[fr] M. haemolytica sérotype A1 (anciennement dénommée Pasteurella) est l’agent pathogène le plus fréquemment isolé lors de cas mortels de bronchopneumonie infectieuse bovine. M. haemolytica et ses deux principales toxines, le lipopolysaccharide (LPS) et la leucotoxine (LktA), induisent le recrutement, l’activation et la nécrose des neutrophiles fortement impliqués dans la pathogénie des broncho-pneumonies bovines à Mannheimia (BPM). Le but de notre étude fut de déterminer l’effet d’une administration thérapeutique de carprofène (Rimadyl® bovins*), un anti-inflammatoire non steroïdien (AINS), sur l’évolution des paramètres cliniques et nécropsiques dans un modèle de BPM aiguë expérimentalement induite chez des veaux. Les
veaux ont été inoculés par M. haemolytica et ses toxines à T0, et traités (n=6) ou non (n=6) au caprofène (1,4 mg/kg IV) à T+1. Les paramètres cliniques et biochimiques ont été évalués une (T+1), trois (T+3) et sept (T+7) heures après inoculation. A T+1, l’établissement de la pathologie a été confirmée de manière significative par l’aggravation du score clinique et l’augmentation de la fréquence respiratoire chez l’ensemble des veaux. L’administration de carprofène a empêché une diminution de la saturation du sang en oxygène à T+3, une dégradation du score clinique et une augmentation de la lactatémie à T+7. Pour ces trois paramètres, les différences observées étaient significatives. Al’autopsie, l’étendue des lésions pulmonaires était diminuée de manière significative dans le groupe traité au carprofène. Ces résultats montrent que l’injection de carprofène après l’apparition des premiers signes cliniques de BPM permet d’améliorer l’état clinique des veaux et de réduire l’étendue des lésions pulmonaires. [en] M. haemolytica serotype A1 (formerly known as Pasteurella) is the most important and commonly isolated bacterial pathogen from fatal cases of bovine fibrinous pleuroneumonia. M. haemolytica and its two principal toxins, the lipopolysaccharides (LPS) and the leukotoxin (LktA) induce the recruitment, the activation and the necrosis of neutrophils involved in the pathogenicity of bovine pneumonic mannheimiosis (BPM). The objective of this study was to determine whether systemic therapy with carprofène (Rimadyl®*), a non-steroidal anti-inflammatory drug, improves the disease development in an acute experimental model of BPM. The experimental pathology was induced by trans-tracheal inoculation of M. haemolytica and toxins at T0. One hour post-inoculation, six calves were treated intravenously with carprofen (1,4 mg/kg) while six placebo-treated calves received dose-matched volumes of sterile saline. The clinical and biochemical parameters were measured at one (T+1), three (T+3) and seven (T+7) hours after inoculation. Disease scores for carprofen treated calves were significantly lower than those for placebo-treated controls six hours (T+7) after treatment. These results were associated to a significantly oxygen saturation decrease at T+3 and a significantly blood lactate increase at T+7 in the control calves. Moreover, pulmonary lesions were significantly less extensive than those in the control group. Taken together, this finding suggest that pharmacological modulation by carprofen of pulmonary inflammation after appearance of acute BPM clinical signs leads to calves’ health enhancement and reduces the extent of gross pneumonic lesion.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Wallemacq, Hugues; Université de Liège - ULiège
Boutet, Philippe; Université de Liège - ULiège
Zecchinon, L.; université de liège
Desmecht, Daniel ; Université de Liège - ULiège > Département de morphologie et pathologie > Pathologie spéciale et autopsies
Bedoret, Denis; Université de Liège - ULiège
Ramery, Eve ; Université de Liège - ULiège > Département de sciences fonctionnelles > Biochimie
Lekeux, Pierre ; Université de Liège - ULiège > Département de sciences fonctionnelles > Physiologie
Language :
French
Title :
Evaluation de l’efficacité du Caprofène lors de bronchoneumonie expérimentale bovine à Mannheimia haemolytica
Alternative titles :
[en] Clinical effects of Carprofen during experimental bovine pneumonic mannheimiosis
Publication date :
2007
Journal title :
Revue de Médecine Vétérinaire
ISSN :
0035-1555
eISSN :
2258-0646
Publisher :
Ecole Nationale Vétérinaire Toulouse, Toulouse, France
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