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Le sepsis, réponse adaptée ou non à l’infection?

Damas, Pierre

2009 • In Réanimation, 18 (4), p. 277-281

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https://hdl.handle.net/2268/72649

DOI
10.1016/j.reaurg.2009.03.001

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Keywords :

Sepsis; Inflammation; Choc septique; Facteurs de virulence

Abstract :

[en] Sepsis, severe sepsis and septic shock were thought to be provoked by an overwhelming inflammation in response to an infectious process. This was documented in several animal studies. However, in human sepsis, excess of inflammation is hard to be observed. Compartimentalization of the host response rather favors a systemic anti-inflammatory climate. Clinical situations are complex: on one hand, virulence factors of microorganisms can directly harm the host tissues, divert the defence mechanisms or distract the control mechanisms of the host, preventing the normal interaction of endogenous mediators. On the other hand, septic shock mostly occurs in patients experiencing previous organic or functional vital failures before the development of infection. The vulnerability of the patient appears therefore to be a key point in the severity of the disease. Enhancing the host defence mechanisms rather than inhibiting the inflammatory reaction may become a preferential option.

Disciplines :

Anesthesia & intensive care

Author, co-author :

Damas, Pierre ; Université de Liège - ULiège > Soins intensifs

Language :

French

Title :

Le sepsis, réponse adaptée ou non à l’infection?

Alternative titles :

[en] Sepsis, adaptive or maladaptive response to infection?

Publication date :

2009

Journal title :

Réanimation

ISSN :

1624-0693

eISSN :

1951-6959

Publisher :

Elsevier, Netherlands

Volume :

18

Issue :

4

Pages :

277-281

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 22 September 2010

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