Physiologically Based Pharmacokinetic (PBPK) Models for Lifetime Exposure to PCB 153 in Male and Female Harbor Porpoises (Phocoena phocoena): Model Development and Evaluation
Phocoena phocoena; Physiologically based pharmacokinetic models; pollutants; PCB 153
Abstract :
[en] Physiologically based pharmacokinetic (PBPK) models were
developed for the most persistent polychlorinated biphenyl (PCB
153) in male and female harbor porpoises (Phocoena
phocoena) to elucidate processes such as uptake, distribution,
and elimination. Due to its limited metabolic capacities, long
life span, and top position in marine food chains, this species
is highly sensitive to pollution. The models consist of 5
compartments, liver, blubber, kidney, brain, and a compartment
which accounts for the rest of the body, all connected
through blood. All physiological and biochemical parameters
were extracted from the literature, except for the brain/blood
partition coefficient and rate of excretion, which were both fitted
to data sets used for validation of the models. These data
sets were compiled from our own analyses performed with GCMS
on tissue samples of harbor porpoises. The intake of
PCB 153 was from milk from birth to 4 months, and after weaning
fish was the main food source. Overall, these models reveal
that concentrations of PCB 153 in males increase with age but
suggest that,asthe animalsgrowolder, metabolic transformation
can be a possible pathway for elimination as well. In contrast,
the model for females confirms that gestation and lactation are
key processes for eliminating PCB 153 as body burdens
decrease with age. These PBPK models are capable of
simulating the bioaccumulation of PCB 153 during the entire
life span of approximately 20 years of the harbor porpoises.
Weijs, Liesbeth; Toxicological Centre, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium
Yang, Raymond; Quantitative and Computational Toxicology Group, Department of Environmental and Radiological Health Sciences, Colorado
Covaci, Adrian; Toxicological Centre, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium
Das, Krishna ; Université de Liège - ULiège > Département des sciences et gestion de l'environnement > Océanologie
Blust, Ronny; Toxicological Centre, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium
Language :
English
Title :
Physiologically Based Pharmacokinetic (PBPK) Models for Lifetime Exposure to PCB 153 in Male and Female Harbor Porpoises (Phocoena phocoena): Model Development and Evaluation
Publication date :
2010
Journal title :
Environmental Science and Technology
ISSN :
0013-936X
eISSN :
1520-5851
Publisher :
American Chemical Society, Washington, United States - District of Columbia
Volume :
44
Pages :
7023–7030
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
FWO - Fonds Wetenschappelijk Onderzoek Vlaanderen F.R.S.-FNRS - Fonds de la Recherche Scientifique
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