Article (Scientific journals)
Nt-3 Has a Tropic Effect on Process Outgrowth by Postnatal Auditory Neurones in Vitro
Malgrange, Brigitte; LEFEBVRE, Philippe; Martin, Didier et al.
1996In Neuroreport, 7 (15-17), p. 2495-9
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Abstract :
[en] CONFOCAL analysis of early postnatal auditory neurones in a bicompartmental culture system was used to test for chemoattractant properties of NGF, BDNF and NT-3 on neuronal process outgrowth. NT-3 exerted a strong tropic effect on neuritic outgrowth from auditory neurones in this system. BDNF and NGF did not have any tropic activity that directed processes outgrowth from auditory neurones. However, BDNF was important for the support of neuronal survival in NGF-treated cultures and for neuritogenesis in NT-3-treated cultures. Since NT-3 has been identified as both a survival factor and a chemotropic agent for auditory neurones, it is likely that this neurotrophin will be a useful therapeutic agent in the treatment of damaged cochleae for the recovery of hearing.
Disciplines :
Surgery
Author, co-author :
Malgrange, Brigitte  ;  Université de Liège - ULiège > CNCM/ Centre fac. de rech. en neurobiologie cell. et moléc.
LEFEBVRE, Philippe 
Martin, Didier  ;  Université de Liège - ULiège > Département des sciences cliniques > Neurochirurgie
Staecker, H.
Van de Water, T. R.
Moonen, Gustave  ;  Université de Liège - ULiège > Département des sciences cliniques > Neurologie - Doyen de la Faculté de Médecine
Language :
English
Title :
Nt-3 Has a Tropic Effect on Process Outgrowth by Postnatal Auditory Neurones in Vitro
Publication date :
04 November 1996
Journal title :
Neuroreport
ISSN :
0959-4965
eISSN :
1473-558X
Publisher :
Lippincott Williams & Wilkins, United States
Volume :
7
Issue :
15-17
Pages :
2495-9
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 27 February 2009

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