Nt-3 Has a Tropic Effect on Process Outgrowth by Postnatal Auditory Neurones in Vitro

[en] CONFOCAL analysis of early postnatal auditory neurones in a bicompartmental culture system was used to test for chemoattractant properties of NGF, BDNF and NT-3 on neuronal process outgrowth. NT-3 exerted a strong tropic effect on neuritic outgrowth from auditory neurones in this system. BDNF and NGF did not have any tropic activity that directed processes outgrowth from auditory neurones. However, BDNF was important for the support of neuronal survival in NGF-treated cultures and for neuritogenesis in NT-3-treated cultures. Since NT-3 has been identified as both a survival factor and a chemotropic agent for auditory neurones, it is likely that this neurotrophin will be a useful therapeutic agent in the treatment of damaged cochleae for the recovery of hearing.

Disciplines :

Surgery

Author, co-author :

Malgrange, Brigitte ; Université de Liège - ULiège > CNCM/ Centre fac. de rech. en neurobiologie cell. et moléc.

LEFEBVRE, Philippe

Martin, Didier ; Université de Liège - ULiège > Département des sciences cliniques > Neurochirurgie

Staecker, H.

Van de Water, T. R.

Moonen, Gustave ; Université de Liège - ULiège > Département des sciences cliniques > Neurologie - Doyen de la Faculté de Médecine

Language :

English

Title :

Nt-3 Has a Tropic Effect on Process Outgrowth by Postnatal Auditory Neurones in Vitro

Publication date :

04 November 1996

Journal title :

Neuroreport

ISSN :

0959-4965

eISSN :

1473-558X

Publisher :

Lippincott Williams & Wilkins, United States

Volume :

Issue :

15-17

Pages :

2495-9

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 27 February 2009

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