Boyar R, Finkelstein J, Roffwarg H, Kapen S, Weitzman E, Hellman L 1972 Synchronization of augmented luteinizing hormone secretion with sleep during puberty. N Engl J Med 287:582-586
Ojeda SR, Terasawa E 2002 Neuroendocrine regulation of puberty. In: Pfaff D, Arnold A, Etgen A, Fahrbach S, Moss R, Rubin R, eds. Hormones, brain and behavior. Vol 4. New York: Elsevier; 589-659
Plant TM 2002 Neurophysiology of puberty. J Adolesc Health 31:185-191
Ojeda SR, Skinner MK 2005 Puberty in the rat. In: Neill JD, ed. The physiology of reproduction. 3rd ed. San Diego: Academic Press/Elsevier; 2061-2126
de Roux N, Genin E, Carel J-C, Matsuda F, Chaussain J-L, Milgrom E 2003 Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54. Proc Natl Acad Sci USA 100:10972-10976
Seminara SB, Messager S, Chatzidaki EE, Thresher RR, Acierno Jr JS, Shagoury JK, Bo-Abbas Y, Kuohung W, Schwinof KM, Hendrick AG, Zahn D, Dixon J, Kaiser UB, Slaugenhaupt SA, Gusella JF, O'Rahilly S, Carlton MB, Crowley Jr WF, Aparicio SA, Colledge WH 2003 The GPR54 gene as a regulator of puberty. N Engl J Med 349:1614-1627
Terasawa E, Fernandez DL 2001 Neurobiological mechanisms of the onset of puberty in primates. Endocr Rev 22:111-151
Terasawa E 1999 Hypothalamic control of the onset of puberty. Curr Opin Endocrinol Diabetes 6:44-49
Ojeda SR, Ma YJ, Dziedzic B, Prevot V 2000 Astrocyte-neuron signaling and the onset of female puberty. In: Bourguignon J-P, Plant TM, eds. The onset of puberty in perspective. Amsterdam: Elsevier Science B.V.; 41-57
Ojeda SR, Prevot V, Heger S, Lomniczi A, Dziedzic B, Mungenast A 2003 Glia-to neuron signaling and the neuroendocrine control of female puberty. Ann Med 35:244-255
Klipp E, Herwig R, Kowald A, Wierling C, Lehrach H 2005 Systems biology in practice. Weinheim, Germany: Wiley-VCH; 3-449
Ideker T, Thorsson V, Ranish JA, Christmas R, Buhler J, Eng JK, Bumgarner R, Goodlett DR, Aebersold R, Hood L 2001 Integrated genomic and proteomic analyses of a systematically perturbed metabolic network. Science 292:929-934
Bourguignon J-P, Lebrethon MC, Gérard A, Purnell G, Vandersmissen E, Parent AS, Yamanaka C 2000 Amino acid neurotransmission and early ontogeny of pulsatile GnRH secretion from the rat hypothalamus. In: Bourguignon J-P, Plant TM, eds. The onset of puberty in perspective. Amsterdam: Elsevier Science B.V.; 119-129
van den Pol AN, Trombley PQ 1993 Glutamate neurons in hypothalamus regulate excitatory transmission. J Neurosci 13:2829-2836
Claypool LE, Kasuya E, Saitoh Y, Marzban F, Terasawa E 2000 N-methyl D,L-aspartate induces the release of luteinizing hormone-releasing hormone in the prepubertal and pubertal female rhesus monkey as measured by in vivo push-pull perfusion in the stalk-median eminence. Endocrinology 141:219-228
Donoso AO, López FJ, Negro-Vilar A 1990 Glutamate receptors of the non-N-methyl-D-aspartic acid type mediate the increase in luteinizing hormone releasing hormone release by excitatory amino acid in vitro. Endocrinology 126:414-420
Plant TM, Gay VL, Marshall GR, Arslan M 1989 Puberty in monkeys is triggered by chemical stimulation of the hypothalamus. Proc Natl Acad Sci USA 86:2506-2510
Urbanski HF, Ojeda SR 1990 A role for N-methyl-D-aspartate (NMDA) receptors in the control of LH secretion and initiation of female puberty. Endocrinology 126:1774-1776
Ottem EN, Godwin JG, Petersen SL 2002 Glutamatergic signaling through the N-methyl-D-aspartate receptor directly activates medial subpopulations of luteinizing hormone-releasing hormone (LHRH) neurons, but does not appear to mediate the effects of estradiol on LHRH gene expression. Endocrinology 143:4837-4845
Gore AC 2001 Gonadotropin-releasing hormone neurons. NMDA receptors, and their regulation by steroid hormones across the reproductive life cycle. Brain Res Rev 37:235-248
Eyigor O, Jennes L 1997 Expression of glutamate receptor subunit mRNAs in gonadotropin-releasing hormone neurons during the sexual maturation of the female rat. Neuroendocrinology 66:122-129
Eyigor O, Jennes L 2000 Kainate receptor subunit-positive gonadotropin-releasing hormone neurons express c-Fos during the steroid-induced luteinizing hormone surge in the female rat. Endocrinology 141:779-786
van den Pol AN, Wuarin J-P, Dudek FE 1990 Glutamate, the dominant excitatory transmitter in neuroendocrine regulation. Science 250:1276-1278
Brann DW, Zamorano PL, Ping L, Mahesh VB 1993 Role of excitatory amino acid neurotransmission during puberty in the female rat. Mol Cell Neurosci 4:107-112
Gygi SP, Rist B, Gerber SA, Turecek F, Gelb MH, Aebersold R 1999 Quantitative analysis of complex protein mixtures using isotope-coded affinity tags. Nat Biotechnol 17:994-999
Roth CL, McCormack AL, Lomniczi A, Mungenast AE, Ojeda SR, Quantitative proteomics identifies a major change in glial glutamate metabolism at the time of female puberty. Mol Cell Endocrinol, in press
Erecinska M, Silver IA 1990 Metabolism and role of glutamate in mammalian brain. Prog Neurobiol 35:245-296
Takamori S, Rhee JS, Rosenmund C, John R 2000 Identification of a vesicular glutamate transporter that defines a glutamatergic phenotype in neurons. Nature 407:189-194
Fremeau Jr RT, Troyer MD, Pahner I, Nygaard GO, Tran CH, Reimer RJ, Bellocchio EE, Fortin D, Storm-Mathisen J, Edwards RH 2001 The expression of vesicular glutamate transporters defines two classes of excitatory synapse. Neuron 31:247-260
De Gois S, Schafer MK, Defamie N, Chen C, Ricci A, Weihe E, Varoqui H, Erickson JD 2005 Homeostatic scaling of vesicular glutamate and GABA transporter expression in rat neocortical circuits. J Neurosci 25:7121-7133
Muir AI, Chamberlain L, Elshourbagy NA, Michalovich D, Moore DJ, Calamari A, Szekeres PG, Sarau HM, Chambers JK, Murdock P, Steplewski K, Shabon U, Miller JE, Middleton SE, Darker JG, Larminie CG, Wilson S, Bergsma DJ, Emson P, Faull R, Philpott KL, Harrison DC 2001 AXOR12, a novel human G protein-coupled receptor, activated by the peptide KiSS-1. J Biol Chem 276:28969-28975
Kotani M, Detheux M, Vandenbogaerde A, Communi D, Vanderwinden JM, Le Poul E, Brezillon S, Tyldesley R, Suarez-Huerta N, Vandeput F, Blanpain C, Schiffmann SN, Vassart G, Parmentier M 2001 The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54. J Biol Chem 276:34631-34636
Ohtaki T, Shintani Y, Honda S, Matsumoto H, Hori A, Kanehashi K, Terao Y, Kumano S, Takatsu Y, Masuda Y, Ishibashi Y, Watanabe T, Asada M, Yamada T, Suenaga M, Kitada C, Usuki S, Kurokawa T, Onda H, Nishimura O, Fujino M 2001 Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor. Nature 411:613-617
Navarro VM, Castellano JM, Fernández-Fernández R, Barreiro ML, Roa J, Sanchez-Criado JE, Aguilar E, Dieguez C, Pinilla L, Tena-Sempere M 2004 Developmental and hormonally regulated messenger ribonucleic acid expression of KiSS-1 and its putative receptor, GPR54, in rat hypothalamus and potent luteinizing hormone-releasing activity of KiSS-1 peptide. Endocrinology 145:4565-4574
Shahab M, Mastronardi C, Plant TM, Ojeda SR, Crowley Jr WF, Seminara SB, Hypothalamic GPR-54 expression and signaling during the peripubertal period in the rhesus monkey (Macaca mulatta). Program of the 86th Annual Meeting of The Endocrine Society, New Orleans, LA, 2004, p 529 (Abstract P3-269)
Shahab M, Mastronardi C, Seminara SB, Crowley WF, Ojeda SR, Plant TM 2005 Increased hypothalamic GPR54 signaling: a potential mechanism for initiation of puberty in primates. Proc Natl Acad Sci USA 102:2129-2134
Gottsch ML, Cunningham MJ, Smith JT, Popa SM, Acohido BV, Crowley WF, Seminara S, Clifton DK, Steiner RA 2004 A role for kisspeptins in the regulation of gonadotropin secretion in the mouse. Endocrinology 145:4073-4077
Navarro VM, Fernandez-Fernandez R, Castellano JM, Roa J, Mayen A, Barreiro ML, Gaytan F, Aguilar E, Pinilla L, Dieguez C, Tena-Sempere M 2004 Advanced vaginal opening and precocious activation of the reproductive axis by KiSS-1 peptide, the endogenous ligand of GPR54. J Physiol 561:379-386
Navarro VM, Castellano JM, Fernández-Fernández R, Tovar S, Roa J, Mayen A, Nogueiras R, Vazquez MJ, Barreiro ML, Magni P, Aguilar E, Dieguez C, Pinilla L, Tena-Sempere M 2005 Characterization of the potent luteinizing hormone-releasing activity of KiSS-1 peptide, the natural ligand of GPR54. Endocrinology 146:156-163
Irwig MS, Fraley GS, Smith JT, Acohido BV, Popa SM, Cunningham MJ, Gottsch ML, Clifton DK, Steiner RA 2005 Kisspeptin activation of gonadotropin releasing hormone neurons and regulation of KiSS-1 mRNA in the male rat. Neuroendocrinology 80:264-272
Parhar IS, Ogawa S, Sakuma Y 2004 Laser captured single digoxigenin-labeled neurons of gonadotropin-releasing hormone types reveal a novel G protein-coupled receptor (GPR54) during maturation in cichlid fish. Endocrinology 145:3613-3618
Mitsushima D, Hei DL, Terasawa E 1994 γ-Aminobutyric acid is an inhibitory neurotransmitter restricting the release of luteinizing hormone-releasing hormone before the onset of puberty. Proc Natl Acad Sci USA 91:395-399
Mitsushima D, Kimura F 1997 The maturation of GABAA receptor-mediated control of luteinizing hormone secretion in immature male rats. Brain Res 748:258-262
Mitsushima D, Marzban F, Luchansky LL, Bruich AJ, Keen KL, Durning M, Golos TG, Terasawa E 1996 Role of glutamic acid decarboxylase in the pre-pubertal inhibition of the luteinizing hormone releasing hormone release in female rhesus monkeys. J Neurosci 16:2563-2573
Keen KL, Burich AJ, Mitsushima D, Kasuya E, Terasawa E 1999 Effects of pulsatile infusion of the GABAA receptor blocker bicuculline on the onset of puberty in female rhesus monkeys. Endocrinology 140:5257-5266
Han SK, Todman MG, Herbison AE 2004 Endogenous GABA release inhibits the firing of adult gonadotropin-releasing neurons. Endocrinology 145:495-499
Urbanski HF, Rodrigues SM, Garyfallou VT, Kohama SG 1998 Regional distribution of glutamic acid decarboxylase (GAD65 and GAD 67) mRNA in the hypothalamus of male rhesus macaques before and after puberty. Mol Brain Res 57:86-91
McIntire SL, Reimer RJ, Schuske K, Edwards RH, Jorgensen EM 1997 Identification and characterization of the vesicular GABA transporter. Nature 389:870-876
Blank MS, Panerai AE, Friesen HG 1979 Opioid peptides modulate hormone secretion during sexual development. Science 203:1129-1131
Wilkinson M, Bhanot R 1982 A puberty-related attenuation of opiate peptide-induced inhibition of LH secretion. Endocrinology 110:1046-1048
Ojeda SR, Urbanski HF 1994 Puberty in the rat. In: Knobil E, Neill JD, eds. The physiology of reproduction. 2nd ed. Vol 2. New York: Raven Press; 363-409
Silverman A-J, Livne I, Witkin JW 1994 The gonadotropin-releasing hormone (GnRH), neuronal systems: immunocytochemistry and in situ hybridization. In: Knobil E, Neill JD, eds. The physiology of reproduction. 2nd ed. Vol 1. New York: Raven Press; 1683-1709
Witkin JW, Ferin M, Popilskis SJ, Silverman A-J 1991 Effects of gonadal steroids on the ultrastructure of GnRH neurons in the rhesus monkey: synaptic input and glial apposition. Endocrinology 129:1083-1092
King JC, Letourneau RL 1994 Luteinizing hormone-releasing hormone terminals in the median eminence of rats undergo dramatic changes after gonadectomy, as revealed by electron microscopic image analysis. Endocrinology 134:1340-1351
Kozlowski GP, Coates PW 1985 Ependymoneuronal specializations between LHRH fibers and cells of the cerebroventricular system. Cell Tissue Res 242:301-311
King JC, Rubin BS 1996 Recruitment of LHRH neurons and increased access of LHRH terminals to portal capillaries: integral mechanisms for LH surge induction. Ann Endocrinol (Paris) 57(Suppl 4):72
Garcia-Segura LM, McCarthy MM 2004 Minireview: role of glia in neuroendocrine function. Endocrinology 145:1082-1086
Gill JC, Moenter SM, Tsai P-S 2004 Developmental regulation of gonadotropin-releasing hormone neurons by fibroblast growth factor signaling. Endocrinology 145:3830-3839
Ma YJ, Berg-von der Emde K, Rage F, Wetsel WC, Ojeda SR 1997 Hypothalamic astrocytes respond to transforming growth factor α with secretion of neuroactive substances that stimulate the release of luteinizing hormone-releasing hormone. Endocrinology 138:19-25
Ma YJ, Hill DF, Creswick KE, Costa ME, Ojeda SR 1999 Neuregulins signaling via a glial erbB2/erbB4 receptor complex contribute to the neuroendocrine control of mammalian sexual development. J Neurosci 19:9913-9927
Prevot V, Cornea A, Mungenast A, Smiley G, Ojeda SR 2003 Activation of erbB-1 signaling in tanycytes of the median eminence stimulates transforming growth factor b1 release via prostaglandin E2 production and induces cell plasticity. J Neurosci 23:10622-10632
Ma YJ, Junier M-P, Costa ME, Ojeda SR 1992 Transforming growth factor α (TGFα) gene expression in the hypothalamus is developmentally regulated and linked to sexual maturation. Neuron 9:657-670
Apostolakis EM, Garai J, Lohmann JE, Clark JH, O'Malley BW 2000 Epidermal growth factor activates reproductive behavior independent of ovarian steroids in female rodents. Mol Endocrinol 14:1086-1098
Ma YJ, Dissen GA, Merlino G, Coquelin A, Ojeda SR 1994 Overexpression of a human transforming growth factor alpha (TGFα) transgene reveals a dual antagonistic role of TGFα in female sexual development. Endocrinology 135:1392-1400
Rage F, Hill DF, Sena-Esteves M, Breakefield XO, Coffey RJ, Costa ME, McCann SM, Ojeda SR 1997 Targeting transforming growth factor α expression to discrete loci of the neuroendocrine brain induces female sexual precocity. Proc Natl Acad Sci USA 94:2735-2740
Jung H, Carmel P, Schwartz MS, Witkin JW, Bentele KHP, Westphal M, Piatt JH, Costa ME, Cornea A, Ma YJ, Ojeda SR 1999 Some hypothalamic hamartomas contain transforming growth factor α, a puberty-inducing growth factor, but not luteinizing hormone-releasing hormone neurons. J Clin Endocrinol Metab 84:4695-4701
Prevot V, Rio C, Cho GJ, Lomniczi A, Heger S, Neville CM, Rosenthal NA, Ojeda SR, Corfas G 2003 Normal female sexual development requires neuregulin-erbB receptor signaling in hypothalamic astrocytes. J Neurosci 23:230-239
Prevot V, Lomniczi A, Corfas G, Ojeda SR 2005 ErbB-1 and erbB-4 receptors act in concert to facilitate both female sexual development and mature reproductive function. Endocrinology 146:1465-1472
Dziedzic B, Prevot V, Lomniczi A, Jung H, Cornea A, Ojeda SR 2003 Neuronto-glia signaling mediated by excitatory amino acid receptors regulates erbB receptor function in astroglial cells of the neuroendocrine brain. J Neurosci 23:915-926
Peschon JJ, Slack JL, Reddy P, Stocking KL, Sunnarborg SW, Lee DC, Russell WE, Castner BJ, Johnson RS, Fitzner JN, Boyce RW, Nelson N, Koslosky CJ, Wolfson MF, Rauch CT, Cerretti DP, Paxton RJ, March CJ, Black RA 1998 An essential role for ectodomain shedding in mammalian development. Science 282:1281-1284
Sahin U, Weskamp G, Kelly K, Zhou H-M, Higashiyama S, Peshon J, Hartmann D, Saftig P, Blobel CP 2004 Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands. J Cell Biol 164:769-779
Lomniczi A, Cornea A, Costa ME, Ojeda SR, Hypothalamic tumor necrosis factor-α converting enzyme (TACE) mediates excitatory amino acid-dependent neuron-to-glia signaling in the neuroendocrine brain. J Neurosci, in press
Roth CL, Mastronardi C, Mungenast A, Heger S, Jung H, Ojeda SR 2004 Gene expression profiling of the nonhuman primate hypothalamus at the time of female puberty reveals activation of tumor suppressor gene expression. Horm Res 62(Suppl 2):PL-69
Grumbach MM, Styne DM 2003 Puberty: ontogeny, neuroendocrinology, physiology, and disorders. In: Larsen PR, Kronenberg HM, Melmed S, Polonsky KS, eds. Williams textbook of endocrinology. 10th ed. Philadelphia: W.B. Saunders; 1115-1286
Parent AS, Jung H, Westphal M, Ojeda SR, Gene expression profiling of hypothalamic hamartomas: a search for genes involved in initiating human puberty. Program of the 87th Annual Meeting of The Endocrine Society, San Francisco, 2005, p 190 (Abstract P1-94)
Biederer T, Sara Y, Mozhayeva M, Atasoy D, Liu X, Kavalali ET, Südhof TC 2002 SynCAM, a synaptic adhesion molecule that drives synapse assembly. Science 297:1525-1531
Mungenast AE, Parent A, Chen SS, Goodlett D, Aebersold R, Corfas G, Ojeda SR 2003 The synaptic adhesion molecule SynCAM is associated with ERBB4 dysregulation in the hypothalamus of mice with a delayed onset of puberty. Program No 281 20, 2003 Abstract Viewer Washington, DC: Society for Neuroscience, 2003 Online
Kuramochi M, Fukuhara H, Nobukuni T, Kanbe T, Maruyama T, Ghosh HP, Pletcher M, Isomura M, Onizuka M, Kitamura T, Sekiya T, Reeves RH, Murakami Y 2001 TSLC1 is a tumor-suppressor gene in human non-small-cell lung cancer. Nat Genet 27:427-430
Steeg PS, Ouatas T, Halverson D, Palmieri D, Salerno M 2003 Metastasis suppressor genes: basic biology and potential clinical use. Clin Breast Cancer 4:51-62
Ojeda SR 1991 The mystery of mammalian puberty: how much more do we know? Perspect Biol Med 34:365-383
Davidson EH, Rast JP, Oliveri P, Ransick A, Calestani C, Yuh C-H, Minokawa T, Amore G, Hinman V, Arenas-mena C, Otim O, Brown CT, Livi CB, Lee PY, Revilla R, Rust AG, Pan ZJ, Schilstra MJ, Clarke PJC, Arnone MI, Rowen L, Cameron RA, McClay DR, Hood L, Bolouri H 2002 A genomic regulatory network for development. Science 295:1669-1678
Basso K, Margolin AA, Stolovitzky G, Klein U, Dalla-Favera R, Califano A 2005 Reverse engineering of regulatory networks in human B cells. Nat Genet 37:382-390
Treacy MN, Rosenfeld MG 1992 Expression of a family of POU-domain protein regulatory genes during development of the central nervous system. Annu Rev Neurosci 15:139-165
Alvarez-Bolado G, Rosenfeld MG, Swanson LW 1995 Model of forebrain regionalization based on spatiotemporal patterns of POU-III homeobox gene expression, birthdates, and morphological features. J Comp Neurol 355:237-295
Hatzopoulos AK, Stoykova AS, Erselius JR, Goulding M, Neuman T, Gruss P 1990 Structure and expression of the mouse Oct2a and Oct2b, two differentially spliced products of the same gene. Development 109:349-362
Ojeda SR, Hill J, Hill DF, Costa ME, Tapia V, Cornea A, Ma YJ 1999 The Oct-2 POU-domain gene in the neuroendocrine brain: a transcriptional regulator of mammalian puberty. Endocrinology 140:3774-3789
Kimura S, Hara Y, Pineau T, Fernandez-Salguero P, Fox CH, Ward JM, Gonzalez FJ 1996 The T/ebp null mouse: thyroid-specific enhancer-binding protein is essential for the organogenesis of the thyroid, lung, ventral forebrain, and pituitary. Genes Dev 10:60-69
Lee BJ, Cho GJ, Norgren R, Junier M-P, Hill DF, Tapia V, Costa ME, Ojeda SR 2001 TTF-1, a homeodomain gene required for diencephalic morphogenesis, is postnatally expressed in the neuroendocrine brain in a developmentally regulated and cell-specific fashion. Mol Cell Neurosci 17:107-126
Mastronardi C, Smiley G, Kuswakabe T, Kawagushi A, Cabrera R, Mungenast A, Kimura S, Ojeda SR 2004 Neuronal deletion of the T/EBP gene delays female puberty and causes premature reproductive senescence. Program No 143 2, 2004 Abstract Viewer Washington, DC: Society for Neuroscience, 2004 Online
Ojeda SR, Lomniczi A, Mungenast A, Mastronardi C, Parent AS, Roth C, Prevot V, Heger S, Jung H 2005 Towards understanding the neurobiology of mammalian puberty: genetic, genomic and proteomic approaches. In: Kordon C, Gaillard R, Christen Y, eds. Hormones and the brain. Berlin: Springer Verlag; 47-60
Rampazzo A, Pivotto F, Occhi G, Tiso N, Bortoluzzi S, Rowen L, Hood L, Nava A, Danieli GA 2000 Characterization of C14orf4, a novel intronless human gene containing a polyglutamine repeat, mapped to the ARVD1 critical region. Biochem Biophys Res Commun 278:766-774
Heger S, Mastronardi C, Lomniczi A, Cabrera R, Roth C, Sippell WG, Jung H, Dissen GA, Ojeda SR 2005 Role of a novel gene (enhanced at puberty, EAP-1) in the regulation of female puberty. Horm Res 64(Suppl 1):22
Krewson TD, Supelak PJ, Hill AE, Singer JB, Lander ES, Nadeau JH, Palmert MR 2004 Chromosomes 6 and 13 harbor genes that regulate pubertal timing in mouse chromosome substitution strains. Endocrinology 145:4447-4451
Seminara SB, Crowley Jr WF 2001 Perspective: the importance of genetic defects in humans in elucidating the complexities of the hypothalamic-pituitary- gonadal axis. Endocrinology 142:2173-2177
Eaves L, Silberg J, Foley D, Bulik C, Maes H, Erkanli A, Angold A, Costello EJ, Worthman C 2004 Genetic and environmental influences on the relative timing of pubertal change. Twin Res 7:471-481
Chesler EJ, Lu L, Shou S, Qu Y, Gu J, Wang J, Hsu HC, Mountz JD, Baldwin NE, Langston MA, Threadgill DW, Manly KF, Williams RW 2005 Complex trait analysis of gene expression uncovers polygenic and pleiotropic networks that modulate nervous system function. Nat Genet 37:233-242
de Vries L, Kauschansky A, Shohat M, Phillip M 2004 Familial central precocious puberty suggests autosomal dominant inheritance. J Clin Endocrinol Metab 89:1794-1800
