Article (Scientific journals)
Close-packed array of gold nanoparticles and Sum Frequency Generation spectroscopy in total internal reflection: A platform for studying biomolecules and biosensors
Tourillon, Gérard; Dreesen, Laurent; Volcke, Cédric et al.
2009In Journal of Materials Science, 44 (24), p. 6805-6810
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Keywords :
nanoparticles; sum-frequency generation; biosensor
Abstract :
[en] An approach is introduced for studying the adsorption and recognition mechanisms of biomolecules, without using any markers. We show for the first time, that the Sum Frequency Generation spectroscopy performed in the Total Internal Reflection (TIR-SFG) geometry, combined with a regular close-packed array of gold nanoparticles allows to probe with a high sensitivity the changes in conformation and orientation induced by the recognition process of avidin by biocytin. This approach represents a new platform with potential use in biosensors, diagnostics and bioactive layers.
Disciplines :
Physics
Author, co-author :
Tourillon, Gérard
Dreesen, Laurent ;  Université de Liège - ULiège > Département de physique > Biophotonique
Volcke, Cédric
Sartenaer, Yannick
Thiry, Paul A.
Peremans, André
Language :
English
Title :
Close-packed array of gold nanoparticles and Sum Frequency Generation spectroscopy in total internal reflection: A platform for studying biomolecules and biosensors
Publication date :
2009
Journal title :
Journal of Materials Science
ISSN :
0022-2461
eISSN :
1573-4803
Publisher :
Springer
Volume :
44
Issue :
24
Pages :
6805-6810
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 10 November 2010

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