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Keywords :
3T3 Cells; Amino Acid Sequence; Animals; Base Sequence; DNA-Binding Proteins; Fungal Proteins/genetics/metabolism; Gene Expression Regulation/physiology; Mice; Molecular Sequence Data; Multigene Family/genetics; NF-kappa B/metabolism; Oncogene Proteins v-rel; Oncogenes/genetics; Precipitin Tests; Recombinant Fusion Proteins/genetics/metabolism; Retroviridae Proteins, Oncogenic/chemistry/genetics/metabolism; Saccharomyces cerevisiae/genetics; Saccharomyces cerevisiae Proteins; Transcription Factors/metabolism; beta-Galactosidase/genetics/metabolism
Abstract :
[en] We have identified a serum-inducible gene, relB, which encodes a protein of 558 amino acids containing a region with high similarity to c-Rel and other members of the Rel family. Transcriptional activation analysis of GAL4-RelB fusion proteins in yeast cells reveals that RelB contains in its C-terminal 180 amino acids a transcriptional activation domain. The N-terminal part including the region of similarity with the Rel family shows no detectable transcriptional activity. RelB does not bind with high affinity to NF-kappa B sites, but heterodimers between RelB and p50-NF-kappa B do bind to different NF-kappa B-binding sites with a similar affinity to that shown by p50-NF-kappa B homodimers. However, RelB/p50-NF-kappa B heterodimers, in contrast to p50-NF-kappa B homodimers, transactivate transcription of a promoter containing a kappa B-binding site.
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