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Article (Scientific journals)
Cloning of a mitogen-inducible gene encoding a kappa B DNA-binding protein with homology to the rel oncogene and to cell-cycle motifs.
Bours, Vincent; Villalobos, J.; Burd, P. R. et al.
1990In Nature, 348 (6296), p. 76-80
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Keywords :
Amino Acid Sequence; Base Sequence; Binding Sites; Cell Cycle; DNA/genetics; DNA-Binding Proteins/genetics; Humans; Mitogens/pharmacology; Molecular Sequence Data; NF-kappa B/genetics; Phytohemagglutinins/pharmacology; Proto-Oncogene Proteins/genetics; Proto-Oncogene Proteins c-rel; RNA, Messenger/biosynthesis; Repetitive Sequences, Nucleic Acid; Sequence Homology, Nucleic Acid; T-Lymphocytes/chemistry; Tetradecanoylphorbol Acetate/pharmacology
Abstract :
[en] We have cloned and characterized a mitogen-inducible gene isolated from human T cells that predicts a protein of 968 amino acids. The amino-terminal domain has regions homologous to the oncogene rel and to the developmentally important gene dorsal of Drosophila. The carboxy-terminal domain contains repeat structures found in a variety of proteins that are involved in cell-cycle control of yeast and in tissue differentiation in Drosophila and Ceanorhabditis elegans, as well as in the putative human oncogene bcl-3 and in the ankyrin protein. A truncated form of the product of this gene translated in vitro is a DNA-binding protein which interacts specifically with the kappa B binding site found in many inducible genes, including the enhancer in human immunodeficiency virus. This gene is yet another in a growing list of important regulatory molecules whose expression is transcriptionally induced upon cellular activation.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Bours, Vincent ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > GIGA-R : Génétique humaine
Villalobos, J.
Burd, P. R.
Kelly, K.
Siebenlist, U.
Language :
English
Title :
Cloning of a mitogen-inducible gene encoding a kappa B DNA-binding protein with homology to the rel oncogene and to cell-cycle motifs.
Publication date :
1990
Journal title :
Nature
ISSN :
0028-0836
eISSN :
1476-4687
Publisher :
Nature Publishing Group, Basingstoke, United Kingdom
Volume :
348
Issue :
6296
Pages :
76-80
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 23 November 2010

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