Article (Scientific journals)
Etanercept in Therapy Multiresistant Pityriasis Lichenoides, overlapping type
Nikkels, Arjen; Gillard, Patricia; Pierard, Gérald
2008In Journal of Drugs in Dermatology
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Keywords :
pityriasis lichenoides; Overlapping pityriasis lichenoides; OPL; etanercept
Abstract :
[en] Introduction : Pityriasis licehnoides (PL) exhibits a protean clinical presentation, particularly in its overlapping form (OPL) combining aspects of the acute and chronic types. Some patients are drug multiresistant and pose a therapeutic dilemma. The anti-tumor necrosis factor (TNF)-α agent etanercept, was recently introduced as an alternative treatment for psoriasis, rheumatoid arthritis, and psoriatic arthritis. Case Report: A 65-year-old woman suffered from an overlapping form of pityriasis lichenoides (OPL) for 5 years. Several initial acute episodes were controlled by successive courses of oral antibiotics, topical corticosteroids, and/or psoralen ultraviolet light-A (PUVA) therapy. The disease progressively evolved to a more chronic form. Topical immune response modifiers and corticosteroïds, as well as PUVA, ultraviolet light B (UVB), methorexate, dapsone, and cyclosporine were introduces, but all proved ineffective. Due to the therapy multiresistance, 2 weekly injections of etanercept were administered. After 2 months, a marked improvement was observed in regards to the patient’s pruritus and inflammation. No treatment-related adverse effects were observed. Therapy was continued for 4 months without any new lesion development. However, 1 month after stopping treatment new OPL lesions recurred. Conclusion : At the time of publication, this is the first report of the effectiveness of etanercept in OPL. This drug might be considered as a therapeutic alternative for treatment multiresistant OPL.
Disciplines :
Dermatology
Author, co-author :
Nikkels, Arjen ;  Centre Hospitalier Universitaire de Liège - CHU > Dermatologie
Gillard, Patricia ;  Centre Hospitalier Universitaire de Liège - CHU > Dermatologie
Pierard, Gérald ;  Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie
Language :
English
Title :
Etanercept in Therapy Multiresistant Pityriasis Lichenoides, overlapping type
Publication date :
October 2008
Journal title :
Journal of Drugs in Dermatology
ISSN :
1545-9616
Publisher :
Journal of Drugs in Dermatology, United States
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 27 February 2009

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