Retrograde reactions of Clarke's nucleus neurons after human spinal cord injury

[en] Successful axon regeneration depends on the expression of regeneration-associated genes by axotomized neurons. Here, we demonstrate, for the first time to our knowledge, the expression of regeneration-associated genes by axotomized human CNS neurons. In situ hybridization and immunohistochemistry showed a transient induction of GAP-43 and c-jun in Clarke's nucleus neurons caudal to traumatic human spinal cord injury. These results support experimental data that nonregenerating central nervous system neurons can temporarily upregulate regeneration-associated genes, reflecting a transient regenerative capacity that fails over time.

Disciplines :

Neurology
Neurosciences & behavior
Surgery

Author, co-author :

Schmitt, Andreas B.

Breuer, Sebastien

Polat, Leyla

Pech, Katrin

Kakulas, Byran

Love, Seth

Martin, Didier ; Université de Liège - ULiège > Département des sciences cliniques > Neurochirurgie

Schoenen, Jean ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Neuro-anatomie

Noth, Johannes

Brook, Gary A.

Language :

English

Title :

Retrograde reactions of Clarke's nucleus neurons after human spinal cord injury

Publication date :

October 2003

Journal title :

Annals of Neurology

ISSN :

0364-5134

eISSN :

1531-8249

Publisher :

Wiley Liss, Inc., New York, United States - New York

Volume :

Issue :

Pages :

534-539

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 27 February 2009

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Bibliography

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