Aged; Biological Markers/blood; Collagen Type II/blood; DNA, Mitochondrial/genetics; Female; Haplotypes; Humans; Hyaluronic Acid/blood; Male; Middle Aged; Osteoarthritis, Hip/blood/genetics/radiography; Osteoarthritis, Knee/blood/genetics/radiography; Peptide Fragments/blood; Retrospective Studies; Severity of Illness Index
Abstract :
[en] OBJECTIVE: To analyse the influence of mitochondrial DNA (mtDNA) haplogroups on serum levels of molecular biomarkers in patients with osteoarthritis (OA). METHODS: Serum levels of molecular biomarkers of cartilage metabolism (collagen type II markers: C-terminal neoepitope generated by the collagenase-mediated cleavage of collagen type II triple helix (C2C), collagen type II (Coll2-1, and its nitrated form, Coll2-1NO(2)), procollagen type II (CPII)), synovial metabolism (hyaluronic acid (HA)) and cartilage and synovial turnover (cartilage glycoprotein 39 (YKL-40)) were analysed in 73 patients with OA and 77 healthy controls using ELISAs. All participants had been previously genotyped for the mtDNA haplogroups J, U and H. Non-parametric and multivariate analysis were performed to test the effects of the clinical variables, including gender, age, smoking status, diagnosis, mtDNA haplogroups and radiological Kellgren and Lawrence (K/L) grade on the serum levels of the molecular markers. RESULTS: Non-parametric analysis found increased serum levels of HA in patients with OA, while the values for C2C and the C2C/CPII ratio were significantly higher in the healthy controls. A multiple regression analysis showed a relationship between the mtDNA haplogroups and serum levels of the typical collagen type II markers. Carriers of the mtDNA haplogroup H had higher levels while carriers of the mtDNA haplogroup J showed lower levels. Statistically significant interactions between mtDNA haplogroups and diagnosis and between mtDNA haplogroups and radiological K/L grade in the serum levels of molecular markers were also found. CONCLUSION: A new role for mtDNA haplogroups emerges from this work. The results suggest that the mtDNA haplogroups interact significantly with the serum levels of OA-related molecular markers, suggesting the possibility of their use as a complementary assay with these molecular markers.
Disciplines :
Rheumatology
Author, co-author :
Rego-Perez, I.
Fernandez-Moreno, M.
Deberg, Michelle ; Université de Liège - ULiège > Département des sciences de la motricité > Unité de recherche sur l'os et le cartillage (U.R.O.C.)
Pertega, S.
Fenandez-Lopez, C.
Oreiro, N.
Henrotin, Yves ; Université de Liège - ULiège > Département des sciences de la motricité > Unité de recherche sur l'os et le cartillage (U.R.O.C.) - Didactique des sciences de la santé - Pathologie générale et physiopathologie
Blanco, F. J.
Language :
English
Title :
Mitochondrial DNA haplogroups modulate the serum levels of biomarkers in patients with osteoarthritis.
scite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports, mentions, or contrasts the cited claim, and a label indicating in which section the citation was made.
Bibliography
Felson DT, Zhang Y. An update on the epidemiology of knee and hip osteoarthritis with a view to prevention. Arthritis Rheum 1998;41:1343-1355 (Pubitemid 28373113)
Blackburn WD Jr, Chivers S, Bernreuter W. Cartilage imaging in osteoarthritis. Semin Arthritis Rheum 1996;25:273-281
Ravaud P, Giraudeau B, Auleley GR, et al. Variability in knee radiographing: implication for definition of radiological progression in medial knee osteoarthritis. Ann Rheum Dis 1998;57:624-629 (Pubitemid 28513142)
Garnero P, Ayral X, Rousseau JC, et al. Uncoupling of type II collagen synthesis and degradation predicts progression of joint damage in patients with knee osteoarthritis. Arthritis Rheum 2002;46:2613-2624 (Pubitemid 36118924)
Garnero P, Piperno M, Gineyts E, et al. Cross sectional evaluation of biochemical markers of bone, cartilage, and synovial tissue metabolism in patients with knee osteoarthritis: relations with disease activity and joint damage. Ann Rheum Dis 2001;60:619-626 (Pubitemid 32493990)
Christgau S, Garnero P, Fledelius C, et al. Collagen type II C-telopeptide fragments as an index of cartilage degradation. Bone 2001;29:209-215 (Pubitemid 32823562)
Henrotin Y, Addison S, Kraus V, et al. Type II collagen markers in osteoarthritis: what do they indicate? Curr Opin Rheumatol 2007;19:444-450 (Pubitemid 47344236)
Terkeltaub R, Johnson K, Murphy A, et al. Invited review: the mitochondrion in osteoarthritis. Mitochondrion 2002;1:301-319
Maneiro E, Martín MA, de Andres MC, et al. Mitochondrial respiratory activity is altered in osteoarthritic human articular chondrocytes. Arthritis Rheum 2003;48:700-708 (Pubitemid 36302006)
Kim HA, Blanco FJ. Cell death and apoptosis in osteoarthritic cartilage. Curr Drug Targets 2007;8:333-345 (Pubitemid 46299681)
Cillero-Pastor B, Caramés B, Lires-Deán M, et al. Mitochondrial dysfunction activates cyclooxygenase 2 expression in cultured normal human chondrocytes. Arthritis Rheum 2008;58:2409-2419
Blanco FJ, López-Armada MJ, Maneiro E. Role of mitochondria and Osteoarthritis. Mitochondrion 2004;4:715-728
Henrotin Y, Kurz B. Antioxidant to treat osteoarthritis: dream or reality? Curr Drug Targets 2007;8:347-357 (Pubitemid 46299682)
Grishko VI, Ho R, Wilson GL, et al. Diminished mitochondrial DNA integrity and repair capacity in OA chondrocytes. Osteoarthr Cartil 2009;17:107-113
Rego-Pérez I, Fernández-Moreno M, Fernández- López C, et al. Mitochondrial DNA haplogroups: role in the prevalence and severity of knee osteoarthritis. Arthritis Rheum 2008;58:2387-2396
Rego I, Fernández-Moreno M, Fernández-López C, et al. Role of European mtDNA haplogroups in the prevalence of hip osteoarthritis in Galicia (Northern Spain). Ann Rheum Dis 2009;2010;69:210-213.
Ruiz-Pesini E, Mishmar D, Brandon M, et al. Effects of purifying and adaptive selection on regional variation in human mtDNA. Science 2004;303:223-226 (Pubitemid 38057570)
Altman R, Asch E, Bloch D, et al. Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association. Arthritis Rheum 1986;29:1039-1049
Kellgren JH, Lawrence JS. Radiological assessment of osteo-arthrosis. Ann Rheum Dis 1957;16:494-502.
Deberg M, Labasse A, Christgau S, et al. New serum biochemical markers (Coll 2-1 and Coll 2-1 NO2) for studying oxidative-related type II collagen network degradation in patients with osteoarthritis and rheumatoid arthritis. Osteoarthr Cartil 2005;13:258-265 (Pubitemid 40277284)
Torroni A, Huoponen K, Francalacci P, et al. Classification of European mtDNAs from an analysis of three European populations. Genetics 1996;144:1835-1850 (Pubitemid 26427929)
Elliott AL, Kraus VB, Luta G, et al. Serum hyaluronan levels and radiographic knee and hip osteoarthritis in African Americans and Caucasians in the Johnston County Osteoarthritis Project. Arthritis Rheum 2005;52:105-111 (Pubitemid 40129238)
Mazières B, Garnero P, Guéguen A, et al. Molecular markers of cartilage breakdown and synovitis at baseline as predictors of structural progression of hip osteoarthritis. The ECHODIAH Cohort. Ann Rheum Dis 2006;65:354-359 (Pubitemid 43268225)
Deberg M, Dubuc JE, Labasse A, et al. One-year follow-up of Coll2-1, Coll2-1NO2 and myeloperoxydase serum levels in osteoarthritis patients after hip or knee replacement. Ann Rheum Dis 2008;67:168-174 (Pubitemid 351183304)
Sharma L, Dunlop D, Ionescu M. The ratio of collagen breakdown to collagen synthesis and its relationship with the progression of knee osteoarthritis. Arthritis Rheum 2004;50:S282.
Manicourt DH, Azria M, Mindeholm L, et al. Oral salmon calcitonin reduces Lequesne's algofunctional index scores and decreases urinary and serum levels of biomarkers of joint metabolism in knee osteoarthritis. Arthritis Rheum 2006;54:3205-3211 (Pubitemid 44622091)
Dahmany Y, Marcuello A, Montiel-Sosa FJ, et al. Mitochondrial lineages distribution in the Spanish population: anticipating association studies. An R Acad Nac Farm 2006;72:37-47. (Pubitemid 44077202)
Ruiz-Pesini E, Lapeña AC, Díez-Sánchez C, et al. Human mtDNA haplogroups associated with high or reduced spermatozoa motility. Am J Hum Genet 2000;67:682-696 (Pubitemid 30659599)
López-Armada MJ, Caramés B, Martín MA, et al. Mitochondrial activity is modulated by TNFalpha and IL-1beta in normal human chondrocyte cells. Osteoarthritis Cartilage 2006;14:1011-1022
Maneiro E, López-Armada MJ, de Andres MC, et al. Effect of nitric oxide on mitochondrial respiratory activity of human articular chondrocytes. Ann Rheum Dis 2005;64:388-395 (Pubitemid 40283048)
Johansen JS, Hvolris J, Hansen M, et al. Serum YKL-40 levels in healthy children and adults. Comparison with serum and synovial fluid levels of YKL-40 in patients with osteoarthritis or trauma of the knee joint. Br J Rheumatol 1996;35:553-559 (Pubitemid 126719486)
Johansen JS, Olee T, Price PA, et al. Regulation of YKL-40 production by human articular chondrocytes. Arthritis Rheum 2001;44:826-837 (Pubitemid 32319775)
Similar publications
Sorry the service is unavailable at the moment. Please try again later.
This website uses cookies to improve user experience. Read more
Save & Close
Accept all
Decline all
Show detailsHide details
Cookie declaration
About cookies
Strictly necessary
Performance
Strictly necessary cookies allow core website functionality such as user login and account management. The website cannot be used properly without strictly necessary cookies.
This cookie is used by Cookie-Script.com service to remember visitor cookie consent preferences. It is necessary for Cookie-Script.com cookie banner to work properly.
Performance cookies are used to see how visitors use the website, eg. analytics cookies. Those cookies cannot be used to directly identify a certain visitor.
Used to store the attribution information, the referrer initially used to visit the website
Cookies are small text files that are placed on your computer by websites that you visit. Websites use cookies to help users navigate efficiently and perform certain functions. Cookies that are required for the website to operate properly are allowed to be set without your permission. All other cookies need to be approved before they can be set in the browser.
You can change your consent to cookie usage at any time on our Privacy Policy page.