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Type II collagen markers in osteoarthritis: what do they indicate?

Henrotin, Yves; Addison, Shelby; Kraus, Virginia et al.

2007 • In Current Opinion in Rheumatology, 19 (5), p. 444-50

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/75563

DOI
10.1097/BOR.0b013e32829fb3b5

PubMed
17762609

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Keywords :

biomarkers; cartilage; osteoarthritis; Animals; Biological Markers; Cartilage/metabolism; Collagen Type II/chemistry/metabolism/urine; Disease Models, Animal; Humans; Osteoarthritis/diagnosis/drug therapy/physiopathology

Abstract :

[en] PURPOSE OF REVIEW: We provide a critical review of recent in-vitro, animal and human clinical studies on type II collagen biomarkers. In describing the human studies, we have applied the BIPED (burden of disease, investigative, prognostic, efficacy of intervention, and diagnostic) classification scheme recently proposed by the Osteoarthritis Biomarkers Network (a consortium of five US National Institutes of Health designated sites). Based on this analysis, we propose an update to the classification of the type II collagen biomarkers. RECENT FINDINGS: Various type II collagen epitopes have been described as potential biomarkers for osteoarthritis. Some have demonstrated ability in the following areas: classification of individuals as either diseased or nondiseased; assessment of severity or extent of osteoarthritis; prediction of future onset of osteoarthritis among those without osteoarthritis at baseline or the progression of osteoarthritis among those with existing disease; and monitoring treatment efficacy. SUMMARY: Type II collagen biomarkers provide useful information for clinical and research applications. Furthermore, they are promising tools for the monitoring the influence of drug treatment on cartilage metabolism in joint diseases such as osteoarthritis.

Disciplines :

Rheumatology

Author, co-author :

Henrotin, Yves ; Université de Liège - ULiège > Département des sciences de la motricité > Unité de recherche sur l'os et le cartillage (U.R.O.C.) - Didactique des sciences de la santé - Pathologie générale et physiopathologie

Addison, Shelby

Kraus, Virginia

Deberg, Michelle ; Université de Liège - ULiège > Département des sciences de la motricité > Unité de recherche sur l'os et le cartillage (U.R.O.C.)

Language :

English

Title :

Type II collagen markers in osteoarthritis: what do they indicate?

Publication date :

2007

Journal title :

Current Opinion in Rheumatology

ISSN :

1040-8711

eISSN :

1531-6963

Publisher :

Lippincott Williams & Wilkins, Philadelphia, United States - Pennsylvania

Volume :

19

Issue :

5

Pages :

444-50

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 12 November 2010

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2 (1 by ULiège)

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Scopus citations^®

91

Scopus citations^®
without self-citations

65

OpenCitations

75

OpenAlex citations

103

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