Control of puberty by excitatory amino acid neurotransmitters and its clinical implications

[en] Excitatory amino acids, glutamate in particular, have a marked stimulatory effect on the reproductive axis, particulary at puberty. Glutamate, N-methyl-D-aspartate (NMDA), and kainate stimulate gonadotropin-releasing hormone (GnRH) secretion in immature mammals and NMDA receptor stimulation results in precocious puberty in rats and monkeys. Puberty is characterized by an increased sensitivity of GnRH to glutamate as well as an increase in glutaminase activity in the hypothalamus. Glutamatergic and GABAergic regulation of GnRH secretion seem strongly interdependent around puberty. in addition to the transsynaptic glutamatergic regulation of GnRH secretion, a coordinated activity of glutamatergic neurons and astroglial cells has been shown to play an active role in puberty. The participation of kainate receptors in the estradiol-induced advancement of puberty suggest that these receptors may be involved in the estradiol-mediated activation of GnRH secretion at puberty. A case of precocious puberty associated with hyperglycinemia illustrates the NMDA involvement in puberty in humans. in this patient, the occurrence of precocious puberty was thought to result from excessive stimulation by glycine of the NMDA receptors linked to the GnRH neurons. Glutamate plays several roles in the hypothalamic mechanism of puberty as it has been shown in animal models, but there are still few clinical data supporting the role of glutamate in human puberty.

Research center :

Giga-Neurosciences - ULiège

Disciplines :

Endocrinology, metabolism & nutrition

Author, co-author :

Parent, Anne-Simone ; Université de Liège - ULiège > Département des sciences cliniques > Pédiatrie

Matagne, V.

Bourguignon, Jean-Pierre ; Université de Liège - ULiège > Département des sciences cliniques > Pédiatrie

Language :

English

Title :

Control of puberty by excitatory amino acid neurotransmitters and its clinical implications

Publication date :

December 2005

Journal title :

Endocrine Journal

ISSN :

0969-711X

Publisher :

Humana Press Inc, Totowa, United States - New Jersey

Volume :

Issue :

Pages :

281-285

Peer reviewed :

Peer reviewed

Funders :

F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
BSGPE - Belgian Study Group for Pediatric Endocrinology [BE]
NIH - National Institutes of Health [US-MD]

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since 19 November 2010

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Bibliography

Van den Pol, A. N. and Trombley, P. Q. (1993). J. Neurosci. 13, 2829-2836.
Goldsmith, P. C., Thind, K. K., Perera, A. D., and Plant, T. M. (1994). Endocrinology 134, 858-868.
Leranth, C., Naftolin, F., Shanabrough, M., and Horvath, T. L. (1995). In: The neurobiology of puberty. Plant, T. M. and Lee, P. A. (eds.). Journal of Endocrinology: Bristol, UK.
Ojeda, S. R. and Terasawa, E. (2002). Hormones, Brain and Behavior 4, 589-659.
Goroll, D., Arias, P., and Wuttke, W. (1994). Brain Res. Dev. Brain Res. 77, 183-188.
Carbone, S., Szwarcfarb, B., Otero, L. M., and Moguilevsky, J. (1992). Endocrinology 130, 1365-1370.
Carbone, S., Szwarcfarb, B., Losada, M., and Moguilevsky, J. (1995). Neuroendocrinology 61, 235-242.
Goroll, D., Arias, P., and Wuttke, W. (1993). Neuroendocrinology 58, 11-15.
Bourguignon, J. P., Gérard, A., and Franchimont, P. (1989). Neuroendocrinology 49, 402-408.
Cicero, T. J., Meyer, E. R., and Bell, R. D. (1988). Life Sci. 42, 1725-1732.
Urbanski, H. F. and Ojeda, S. R. (1987). Neuroendocrinology 46, 273-276.
Gay, V. L. and Plant, T. (1987). Endocrinology 120, 2289-2296.
Medhamurthy, R., Dichek, H. L., Plant, T. M., Bernardini, I., and Cutler, G. B. (1990). J. Clin. Endocrinol. Metab. 71, 1390-1392.
Bettendorf, M., de Zegher, F., Albers, N., Hart, C. S., Kaplan, S. L., and Grumbach, M. M. (1999). Horm. Res. 51, 25-30.
Smyth, C. and Wilkinson, M. (1994). J. Neuroendocrinol. 6, 275-284.
Plant, T. M., Gay, V. L., Marshall, G. R., and Arslan, M. (1989). Proc. Natl. Acad. Sci. USA 86, 2506-2510.
McDonald, M.C. and Wilkinson, M. (1990). Neuroendocrinology 52, 143-149.
Urbansky, H. F. and Ojeda, S. R. (1990). Endocrinology 126, 1774-1776.
Franklin, S. O., Elliott, K., Zhu, Y.-S., Wahlestedt, C., and Inturrisi, C. E. (1993). Mol. Brain Res. 19, 93-100.
Sheng, M., Cummings, J., Roldan, L. A., Jan, Y. N., and Jan, L. Y. (1994). Nature 368, 144-147.
Zhong, J., Carrozza, D. P., Williams, K., Pritchett, D. B., and Molinoff, P. B. (1995). J. Neurochem. 64, 531-539.
Adams, M. M., Flagg, R. A., and Gore, A. C. (1999). Endocrinology 140, 2288-2296.
Bahn, S., Volk, B., and Wisden, W. (1994). J. Neurosci. 14, 5525-5547.
Parent, A. S., Lebrethon, M. C., Gérard, A., and Bourguignon, J. P. (2005). Biol. Reprod. 72, 143-149.
Bernard, A., Ferhat, L., Dessi, F., et al. (1999). Eur. J. Neurosci. 11, 604-616.
Bourguignon, J. P., Gérard, A., Mathieu, J., Mathieu, A., and Franchimont, P. (1990). Endocrinology 127, 873-881.
Bourguignon, J. P., Gérard, A., and Franchimont, P. (1990). Endocrinology 127, 2884-2890.
Gore, A. C., Wu, T. J., Rosenberg, J. J., and Roberts, J. L. (1996). J. Neurosci. 16, 5281-5289.
Bourguignon, J. P., Gérard, A., Alvarez Gonzalez, M. L., and Franchimont, P. (1992). J. Clin. Invest. 90, 1736-1744.
Bourguignon, J. P., Gérard, A., Alvarez Gonzalez, M. L., Fawe, L., and Franchimont, P. (1992). Neuroendocrinology 55, 634-641.
Kvamme, E. (1983). In: Glutamine, glutamate and GABA in the central nervous system. Hertz, L., Kvamme, E., Mc Geer, E., and Schousboe, A. (eds.). Liss: New York, pp. 51-57.
Bourguignon, J. P., Gérard, A., Alvarez Gonzalez, M. L., Purnelle, G., and Franchimont, P. (1995). Endocrinology 136, 911-916.
Roth, C., Leonhardt, S., Theiling, K., Lakomek, M., Jarry, H., and Wuttke, W. (1998). Brain Res. Dev. Brain Res. 110, 105-114.
Bourguignon, J. P., Alvarez Gonzalez, M. L., Gérard, A., and Franchimont, P. (1994). Endocrinology 143, 1589-1592.
Yamanaka, C., Lebrethon, M. C., Vandersmissen, E., et al. (1999). Endocrinology 140, 4609-4615.
Ordog, T., Chen, M. D., Nishihara, M., Connaughton, M. A., Goldsmith, J. R., and Knobil, E. (1997). Neuroendocrinology 65, 307-313.
Rodriguez-Moreno, A. and Lerma, J. (1998). Neuron 20, 1211-1218.
Min, M. Y., Melyan, Z., and Kullmann, D. M. (1999). Proc. Natl. Acad. Sci. USA 96, 9932-9937.
Satake, S., Saitow, F., Yamada, J., and Konishi, S. (1998). Nat. Neurosci. 3, 551-558.
Bourguignon, J. P., Gérard, A., Purnelle, G., et al. (1997). J. Neuroendocrinol. 9, 183-191.
Bourguignon, J. P., Gérard, A., Purnelle, G., et al. (1997). J. Neuroendocrinol. 9, 193-199.
Ma, Y. J., Berg-von der Emde, K., Rage, F., Wetsel, W. C., and Ojeda, S. R. (1997). Endocrinology 138, 19-25.
Ma, Y. J., Hill, D. F., Creswick, K. E., Costa, M. E., and Ojeda, S. R. (1999). J. Neurosci. 19, 9913-9927.
Rage, F., Lee, B. J., Ma, Y. J., and Ojeda, S. R. (1997). J. Neurosci. 17, 9145-9156.
Blakenfeld, G. V. and Kettenmann, H. (1991). Mol. Neurobiol. 5, 31-43.
Gallo, V. and Ghiani, C. A. (2000). Trends Pharmacol. Sci. 21, 252-258.
Dziedzic, B., Prevot, V., Lomniczi, A., Jung, H., Cornea, A., and Ojeda, S. R. (2003). J. Neurosci. 23, 915-926.
Ojeda, S. R., Lomniczi, A., Mungenast, A., et al. (2005). In: Hormones and the brain. Kordon, C. (ed.). Springer-Verlag: Berlin, pp. 47-60.
Herbison, A. E. (1998). Endocr. Rev. 19, 302-330.
Xia, L., Van Vugt, D. A., Alston, E. J., Luckhaus, J., and Ferin, M. (1992). Endocrinology 131, 2812-2820.
Dorling, A. A., Todman, M. G., Korach, K. S., and Herbison, E. (2003). Neuroendocrinology 78, 204-209.
Mc Ewen, B. (2002). Rec. Prog. Horm. Res. 57, 357-384.
Hrabovszky, E., Steinhauser, A., Barabas, K., et al. (2001). Endocrinology 142, 3261-3264.
Kallo, I., Butler, J. A., Barkovics-Kallo, M., Goubillon, M. L., and Coen, C. W. (2001). J. Neuroendocrinol. 13, 741-748.
Herbison, A. E. and Pape, J. R. (2001). Front. Neuroendocrinol. 22, 292-308.
Parent, A. S., Teilmann, G., Juul, A., Skakkebaek, N. E., Toppari, J., and Bourguignon, J. P. (2003). Endocr. Rev. 24, 668-693.
Ramirez, V. D. and Sawyer, C. H. (1965). Endocrinology 76, 1158-1168.
Ojeda, S. R., Urbanski, H. F., Katz, K. H., and Costa, M. E. (1986). Neuroendocrinology 43, 259-265.
Matagne, V., Rasier, G., Lebrethon, M. C., Gérard, A., and Bourguignon, J. P. (2004). Endocrinology 145, 2775-2783.
Medhamurthy, R., Gay, V. L., and Plant, T. (1992). Neuroendocrinology 55, 660-666.
Brann, D. W., Zamorano, P. L., Ping, L., and Mahesh, V. B. (1993). Mol. Cell. Neurosci. 4, 107-112.
Eyigor, O. and Jennes, L. (2000). Endocrinology 141, 779-786.
Lopez, F. J., Donoso, A. O., and Negro-Vilar, A. (1990). Endocrinology 126, 1771-1773.
Bourguignon, J. P., Jaeken, J., Gérard, A., and de Zegher, F. (1997). J. Clin. Endocrinol. Metab. 82, 1899-1903.
Hamosh, A., Johnston, M. V., and Valle, D. In: The metabolic and molecular basis of inherited disease, 7th ed. Scriver, C. R., Beaudet, A. L., Sly, W. S., and Valle, D. (eds.). McGraw-Hill: New York, pp. 1337-1348.
Johnson, J. W. and Ascher, P. (1987). Nature 325, 529-531.
Burde, R. M., Schainker, B., and Kayes, J. (1971). Nature 233, 58-60.