Reference : Reduced intensity conditioning for allogeneic hematopoietic stem cell transplantation...
Scientific journals : Article
Human health sciences : Hematology
Reduced intensity conditioning for allogeneic hematopoietic stem cell transplantation (HSCT)
Servais, Sophie [Université de Liège - ULiège > > Frais communs médecine >]
Beguin, Yves mailto [Université de Liège - ULiège > > GIGA-R : Hématologie >]
Baron, Frédéric [Université de Liège - ULiège > > GIGA-R : Hématologie - Département des sciences cliniques >]
Belgian Journal of Hematology
Ariez Medical Publishing
The Netherlands
[en] reduced-intensity conditioning ; hematopoietic stem cell transplantation ; graft-versus-tumor effects ; graft-versus-host disease
[en] Reduced intensity conditioning (RIC) regimens have allowed performing allogeneic haematopoietic stem cell transplantation (HSCT) in patients for whom conventional myeloablative allogeneic HSCT is associated with unacceptable risks of non-relapse-mortality. This approac relies mainly on graft-versus-tumour effects for tumour eradication. Retrospective studies have suggested that, in patients aged 40 to 60 years, RIC-HSCT was associated with a higher risk of relapse but a lower incidence of transplant-related mortality than myeloablative allogeneic HSCT, leading to similar progression-free and overall survivals. After reviewing the rationale for RIC-HSCT, this article discusses the results of RIC-HSCT in specific deseases, and proposes what could be current indications for RIC-HSCT in 2011. Finally, the article briefly presents some possible strategies aimed at increasing the anti-tumoral activity of the procedure while reducing the incidence and severity of acute graft-versus-host disease.

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