Reference : Cloning of a mitogen-inducible gene encoding a kappa B DNA-binding protein with homol...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
Cloning of a mitogen-inducible gene encoding a kappa B DNA-binding protein with homology to the rel oncogene and to cell-cycle motifs.
Bours, Vincent mailto [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > GIGA-R : Génétique humaine >]
Villalobos, J. [> > > >]
Burd, P. R. [> > > >]
Kelly, K. [> > > >]
Siebenlist, U. [> > > >]
Nature Publishing Group
Yes (verified by ORBi)
United Kingdom
[en] Amino Acid Sequence ; Base Sequence ; Binding Sites ; Cell Cycle ; DNA/genetics ; DNA-Binding Proteins/genetics ; Humans ; Mitogens/pharmacology ; Molecular Sequence Data ; NF-kappa B/genetics ; Phytohemagglutinins/pharmacology ; Proto-Oncogene Proteins/genetics ; Proto-Oncogene Proteins c-rel ; RNA, Messenger/biosynthesis ; Repetitive Sequences, Nucleic Acid ; Sequence Homology, Nucleic Acid ; T-Lymphocytes/chemistry ; Tetradecanoylphorbol Acetate/pharmacology
[en] We have cloned and characterized a mitogen-inducible gene isolated from human T cells that predicts a protein of 968 amino acids. The amino-terminal domain has regions homologous to the oncogene rel and to the developmentally important gene dorsal of Drosophila. The carboxy-terminal domain contains repeat structures found in a variety of proteins that are involved in cell-cycle control of yeast and in tissue differentiation in Drosophila and Ceanorhabditis elegans, as well as in the putative human oncogene bcl-3 and in the ankyrin protein. A truncated form of the product of this gene translated in vitro is a DNA-binding protein which interacts specifically with the kappa B binding site found in many inducible genes, including the enhancer in human immunodeficiency virus. This gene is yet another in a growing list of important regulatory molecules whose expression is transcriptionally induced upon cellular activation.

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