Abstract :
[en] In the presence of a clinical acute monoarthritis, a differential diagnosis has
to be made between septic arthritis, gout and diffuse chondrocalcinosis. Gout
comes from a purine nucleotide metabolism disorder leading to serum urate level
elevation. This hyperuricemia can lead to the deposition of monosodium urate
crystals in the joints, causing acute attacks. After long-term evolution, others
tissues as the kidneys can be involved: it is chronic gout. The definite
diagnosis is based on the presence of monosodium urate crystals in the joint
fluid. The diagnosis of gout should prompt a search for associated medical
conditions that may affect both urate levels and longevity. These include
alcoholism, various nephropathies, myeloproliferative disorders, and
hypertension.
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