[en] In a cross-sectional population study to assess whether environmental exposure to cadmium associated with renal dysfunction, 1699 subjects aged 20-80 years were studied as a random sample of four areas of Belgium with varying degrees of cadmium pollution. After standardisation fo several possible confounding factors, five variables (urinary excretion of retinol-binding protein, N-acetyl-ß-glucosaminidase, ß2-microglobulin, aminoacids, and calcium) were significantly associated with the urinary excretion of cadmium (as a marker of cadmium body burden) suggesting the presence of tubular dysfunction. There was a 10% probablility of values of these variables being abnormal when cadmium excretion exceeded 2-4 µg/24h. Excretion reached also evidence that diabetic patients may be more susceptible to the toxic effect of cadmium on the renal proximal tubule.
Disciplines :
Urology & nephrology Public health, health care sciences & services
Author, co-author :
Buchet, J. P.; Université Catholique de Louvain - UCL > Industrial Toxicology and Occupational Medicine Unit
Lauwerys, R.; Université Catholique de Louvain - UCL > Industrial Toxicology and Occupational Medicine Unit
Roels, H.; Université Catholique de Louvain - UCL > Industrial Toxicology and Occupational Medicine Unit
Bernard, A.; Université Catholique de Louvain - UCL > Industrial Toxicology and Occupational Medicine Unit
Bruaux, P.; Ministry of Health and Social Affairs, Brusels, Belgium > Institute of Hygiene and Epidemiology
Claeys, F.; Ministry of Health and Social Affairs, Brusels, Belgium > Institute of Hygiene and Epidemiology
Ducoffre, G.; Ministry of Health and Social Affairs, Brusels, Belgium > Institute of Hygiene and Epidemiology
De Plaen, P.; Ministry of Health and Social Affairs, Brusels, Belgium > Institute of Hygiene and Epidemiology
Staessen; Katholieke Universiteit Leuven - KUL > Pathophysiology > Hypertension nd Cardiovascular Rehabilitation Unit
Amery, A.; Katholieke Universiteit Leuven - KUL > Pathophysiology > Hypertension and Cardiovascular Rehabilitation Unit
Lijnen, P.; Katholieke Universiteit Leuven - KUL > Pathophysiology > Hypertension and Cardiovascular Rehabilitation Unit
Thijs, L.; Katholieke Universiteit Leuven - KUL > Pathophysiology > Hypertension and Cardiovascular Rehabilitation Unit
Rondia, D.; Université de Liège - ULiège > Environmental Toxicology Unit
Sartor, F.; Université de Liège - ULiège > Environmental Toxicology Unit
Saint-Remy, Annie ; Université de Liège - ULiège > Département des sciences cliniques > Néphrologie
Nick, L.; Université de Liège - ULiège > Environmental Toxicology Unit
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