Article (Scientific journals)
Type II collagen markers in osteoarthritis: what do they indicate?
Henrotin, Yves; Addison, Shelby; Kraus, Virginia et al.
2007In Current Opinion in Rheumatology, 19 (5), p. 444-50
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Keywords :
biomarkers; cartilage; osteoarthritis; Animals; Biological Markers; Cartilage/metabolism; Collagen Type II/chemistry/metabolism/urine; Disease Models, Animal; Humans; Osteoarthritis/diagnosis/drug therapy/physiopathology
Abstract :
[en] PURPOSE OF REVIEW: We provide a critical review of recent in-vitro, animal and human clinical studies on type II collagen biomarkers. In describing the human studies, we have applied the BIPED (burden of disease, investigative, prognostic, efficacy of intervention, and diagnostic) classification scheme recently proposed by the Osteoarthritis Biomarkers Network (a consortium of five US National Institutes of Health designated sites). Based on this analysis, we propose an update to the classification of the type II collagen biomarkers. RECENT FINDINGS: Various type II collagen epitopes have been described as potential biomarkers for osteoarthritis. Some have demonstrated ability in the following areas: classification of individuals as either diseased or nondiseased; assessment of severity or extent of osteoarthritis; prediction of future onset of osteoarthritis among those without osteoarthritis at baseline or the progression of osteoarthritis among those with existing disease; and monitoring treatment efficacy. SUMMARY: Type II collagen biomarkers provide useful information for clinical and research applications. Furthermore, they are promising tools for the monitoring the influence of drug treatment on cartilage metabolism in joint diseases such as osteoarthritis.
Disciplines :
Rheumatology
Author, co-author :
Henrotin, Yves  ;  Université de Liège - ULiège > Département des sciences de la motricité > Unité de recherche sur l'os et le cartillage (U.R.O.C.) - Didactique des sciences de la santé - Pathologie générale et physiopathologie
Addison, Shelby
Kraus, Virginia
Deberg, Michelle ;  Université de Liège - ULiège > Département des sciences de la motricité > Unité de recherche sur l'os et le cartillage (U.R.O.C.)
Language :
English
Title :
Type II collagen markers in osteoarthritis: what do they indicate?
Publication date :
2007
Journal title :
Current Opinion in Rheumatology
ISSN :
1040-8711
eISSN :
1531-6963
Publisher :
Lippincott Williams & Wilkins, Philadelphia, United States - Pennsylvania
Volume :
19
Issue :
5
Pages :
444-50
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 12 November 2010

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