharmacol Ther 70: 5-9.
Egea, J., Garcia, A.G., Verges, J., Montell, E. and Lopez, M.G. (2010) Antioxidant, antiinflammatory and neuroprotective actions of chondroitin sulfate and proteoglycans. Osteoarthritis Cartilage 18(Suppl. 1): S24-S28.
Hochberg, M.C. ( 2010) Structure-modifying effects of chondroitin sulfate in knee osteoarthritis: an updated meta-analysis of randomized placebo-controlled trials of 2-year duration. Osteoarthritis Cartilage 18(Suppl. 1): 528-531.
Hochberg, M.C. and Clegg, D.O. ( 2008) Potential effects of chondroitin sulfate on joint swelling: a GAIT report. Osteoarthritis Cartilage 16(Suppl. 3): S22-S24.
Hochberg, M.C., Zhan, M. and Langenberg, P. ( 2008) The rate of decline of joint space width in patients with osteoarthritis of the knee: a systematic review and meta-analysis of randomized placebo-controlled trials of chondroitin sulfate. Curr Med Res Opin, in press.
Holzmann, J., Brandl, N., Zemann, A., Schabus, R., Marlovits, S., Cowburn, R. et al. (2006) Assorted effects of TGFbeta and chondroitinsulfate on p 38 and ERK1/2 activation levels in human articular chondrocytes stimulated with LPS. Osteoarthritis Cartilage 14: 519-525.
Imada, K., Oka, H., Kawasaki, D., Miura, N., Sato, T. and Ito, A. (2010) Anti-arthritic action mechanisms of natural chondroitin sulfate in human articular chondrocytes and synovial fibroblasts. Biol Pharm Bull 33: 410-414.
Jackson, C.G., Plaas, A.H., Sandy, J.D., Hua, C., Kim-Rolands, S., Barnhill, J.G. et al. (2010) The human pharmacokinetics of oral ingestion of glucosamine and chondroitin sulfate taken separately or in combination. Osteoarthritis Cartilage 18: 297-302.
Jomphe, C., Gabriac, M., Hale, T.M., Heroux, L., Trudeau, L.E., Deblois, D. et al. (2008) Chondroitin sulfate inhibits the nuclear translocation of nuclear factor-kappaB in interleukin-1beta-stimulated chondrocytes. Basic Clin Pharmacol Toxicol 102: 59-65.
Jordan, K.M., Arden, N.K., Doherty, M., Bannwarth, B., Bijlsma, J.W., Dieppe, P. et al. (2003) EULAR Recommendations 2003: an evidence based approach to the management of knee osteoarthritis: Report of a Task Force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT). Ann Rheum Dis 62: 1145-1155.
Kahan, A., Uebelhart, D., de Vathaire, F., Delmas, P.D. and Reginster, J.Y. (2009) Long-term effects of chondroitins 4 and 6 sulfate on knee osteoarthritis: The study on osteoarthritis progression prevention, a two-year, randomized, double-blind, placebo-controlled trial. Arthritis Rheum 60: 524-533.
Katta, J., Jin, Z., Ingham, E. and Fisher, J. (2009) Chondroitin sulphate: an effective joint lubricant? Osteoarthritis Cartilage 17: 1001-1008.
Kusano, S., Ootani, A., Sakai, S., Igarashi, N., Takeguchi, A., Toyoda, H. et al. (2007) HPLC determination of chondrosine in mouse blood plasma after intravenous or oral dose. Biol Pharm Bull 30: 1365-1368.
Lauder, R.M. (2009) Chondroitin sulphate: A complex molecule with potential impacts on a wide range of biological systems. Complement Therapies Med 17: 56-62.
Lauder, R.M., Huckerby, T.N. and Nieduszynski, I.A. ( 2000) A fingerprinting method for chondroitin/dermatan sulfate and hyaluronan oligosaccharides. Glycobiology 10: 393-401.
Lee, Y.H., Woo, J.H., Choi, S.J., Ji, J.D. and Song, G. G (2010) Effect of glucosamine or chondroitin sulfate on the osteoarthritis progression: a meta-analysis. Rheumatol Int 30: 357-363.
Leeb, B.F., Schweitzer, H., Montag, K. and Smolen, J.S. ( 2000) A metaanalysis of chondroitin sulfate in the treatment of osteoarthritis. J Rheumatol 27: 205-211.
Legendre, F., Bauge, C., Roche, R., Saurel, A.S. and Pujol, J.P. ( 2008) Chondroitin sulfate modulation of matrix and inflammatory gene expression in IL-1beta-stimulated chondrocytes-study in hypoxic alginate bead cultures. Osteoarthritis Cartilage 16: 105-114.
Malavaki, C.J., Asimakopoulou, A.P., Lamari, F.N., Theocharis, A.D., Tzanakakis, G.N. and Karamanos, N.K. ( 2008) Capillary electrophoresis for the quality control of chondroitin sulfates in raw materials and formulations. Anal Biochem 374: 213-220.
Maziéres, B., Hucher, M., Zaim, M. and Garnero, P. ( 2007) Effect of chondroitin sulphate in symptomatic knee osteoarthritis: a multicentre, randomised, double-blind, placebo-controlled study. Ann Rheum Dis 66: 639-645.
Maziéres, B., Hucher, M.M.H. and Zam, M.M.Z. ( 2006) Chondroitin sulfate in the treatment for knee osteoarthritis: a randomized, double blind, multicenter, placebo-controlled trial. Ann Rheum Dis 65(Suppl. II): 398.
McAlindon, T.E., LaValley, M.P., Gulin, J.P. and Felson, D.T. ( 2000) Glucosamine and chondroitin for treatment of osteoarthritis: a systematic quality assessment and meta-analysis. JAMA 283: 1469-1475.
Möller, I., Pérez, M., Monfort, J., Benito, P., Cuevas, J., Perna, C. et al. (2010) Effectiveness of chondroitin sulphate in patients with concomitant knee osteoarthritis and psoriasis: a randomized, double-blind, placebo-controlled study. Osteoarthritis Cartilage 18(Suppl. 1): 532-540.
Monfort, J., Martel-Pelletier, J. and Pelletier, J.P. ( 2008a) Chondroitin sulphate for symptomatic osteoarthritis: critical appraisal of meta-analyses. Curr Med Res Opin 24: 1303-1308.
Monfort, J., Nacher, M., Montell, E., Vila, J., Verges, J. and Benito, P. ( 2005) Chondroitin sulfate and hyaluronic acid (500-730 kDa) inhibit stromelysin-1 synthesis in human osteoarthritic chondrocytes. Drugs Exp Clin Res 31: 71-76.
Monfort, J., Pelletier, J.P., Garcia-Giralt, N. and Martel-Pelletier, J. ( 2008b) Biochemical basis of the effect of chondroitin sulphate on osteoarthritis articular tissues. Ann Rheum Dis 67: 735-740.
Mourao, P.A. ( 1988) Distribution of chondroitin 4-sulfate and chondroitin 6-sulfate in human articular and growth cartilage. Arthritis Rheum 31: 1028-1033.
Omata, T., Itokazu, Y., Inoue, N. and Segawa, Y. ( 2000) Effects of chondroitin sulfate-C on articular cartilage destruction in murine collagen-induced arthritis. Arzneimittelforschung 50: 148-153.
Rainsford, K.D. ( 2009) Importance of pharmaceutical composition and evidence from clinical trials and pharmacological studies in determining effectiveness of chondroitin sulphate and other glycosaminoglycans: a critique. J Pharm Pharmacol 61: 1263-1270.
Reichenbach, S., Sterchi, R., Scherer, M., Trelle, S., Burgi, E., Burgi, U. et al. (2007) Meta-analysis: chondroitin for osteoarthritis of the knee or hip. Ann Intern Med 146: 580-590.
Richy, F., Bruyere, O., Ethgen, O., Cucherat, M., Henrotin, Y. and Reginster, J.Y. ( 2003) Structural and symptomatic efficacy of glucosamine and chondroitin in knee osteoarthritis: a comprehensive meta-analysis. Arch Intern Med 163: 1514-1522.
Ronca, F., Palmieri, L., Panicucci, P. and Ronca, G. ( 1998) Anti-inflammatory activity of chondroitin sulfate. Osteoarthritis Cartilage 6(Suppl. A): 14-21.
Sawitzke, A.D., Shi, H., Finco, M.F., Dunlop, D.D., Bingham, C.O., Harris, C.L. et al. (2008) The effect of glucosamine and/or chondroitin sulfate on the progression of knee osteoarthritis: a report from the glucosamine/chondroitin arthritis intervention trial. Arthritis Rheum 58: 3183-3191.
Schwartz, N.B. and Dorfman, A. ( 1975) Stimulation of chondroitin sulfate proteoglycan production by chondrocytes in monolayer. Connect Tissue Res 3: 115-122.
Shinmei, M., Miyauchi, S., Machida, A. and Miyazaki, K. ( 1992) Quantitation of chondroitin 4-sulfate and chondroitin 6-sulfate in pathologic joint fluid. Arthritis Rheum 35: 1304-1308.
Tahiri, K., Korwin-Zmijowska, C., Richette, P., Heraud, F., Chevalier, X., Savouret, J.F. et al. (2008) Natural chondroitin sulphates increase aggregation of proteoglycan complexes and decrease ADAMTS-5 expression in interleukin 1 beta-treated chondrocytes. Ann Rheum Dis 67: 696-702.
Tat, S.K., Pelletier, J.P., Mineau, F., Duval, N. and Martel-Pelletier, J. (2010) Variable effects of 3 different chondroitin sulfate compounds on human osteoarthritic cartilage/chondrocytes: relevance of purity and production process. J Rheumatol 37: 656-664.
Tat, S.K., Pelletier, J.P., Vergés, J., Montell, E., Lajeunesse, D., Fahmi, H. et al. (2007) Chondroitin and glucosamine sulfate in combination decrease the pro-resorptive properties of human osteoarthritis subchondral bone osteoblasts. Arthritis Res Ther 9: R117.
Uebelhart, D., Thonar, E.J., Zhang, J. and Williams, J.M. ( 1998) Protective effect of exogenous chondroitin 4,6-sulfate in the acute degradation of articular cartilage in the rabbit. Osteoarthritis Cartilage 6(Suppl. A): 6-13.
Vallières, M. and du Souich, P. ( 2010) Modulation of inflammation by chondroitin sulfate. Osteoarthritis Cartilage 18(Suppl. 1): S1-S6.
Vangsness Jr, C.T., Spiker, W. and Erickson, J. ( 2009) A Review of Evidence-Based Medicine for Glucosamine and Chondroitin Sulfate Use in Knee Osteoarthritis. Arthroscopy: J Arthroscopic Relat Surg 25: 86-94.
Verbruggen, G. and Veys, E.M. ( 1977) Influence of sulphated glycosaminoglycans upon proteoglycan metabolism of the synovial lining cells. Acta Rhumatol Belg 1: 75-92.
Verges, J., Montell, E., Herrero, M., Perna, C., Cuevas, J., Perez, M. et al. (2005) Clinical and histopathological improvement of psoriasis with oral chondroitin sulfate: a serendipitous finding. Dermatol Online J 11: 31.
Vergés, J., Montell, E., Martinez, G., Heroux, L. and du Souich, P. ( 2004) Chondroitin sulfate reduces nuclear translocation factor NF-kappaB and does not modify the activation state of activating protein-1 (AP-1). Osteoarthritis Cartilage 12: 194, (Abstract).
Volpi, N. ( 2002) Oral bioavailability of chondroitin sulfate (Condrosulf) and its constituents in healthy male volunteers. Osteoarthritis Cartilage 10: 768-777.
Volpi, N. ( 2003) Oral absorption and bioavailability of ichthyic origin chondroitin sulfate in healthy male volunteers. Osteoarthritis Cartilage 11: 433-441.
Volpi, N. ( 2006a) Advances in chondroitin sulfate analysis: application in physiological and pathological States of connective tissue and during pharmacological treatment of osteoarthritis. Curr Pharm Des 12: 639-658.
Volpi, N. ( 2006b) Chondroitin Sulfate: Structure, Role and Pharmacological Activity, Elsevier: Amsterdam.
Volpi, N. ( 2009) Quality of different chondroitin sulfate preparations in relation to their therapeutic activity. J Pharm Pharmacol 61: 1271-1280.
Volpi, N. and Tarugi, P. ( 1999) Influence of chondroitin sulfate charge density, sulfate group position, and molecular mass on Cu2+-mediated oxidation of human low-density lipoproteins: effect of normal human plasma-derived chondroitin sulfate. J Biochem 125: 297-304.
Wang, L., Wang, J., Almqvist, K.F., Veys, E.M. and Verbruggen, G. ( 2002) Influence of polysulphated polysaccharides and hydrocortisone on the extracellular matrix metabolism of human articular chondrocytes in vitro. Clin Exp Rheumatol 20: 669-676.
Zhang, W., Doherty, M., Arden, N., Bannwarth, B., Bijlsma, J., Gunther, K.P. et al. (2005) EULAR evidence based recommendations for the management of hip osteoarthritis: report of a task force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT). Ann Rheum Dis 64: 669-681.
Zhang, W., Moskowitz, R.W., Nuki, G., Abramson, S., Altman, R.D., Arden, N. et al. (2008) OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines. Osteoarthritis Cartilage 16: 137-162.
Zhang, W., Nuki, G., Moskowitz, R.W., Abramson, S., Altman, R.D., Arden, N.K. et al. (2010) OARSI recommendations for the management of hip and knee osteoarthritis Part III: changes in evidence following systematic cumulative update of research published through January 2009. Osteoarthritis Cartilage 18 (4): 476-499.