Increased matrix metalloproteinase-3 serum levels in rheumatic diseases: relationship with synovitis and steroid treatment

Ribbens, Clio; Martin y Porras, M.; Franchimont, N.; Kaiser, Marie-Joëlle; Jaspar, J. M.; Damas, Pierre; Houssiau, F. A.; Malaise, Michel

doi:10.1136/ard.61.2.161

Article (Scientific journals)

Increased matrix metalloproteinase-3 serum levels in rheumatic diseases: relationship with synovitis and steroid treatment

Ribbens, Clio; Martin y Porras, M.; Franchimont, N. et al.

2002 • In Annals of the Rheumatic Diseases, 61 (2), p. 161-166

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https://hdl.handle.net/2268/72419

DOI
10.1136/ard.61.2.161

PubMed
11796404

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Keywords :

Biological Markers; Glucocorticoids; Prednisolone; C-Reactive Protein; Matrix Metalloproteinase 3

Abstract :

[en] OBJECTIVE: To determine matrix metalloproteinase-3 (MMP-3) serum levels in patients with rheumatic diseases and to study the relation between MMP-3 and C reactive protein (CRP) levels. METHODS: MMP-3 serum levels were determined by enzyme linked immunosorbent assay (ELISA) in (a) patients with active inflammatory rheumatic diseases: rheumatoid arthritis (RA), psoriatic arthritis, polymyalgia rheumatica, acute crystal arthritis, and ankylosing spondylitis; (b) patients with active inflammatory systemic diseases: cutaneo-articular or renal systemic lupus erythematosus (SLE), systemic sclerosis, and vasculitides; (c) patients with non-inflammatory rheumatic diseases: osteoarthritis and fibromyalgia; (d) critically ill patients without rheumatic diseases, representing an acute inflammatory control group; (e) healthy controls. RESULTS: MMP-3 serum levels were significantly increased in patients with active RA, psoriatic arthritis, and polymyalgia rheumatica, whether treated or not by corticosteroids, and in female patients with acute crystal arthritis. MMP-3 serum levels were normal in steroid-free patients with active cutaneo-articular or renal SLE, systemic sclerosis, and vasculitides but were significantly increased in steroid treated patients. MMP-3 levels were normal in fibromyalgia, osteoarthritis, ankylosing spondylitis, and acute inflammatory controls. MMP-3 was significantly correlated with CRP in RA (r=0.5, p=0.0004) but not in any of the other disease groups. CONCLUSIONS: MMP-3 serum levels are increased in inflammatory rheumatic diseases characterised by joint synovitis, such as RA, polymyalgia rheumatica, psoriatic arthritis, and acute crystal arthritis-that is, whether the diseases are acute or chronic, erosive or not. They are normal in SLE, systemic sclerosis, and vasculitides as well as in non-rheumatic inflammatory controls, but are significantly increased by steroids. These data strongly suggest that serum MMP-3 reflects synovial inflammation.

Disciplines :

Rheumatology

Author, co-author :

Ribbens, Clio ; Université de Liège - ULiège > Rhumatologie

Martin y Porras, M.

Franchimont, N.

Kaiser, Marie-Joëlle ; Université de Liège - ULiège > Rhumatologie

Jaspar, J. M.

Damas, Pierre ; Université de Liège - ULiège > Soins intensifs

Houssiau, F. A.

Malaise, Michel ; Université de Liège - ULiège > Département des sciences cliniques > Rhumatologie

Language :

English

Title :

Increased matrix metalloproteinase-3 serum levels in rheumatic diseases: relationship with synovitis and steroid treatment

Publication date :

2002

Journal title :

Annals of the Rheumatic Diseases

ISSN :

0003-4967

eISSN :

1468-2060

Publisher :

BMJ Group, London, United Kingdom

Volume :

Issue :

Pages :

161-166

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 19 September 2010

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