La creatinine : d'hier a aujourd'hui.

[en] Serum creatinine is certainly one of the most prescribed biological parameters. In this review article, we remind some historical data regarding creatinine. Different methodologies to measure creatinine in blood and urine are deeply described. We also discuss the physiological reason for its use as a glomerular filtration rate marker. However, analytical and physiological limitations are described and discussed. Creatinine clearance usefulness is finally largely discussed.

Disciplines :

Laboratory medicine & medical technology
Urology & nephrology

Author, co-author :

Delanaye, Pierre ; Centre Hospitalier Universitaire de Liège - CHU > Néphrologie

Cavalier, Etienne ; Centre Hospitalier Universitaire de Liège - CHU > Chimie médicale

Maillard, Nicolas

Krzesinski, Jean-Marie ; Centre Hospitalier Universitaire de Liège - CHU > Néphrologie

Mariat, Christophe

Cristol, Jean-Paul

Pieroni, Laurence

Language :

French

Title :

La creatinine : d'hier a aujourd'hui.

Alternative titles :

[en] Creatinine: past and present.

Publication date :

2010

Journal title :

Annales de Biologie Clinique

ISSN :

0003-3898

eISSN :

1950-6112

Publisher :

John Libbey Eurotext, Montrouge, France

Volume :

Issue :

Pages :

531-43

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

http://www.john-libbey-eurotext.fr/fr/revues/bio_rech/abc/e-docs/00/04/5D/A5/resume.phtml

Available on ORBi :

since 11 October 2010

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Bibliography

Liebig J. Kreatin und Kreatinin, Bestandtheile des Harns der Menschen. J Prakt Chem 1847 ; 40 : 288-92.
Möller E, McIntosh JF, Van Slycke DD. Studies of urea excretion. II. Relationship between urine volume and the rate of urea excretion by normal adults. J Clin Invest 1929 ; 6 : 427-65.
Rehberg PB. Studies on kidney function : the rate of filtration and reabsorption in the human kidney. Biochem J 1926 ; 20 : 447-60.
Smith HW. The kidney : structure and function in health and disease. New York : Oxford University Press Inc, 1951.
Shannon JA. The renal excretion of creatinine in man. J Clin Invest 1935 ; 14 : 403-10.
Miller BF, Winkler AW. The renal excretion of endogenous creatinine in man. Comparison with exogenous creatinine and inulin. J Clin Invest 1938 ; 17 : 31-40.
Jaffe M. Ueber den Neiderschlag, welchen Pikrinsäre in normalen Harn erzeugt und über eine neue Reaktion des Kreatinins. Z Physiol Chem 1886 ; 10 : 391-400.
Johnson G. Some common sources of errors in testing for sugar in the urine. Lancet 1894 ; 144 : 11-3.
Colls PC. Notes on creatinine. J Physiol 1896 ; 20 : 107-11.
Folin O. Approximately complete analyses of thirty "normal" urines. Am J Physiol 1905 ; 13 : 45-65.
Gaebler OH. Further studies of blood creatinine. J Biol Chem 1930 ; 89 : 451-66.
Hayman JM, Johnston SM, Bender JA. On the presence of creatinine in blood. J Biol Chem 1935 ; 108 : 675-91.
Hunter A, Campbell WR. The probable accuracy, in whole blood and plasma, of colorimetric determinations of creatinine and creatine. J Biol Chem 1917 ; 32 : 195-231.
Greenwald I, McGuire JB. The estimation of creatinine and of creatine in the blood. J Biol Chem 1918 ; 33 : 103-9.
Abderhalden E, Komm E. Uber die Anhydridstrukter der Proteine. Z Physiol Chem 1924 ; 139 : 181.
Hunter A. Creatine and creatinine. Monographs on biochemistry. London : Longmans, Green and Co. Ltd, 1928.
Miller BF, Dubos R. Studies on the presence of creatinine in human blood. J Biol Chem 1937 ; 121 : 447-56.
Cook JG. Factors influencing the assay of creatinine. Ann Clin Biochem 1975 ; 12 : 219-32.
Danielson IS. On the presence of creatinine in blood. J Biol Chem 1936 ; 113 : 181-95.
Perrone RD, Madias NE, Levey AS. Serum creatinine as an index of renal function : new insights into old concepts. Clin Chem 1992 ; 38 : 1933-53.
Bauer JH, Brooks CS, Burch RN. Clinical appraisal of creatinine clearance as a measurement of glomerular filtration rate. Am J Kidney Dis 1982 ; 2 : 337-46.
Gerard SK, Khayam-Bashi H. Characterization of creatinine error in ketotic patients. A prospective comparison of alkaline picrate methods with an enzymatic method. Am J Clin Pathol 1985 ; 84 : 659-64.
Haugen HN, Blegen EM. The true endogenous creatinine clearance. Scand J Clin Lab Invest 1953 ; 5 : 67-71.
Fabiny DL, Ertingshausen G. Automated reaction-rate method for determination of serum creatinine with the CentrifiChem. Clin Chem 1971 ; 17 : 696-700.
Lustgarten JA, Wenk RE. Simple, rapid, kinetic method for serum creatinine measurement. Clin Chem 1972 ; 18 : 1419-22.
Spencer K. Analytical reviews in clinical biochemistry : the estimation of creatinine. Ann Clin Biochem 1986 ; 23 (Pt 1) : 1-25.
Bowers LD, Wong ET. Kinetic serum creatinine assays. II. A critical evaluation and review. Clin Chem 1980 ; 26 : 555-61.
Mazzachi BC, Peake MJ, Ehrhardt V. Reference range and method comparison studies for enzymatic and Jaffe creatinine assays in plasma and serum and early morning urine. Clin Lab 2000 ; 46 : 53-5.
Parry DM. Use of single-value protein compensation of the Jaffe creatinine assay contributes to clinically significant inaccuracy in results. Clin Chem 2008 ; 54 : 215-6.
Ceriotti F, Boyd JC, Klein G, Henny J, Queralto J, Kairisto V, et al. M. Reference intervals for serum creatinine concentrations : assessment of available data for global application. Clin Chem 2008 ; 54 : 559-66.
Chan MH, Ng KF, Szeto CC, Lit LC, Chow KM, Leung CB, et al. CW. Effect of a compensated Jaffe creatinine method on the estimation of glomerular filtration rate. Ann Clin Biochem 2004 ; 41 : 482-4.
Wuyts B, Bernard D, Van den NN, Van de WJ, Van Vlem B, De Smet R, et al. Reevaluation of formulas for predicting creatinine clearance in adults and children, using compensated creatinine methods. Clin Chem 2003 ; 49 : 1011-4.
Miller BF, Dubos R. Determination by a specific enzymatic method of the creatinine content of blood and urine from normal and nephritic individuals. J Biol Chem 1937 ; 121 : 457-64.
Suzuki M. Purification and some properties of sarcosine oxidase from Corynebacterium sp. U-96. J Biochem 1981 ; 89 : 599-607.
Fossati P, Prencipe L, Berti G. Enzymic creatinine assay : a new colorimetric method based on hydrogen peroxide measurement. Clin Chem 1983 ; 29 : 1494-6.
Van Lente F, Suit P. Assessment of renal function by serum creatinine and creatinine clearance : glomerular filtration rate estimated by four procedures. Clin Chem 1989 ; 35 : 2326-30.
Fossati P, Ponti M, Passoni G, Tarenghi G. Melzi d'Eril GV, Prencipe L. A step forward in enzymatic measurement of creatinine. Clin Chem 1994 ; 40 : 130-7.
Junge W, Wilke B, Halabi A, Klein G. Determination of reference intervals for serum creatinine, creatinine excretion and creatinine clearance with an enzymatic and a modified Jaffe method. Clin Chim Acta 2004 ; 344 : 137-48.
Thienpont LM, Van Landuyt KG, Stockl D, De Leenheer AP. Candidate reference method for determining serum creatinine by isocratic HPLC : validation with isotope dilution gas chromatography-mass spectrometry and application for accuracy assessment of routine test kits. Clin Chem 1995 ; 41 : 995-1003.
Myers GL, Miller WG, Coresh J, Fleming J, Greenberg N, Greene T, et al. Recommendations for improving serum creatinine measurement : a report from the laboratory working group of the national kidney disease education program. Clin Chem 2006 ; 52 : 5-18.
Seronie-Vivien S, Galteau MM, Carlier MC, Hadj-Aissa A, Hanser AM, Hym B, et al. Impact of standardized calibration on the inter-assay variation of 14 automated assays for the measurement of creatinine in human serum. Clin Chem Lab Med 2005 ; 43 : 1227-33.
Delanaye P, Cavalier E, Chapelle JP, Krzesinski JM. Importance of the creatinine calibration in the estimation of GFR by MDRD equation. Nephrol Dial Transplant 2006 ; 21 : 1130.
Murthy K, Stevens LA, Stark PC, Levey AS. Variation in the serum creatinine assay calibration : a practical application to glomerular filtration rate estimation. Kidney Int 2005 ; 68 : 1884-7.
Bjorkhem I, Blomstrand R, Ohman G. Mass fragmentography of creatinine proposed as a reference method. Clin Chem 1977 ; 23 : 2114-21.
Seronie-Vivien S, Pieroni L, Galteau MM, Carlier MC, Hanser AM, Cristol JP. Evolution des modalités d'évaluation de la fonction rénale basée sur la créatinine entre 2005 et 2008 : conséquences pour les biologistes. Ann Biol Clin (Paris) 2008 ; 66 : 263-8.
Delanaye P, Cohen EP. Formula-based estimates of the GFR : equations variable and uncertain. Nephron Clin Pract 2008 ; 110 : c48-c53.
Heymsfield SB, Arteaga C, McManus C, Smith J, Moffitt S. Measurement of muscle mass in humans : validity of the 24-hour urinary creatinine method. Am J Clin Nutr 1983 ; 37 : 478-94.
Cocchetto DM, Tschanz C, Bjornsson TD. Decreased rate of creatinine production in patients with hepatic disease : implications for estimation of creatinine clearance. Ther Drug Monit 1983 ; 5 : 161-8.
Borsook H, Dubnoff JW. The hydrolysis of phosphocreatine and the origin of urinary creatinine. J Biol Chem 1947 ; 168 : 493-510.
Walser M. Assessing renal function from creatinine measurements in adults with chronic renal failure. Am J Kidney Dis 1998 ; 32 : 23-31.
Shaffer P. The excretion of kreatinine and kreatin in health and disease. Am J Physiol 1908 ; 23 : 1-22.
Horber FF, Scheidegger J, Frey FJ. Overestimation of renal function in glucocorticosteroid treated patients. Eur J Clin Pharmacol 1985 ; 28 : 537-41.
Kasiske BL. Creatinine excretion after renal transplantation. Transplantation 1989 ; 48 : 424-8.
Friedman RB, Anderson RE, Entine SM, Hirshberg SB. Effects of diseases on clinical laboratory tests. Clin Chem 1980 ; 26 : 1D-476D.
Mohler JL, Barton SD, Blouin RA, Cowen DL, Flanigan RC. The evaluation of creatinine clearance in spinal cord injury patients. J Urol 1986 ; 136 : 366-9.
Davies DF, Shock NW. Age changes in glomerular filtration rate, effective renal plasma flow, and tubular excretory capacity in adult males. J Clin Invest 1950 ; 29 : 496-507.
Schwartz GJ, Haycock GB, Spitzer A. Plasma creatinine and urea concentration in children : normal values for age and sex. J Pediatr 1976 ; 88 : 828-30.
Crim MC, Calloway DH, Margen S. Creatine metabolism in men : creatine pool size and turnover in relation to creatine intake. J Nutr 1976 ; 106 : 371-81.
Papadakis MA, Arieff AI. Unpredictability of clinical evaluation of renal function in cirrhosis. Prospective study. Am J Med 1987 ; 82 : 945-52.
Preiss DJ, Godber IM, Lamb EJ, Dalton RN, Gunn IR. The influence of a cooked-meat meal on estimated glomerular filtration rate. Ann Clin Biochem 2007 ; 44 : 35-42.
Mayersohn M, Conrad KA, Achari R. The influence of a cooked meat meal on creatinine plasma concentration and creatinine clearance. Br J Clin Pharmacol 1983 ; 15 : 227-30.
Dominguez R, Pomerene E. Recovery of creatinine after ingestion and after intravenous injection in man. Proc Soc Exp Biol Med 1945 ; 58 : 26-9.
Pline KA, Smith CL. The effect of creatine intake on renal function. Ann Pharmacother 2005 ; 39 : 1093-6.
Levey AS, Eckardt KU, Tsukamoto Y, Levin A, Coresh J, Rossert J, et al. Definition and classification of chronic kidney disease : a position statement from Kidney Disease : Improving Global Outcomes (KDIGO). Kidney Int 2005 ; 67 : 2089-100.
Shemesh O, Golbetz H, Kriss JP, Myers BD. Limitations of creatinine as a filtration marker in glomerulopathic patients. Kidney Int 1985 ; 28 : 830-8.
van Acker BA, Koomen GC, Koopman MG, de Waart DR, Arisz L. Creatinine clearance during cimetidine administration for measurement of glomerular filtration rate. Lancet 1992 ; 340 : 1326-9.
Bauer JH, Brooks CS, Burch RN. Renal function studies in man with advanced renal insufficiency. Am J Kidney Dis 1982 ; 2 : 30-5.
DeSanto NG, Coppola S, Anastasio P, Coscarella G, Capasso G, Bellini L, et al. Predicted creatinine clearance to assess glomerular filtration rate in chronic renal disease in humans. Am J Nephrol 1991 ; 11 : 181-5.
Berlyne GM, Varley H, Nilwarangkur S, Hoerni M. Endogenouscreatinine clearance and glomerular-filtration rate. Lancet 1964 ; 22 : 874-6.
Hilton PJ, Roth Z, Lavender S, Jones NF. Creatinine clearance in patients with proteinuria. Lancet 1969 ; 2 : 1215-6.
Hsu CY, Chertow GM, Curhan GC. Methodological issues in studying the epidemiology of mild to moderate chronic renal insufficiency. Kidney Int 2002 ; 61 : 1567-76.
van Acker BA, Koomen GC, Koopman MG, Krediet RT, Arisz L. Discrepancy between circadian rhythms of inulin and creatinine clearance. J Lab Clin Med 1992 ; 120 : 400-10.
McCance RA, Widdowson EM. Functional disorganization of the kidney in disease. J Physiol 1939 ; 95 : 36-44.
Levinsky NG, Berliner W. Changes in composition of the urine in ureter and bladder at low urine flow. Am J Physiol 1959 ; 196 : 549-53.
Miller BF, Leaf A, Mamby AR, Miller Z. Validity of the endogenous creatinine clearance as a measure of glomerular filtration rate in the diseased human kidney. J Clin Invest 1952 ; 31 : 309-13.
Crim MC, Calloway DH, Margen S. Creatine metabolism in men : urinary creatine and creatinine excretions with creatine feeding. J Nutr 1975 ; 105 : 428-38.
Mitch WE, Walser M. A proposed mechanism for reduced creatinine excretion in severe chronic renal failure. Nephron 1978 ; 21 : 248-54.
Mitch WE, Collier VU, Walser M. Creatinine metabolism in chronic renal failure. Clin Sci (Lond) 1980 ; 58 : 327-35.
Jones JD, Burnett PC. Implication of creatinine and gut flora in the uremic syndrome : induction of "creatininase" in colon contents of the rat by dietary creatinine. Clin Chem 1972 ; 18 : 280-4.
Couchoud C, Pozet N, Labeeuw M, Pouteil-Noble C. Screening early renal failure : cut-off values for serum creatinine as an indicator of renal impairment. Kidney Int 1999 ; 55 : 1878-84.
Brochner-Mortensen J, Jensen S, Rodbro P. Assessment of renal function from plasma creatinine in adult patients. Scand J Urol Nephrol 1977 ; 11 : 263-70.
Morgan DB, Dillon S, Payne RB. The assessment of glomerular function : creatinine clearance or plasma creatinine ? Postgrad Med J 1978 ; 54 : 302-10.
Waikar SS, Bonventre JV. Creatinine kinetics and the definition of acute kidney injury. J Am Soc Nephrol 2009 ; 20 : 672-9.
Watkins RE, Feldkamp CS, Thibert RJ, Zak B. Interesting interferences in a direct serum creatinine reaction. Microchem J 1976 ; 21 : 370-84.
Knapp ML, Hadid O. Investigations into negative interference by jaundiced plasma in kinetic Jaffe methods for plasma creatinine determination. Ann Clin Biochem 1987 ; 24 (Pt 1) : 85-97.
Boot S, LaRoche N, Legg EF. Elimination of bilirubin interference in creatinine assays by routine techniques : comparisons with a high performance liquid chromatography method. Ann Clin Biochem 1994 ; 31 (Pt 3) : 262-6.
Owen LJ, Keevil BG. Does bilirubin cause interference in Roche creatinine methods ? Clin Chem 2007 ; 53 : 370-1.
Lindback B, Bergman A. A new commercial method for the enzymatic determination of creatinine in serum and urine evaluated : comparison with a kinetic Jaffe method and isotope dilution-mass spectrometry. Clin Chem 1989 ; 35 : 835-7.
Toffaletti J, Blosser N, Hall T, Smith S, Tompkins D. An automated dry-slide enzymatic method evaluated for measurement of creatinine in serum. Clin Chem 1983 ; 29 : 684-7.
Cobbaert CM, Baadenhuijsen H, Weykamp CW. Prime time for enzymatic creatinine methods in pediatrics. Clin Chem 2009 ; 55 : 549-58.
Kroll MH, Elin RJ. Mechanism of cefoxitin and cephalothin interference with the Jaffe method for creatinine. Clin Chem 1983 ; 29 : 2044-8.
Daly TM, Kempe KC, Scott MG. "Bouncing" creatinine levels. N Engl J Med 1996 ; 334 : 1749-50.
Lognard M, Cavalier E, Chapelle JP, Lambermont B, Krzesinski JM, Delanaye P. Acetylcysteine and enzymatic creatinine : beware of laboratory artefact ! Intensive Care Med 2008 ; 34 : 973-4.
Bagnoud MA, Reymond JP. Interference of metamizol (dipyrone) on the determination of creatinine with the Kodak dry chemistry slide comparison with the enzymatic method from Boehringer. Eur J Clin Chem Clin Biochem 1993 ; 31 : 753-7.
Saenger AK, Lockwood C, Snozek CL, Milz TC, Karon BS, Scott MG, et al. Catecholamine interference in enzymatic creatinine assays. Clin Chem 2009 ; 55 : 1732-6.
Richards RK, Bjornsson TD, Waterbury LD. Rise in serum and urine creatinine after phenacemide. Clin Pharmacol Ther 1978 ; 23 : 430-7.
Larsson R, Bodemar G, Kagedal B. The effect of cimetidine, a new histamine H2-receptor antagonist, on renal function. Acta Med Scand 1979 ; 205 : 87-9.
van den Berg JG, Koopman MG, Arisz L. Ranitidine has no influence on tubular creatinine secretion. Nephron 1996 ; 74 : 705-8.
Berglund F, Killander J, Pompeius R. Effect of trimethoprimsulfamethoxazole on the renal excretion of creatinine in man. J Urol 1975 ; 114 : 802-8.
Trollfors B, Wahl M, Alestig K. Co-trimoxazole, creatinine and renal function. J Infect 1980 ; 2 : 221-6.
Berglund F. Urinary excretion patterns for substances with simultaneous secretion and reabsorption by active transport. Acta Physiol Scand 1961 ; 52 : 276-90.
Rudra T, Webb DB, Evans AG. Acute tubular necrosis following co-trimoxazole therapy. Nephron 1989 ; 53 : 85-6.
Devuyst O, Goffin E, Pirson Y, van Ypersele DS. Creatinine rise after fibrate therapy in renal graft recipients. Lancet 1993 ; 341 : 840.
Broeders N, Knoop C, Antoine M, Tielemans C, Abramowicz D. Fibrate-induced increase in blood urea and creatinine : is gemfibrozil the only innocuous agent ? Nephrol Dial Transplant 2000 ; 15 : 1993-9.
Hottelart C, el Esper N, Rose F, Achard JM, Fournier A. Fenofibrate increases creatininemia by increasing metabolic production of creatinine. Nephron 2002 ; 92 : 536-41.
Ansquer JC, Dalton RN, Causse E, Crimet D, Le Malicot K, Foucher C. Effect of fenofibrate on kidney function : a 6-week randomized crossover trial in healthy people. Am J Kidney Dis 2008 ; 51 : 904-13.
Bauer C, Melamed ML, Hostetter TH. Staging of chronic kidney disease : time for a course correction. J Am Soc Nephrol 2008 ; 19 : 844-6.
Greenblatt DJ, Ransil BJ, Harmatz JS, Smith TW, Duhme DW, Koch-Weser J. Variability of 24-hour urinary creatinine excretion by normal subjects. J Clin Pharmacol 1976 ; 16 : 321-8.
Ransil BJ, Greenblatt DJ, Koch-Weser J. Evidence for systematic temporal variation in 24-hour urinary creatinine excretion. J Clin Pharmacol 1977 ; 17 : 108-19.
Brochner-Mortensen J, Rodbro P. Selection of routine method for determination of glomerular filtration rate in adult patients. Scand J Clin Lab Invest 1976 ; 36 : 35-43.
Toto RD, Kirk KA, Coresh J, Jones C, Appel L, Wright J, et al. Evaluation of serum creatinine for estimating glomerular filtration rate in African Americans with hypertensive nephrosclerosis : results from the African-American Study of Kidney Disease and Hypertension (AASK) Pilot Study. J Am Soc Nephrol 1997 ; 8 : 279-87.
National Kidney Foundation. K/DOQI clinical practice guidelines for chronic kidney disease : evaluation, classification, and stratification. Am J Kidney Dis 2002 ; 39 : S1-266.
Hilbrands LB, Artz MA, Wetzels JF, Koene RA. Cimetidine improves the reliability of creatinine as a marker of glomerular filtration. Kidney Int 1991 ; 40 : 1171-6.
Lubowitz H, Slatopolsky E, Shankel S, Rieselbach RE, Bricker NS. Glomerular filtration rate. Determination in patients with chronic renal disease. JAMA 1967 ; 199 : 252-6.
Lavender S, Hilton PJ, Jones NF. The measurement of glomerular filtration-rate in renal disease. Lancet 1969 ; 2 : 1216-8.
Levey AS, Bosch JP, Lewis JB, Greene T, Rogers N, Roth D. A more accurate method to estimate glomerular filtration rate from serum creatinine : a new prediction equation. Modification of Diet in Renal Disease Study Group. Ann Intern Med 1999 ; 130 : 461-70.