[en] Background: Infectious diseases are significant causes of morbidity and mortality among elderly
populations. However, the relationship between oxidative stress, immune function and
inflammatory response in acute phase of the infectious disease is poorly understood.
Results: Herein the abundance of a selection of 148 transcripts involved in immunosenescence
and stress response was compared in total RNA of PBMC of 28 healthy aged probands and 39
aged patients in acute phase of infectious disease (day 2-4 after hospitalization) or in
convalescence phase (day 7-10). This study provides a list of 24 differentially abundant transcript
species in the acute phase versus healthy aged. For instance, transcripts associated with
inflammatory and anti-inflammatory reactions (TNFRSF1A, IL1R1, IL1R2, IL10RB) and with
oxidative stress (HMOX1, GPX1, SOD2, PRDX6) were more abundant while those associated
with T-cell functions (CD28, CD69, LCK) were less abundant in acute phase. The abundance of
seven of these transcripts (CD28, CD69, LCK, CTSD, HMOX1, TNFRSF1A and PRDX6) was
already known to be altered in healthy aged probands compared to healthy young ones and was
further affected in aged patients in acute phase, compromising an efficient response.
Conclusion: This work provides insights of the state of acute phase response to infections in
elderly patients and could explain further the lack of appropriate response in the elderly compared
to younger persons.
Disciplines :
Geriatrics Immunology & infectious disease
Author, co-author :
Duy Vo, Thi Kim; Facultés Universitaires Notre-Dame de la Paix - Namur - FUNDP > Research Institute for Life Sciences > Research Unit on Cellular Biology
Godard, Patrice; Facultés Universitaires Notre-Dame de la Paix - Namur - FUNDP > Research Institute for Life Sciences
de Saint-Hubert, Marie; Université Catholique de Louvain - UCL > University Hospital of Mont-Godinne > Geriatrics
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