Article (Scientific journals)
Retrograde reactions of Clarke's nucleus neurons after human spinal cord injury
Schmitt, Andreas B.; Breuer, Sebastien; Polat, Leyla et al.
2003In Annals of Neurology, 54 (4), p. 534-539
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Abstract :
[en] Successful axon regeneration depends on the expression of regeneration-associated genes by axotomized neurons. Here, we demonstrate, for the first time to our knowledge, the expression of regeneration-associated genes by axotomized human CNS neurons. In situ hybridization and immunohistochemistry showed a transient induction of GAP-43 and c-jun in Clarke's nucleus neurons caudal to traumatic human spinal cord injury. These results support experimental data that nonregenerating central nervous system neurons can temporarily upregulate regeneration-associated genes, reflecting a transient regenerative capacity that fails over time.
Disciplines :
Neurology
Neurosciences & behavior
Surgery
Author, co-author :
Schmitt, Andreas B.
Breuer, Sebastien
Polat, Leyla
Pech, Katrin
Kakulas, Byran
Love, Seth
Martin, Didier  ;  Université de Liège - ULiège > Département des sciences cliniques > Neurochirurgie
Schoenen, Jean  ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Neuro-anatomie
Noth, Johannes
Brook, Gary A.
Language :
English
Title :
Retrograde reactions of Clarke's nucleus neurons after human spinal cord injury
Publication date :
October 2003
Journal title :
Annals of Neurology
ISSN :
0364-5134
eISSN :
1531-8249
Publisher :
Wiley Liss, Inc., New York, United States - New York
Volume :
54
Issue :
4
Pages :
534-539
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 27 February 2009

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