Reference : RelB, a new Rel family transcription activator that can interact with p50-NF-kappa B.
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
RelB, a new Rel family transcription activator that can interact with p50-NF-kappa B.
Ryseck, R. P. [> > > >]
Bull, P. [> > > >]
Takamiya, M. [> > > >]
Bours, Vincent mailto [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > GIGA-R : Génétique humaine >]
Siebenlist, U. [> > > >]
Dobrzanski, P. [> > > >]
Bravo, R. [> > > >]
Molecular and Cellular Biology
American Society for Microbiology (ASM)
Yes (verified by ORBi)
[en] 3T3 Cells ; Amino Acid Sequence ; Animals ; Base Sequence ; DNA-Binding Proteins ; Fungal Proteins/genetics/metabolism ; Gene Expression Regulation/physiology ; Mice ; Molecular Sequence Data ; Multigene Family/genetics ; NF-kappa B/metabolism ; Oncogene Proteins v-rel ; Oncogenes/genetics ; Precipitin Tests ; Recombinant Fusion Proteins/genetics/metabolism ; Retroviridae Proteins, Oncogenic/chemistry/genetics/metabolism ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae Proteins ; Transcription Factors/metabolism ; beta-Galactosidase/genetics/metabolism
[en] We have identified a serum-inducible gene, relB, which encodes a protein of 558 amino acids containing a region with high similarity to c-Rel and other members of the Rel family. Transcriptional activation analysis of GAL4-RelB fusion proteins in yeast cells reveals that RelB contains in its C-terminal 180 amino acids a transcriptional activation domain. The N-terminal part including the region of similarity with the Rel family shows no detectable transcriptional activity. RelB does not bind with high affinity to NF-kappa B sites, but heterodimers between RelB and p50-NF-kappa B do bind to different NF-kappa B-binding sites with a similar affinity to that shown by p50-NF-kappa B homodimers. However, RelB/p50-NF-kappa B heterodimers, in contrast to p50-NF-kappa B homodimers, transactivate transcription of a promoter containing a kappa B-binding site.

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