SPICE-Circuit Simulation of the Electrical Response of a Semiconductor Membrane to a Single-Stranded DNA Translocating Through a Nanopore

Leroux, Amandine; Destiné, Jacques; Vanderheyden, Benoît; Gracheva, Maria; Leburton, Jean-Pierre

doi:10.1109/TNANO.2010.2043957

Article (Scientific journals)

SPICE-Circuit Simulation of the Electrical Response of a Semiconductor Membrane to a Single-Stranded DNA Translocating Through a Nanopore

Leroux, Amandine; Destiné, Jacques; Vanderheyden, Benoît et al.

2010 • In IEEE Transactiones on Nanotechnology, 9 (3), p. 322-329

Peer reviewed

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https://hdl.handle.net/2268/74015

DOI
10.1109/TNANO.2010.2043957

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Keywords :

Circuit modeling; DNA sequencing; Solid-state nanopore; Spice simulation

Abstract :

[en] In this paper, we describe a circuit-element model for the electric detection of biomolecules in translocation through a nanopore in a semiconductor-oxide-semiconductor (SOS) membrane. The biomolecules are simulated as a superposition of individual charges moving through the nanopore and inducing a charge variation on the membrane electrodes that is modeled as a current source. The SOS membrane is discretized into interconnected elementary circuit elements. The model is tested on the translocation of 11 base single-stranded C3AC7 DNA molecule, for which the electric signal shows good qualitative agreement with the multiscale device approach of Gracheva et al., while quantifying the low-pass filtering in the membrane. Overall, the model confirms the possibility of identifying the sequence of the DNA bases electrically.

Disciplines :

Electrical & electronics engineering

Author, co-author :

Leroux, Amandine ; Université de Liège - ULiège > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Dép. d'électric., électron. et informat. (Inst.Montefiore)

Destiné, Jacques ; Université de Liège - ULiège > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Electronique, microsystèmes, mesures et instrumentation

Vanderheyden, Benoît ; Université de Liège - ULiège > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Electronique et microsystèmes

Gracheva, Maria; Clarkson University > Department of Physics

Leburton, Jean-Pierre; University of Illinois at Urbana-Champaign > Beckman Institute for Advanced Science and Technology and Department of Electrical Engineering

Language :

English

Title :

SPICE-Circuit Simulation of the Electrical Response of a Semiconductor Membrane to a Single-Stranded DNA Translocating Through a Nanopore

Publication date :

May 2010

Journal title :

IEEE Transactiones on Nanotechnology

Volume :

Issue :

Pages :

322-329

Peer reviewed :

Peer reviewed

Available on ORBi :

since 17 October 2010

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