Both the hippocampus and striatum are involved in consolidation of motor sequence memory.

Adult; Analysis of Variance; Brain Mapping; Corpus Striatum/blood supply/physiology; Eye Movements/physiology/radiation effects; Female; Hippocampus/blood supply/physiology; Humans; Image Processing, Computer-Assisted/methods; Magnetic Resonance Imaging; Male; Memory/physiology; Oxygen/blood; Reaction Time/physiology; Serial Learning/physiology; Task Performance and Analysis

Abstract :

[en] Functional magnetic resonance imaging (fMRI) was used to investigate the cerebral correlates of motor sequence memory consolidation. Participants were scanned while training on an implicit oculomotor sequence learning task and during a single testing session taking place 30 min, 5 hr, or 24 hr later. During training, responses observed in hippocampus and striatum were linearly related to the gain in performance observed overnight, but not over the day. Responses in both structures were significantly larger at 24 hr than at 30 min or 5 hr. Additionally, the competitive interaction observed between these structures during training became cooperative overnight. These results stress the importance of both hippocampus and striatum in procedural memory consolidation. Responses in these areas during training seem to condition the overnight memory processing that is associated with a change in their functional interactions. These results show that both structures interact during motor sequence consolidation to optimize subsequent behavior.

Disciplines :

Neurology

Author, co-author :

Albouy, Geneviève ; Université de Liège - ULiège > Centre de recherches du cyclotron

Sterpenich, Virginie ; Université de Liège - ULiège > Centre de recherches du cyclotron

Balteau, Evelyne ; Université de Liège - ULiège > Centre de recherches du cyclotron

Vandewalle, Gilles ; Université de Liège - ULiège > Centre de recherches du cyclotron

Desseilles, Martin ; Université de Liège - ULiège > Département des sciences cliniques > Psychiatrie et psychologie médicale

Dang Vu, Thien Thanh ; Université de Liège - ULiège > Département des sciences cliniques > Neurologie

Darsaud, Annabelle

Ruby, Perrine

Luppi, Pierre-Herve

Degueldre, Christian ; Université de Liège - ULiège > Centre de recherches du cyclotron

More authors (3 more)

Language :

English

Title :

Both the hippocampus and striatum are involved in consolidation of motor sequence memory.

Publication date :

2008

Journal title :

Neuron

ISSN :

0896-6273

eISSN :

1097-4199

Publisher :

Cell Press, Cambridge, United Kingdom

Volume :

Issue :

Pages :

261-72

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 02 March 2009

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Scopus citations^®

333

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291

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311

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