Real-life practice study of the clinical outcome and cost-effectiveness of photodynamic therapy using methyl aminolevulinate (MAL-PDT) in the management of actinic keratosis and basal cell carcinoma
[en] Photodynamic therapy with methyl aminolevulinate (MAL-PDT) is a non-invasive therapy for superficial and nodular basal cell carcinoma (BCC). We performed an open-label trial to evaluate efficacy, safety, tolerability and cosmetic outcome of MAL-PDT in selected patients with superficial and nodular BCCs. Ninety-four superficial and 24 nodular BCCs in 69 patients were treated with 2 to 8 MAL-PDT sessions. Efficacy, safety, tolerability and cosmetic outcome were evaluated at months 1, 3, 6 and 12 after the last MAL-PDT treatment and then every 3 months. One patient discontinued the study for reasons unrelated to study procedures. Complete clinical regression was detected in 84/94 (89.4%) superficial BCCs, and 12/23 (52.2%) nodular BCCs one month after 2 MAL-PDT sessions. No further clinical improvement was observed in either superficial or nodular BCCs with treatment continuation up to a maximum of 8 MAL-PDT sessions. Adverse effects were limited to mild local skin reactions, and cosmetic outcome was rated as excellent or good. Recurrence was observed in 2/84 (2.4%) successfully treated superficial BCCs at 6 and 12 months after treatment discontinuation. Based on the efficacy, tolerability, cosmetic outcome and recurrence rate, our results support the use of MAL-PDT for treatment of superficial BCC and for selected cases of nodular BCC.
Disciplines :
Dermatology
Author, co-author :
Annemans, Lieven; Universitair Ziekenhuis Gent - UZ
Caekelbergh, Karin; IMS Health, Brussels
Roelandts, Rik; Universitair Ziekenhuis Leuven
Boonen, Hugo; H. Hart, Mol
Leys, Christophe ; Centre Hospitalier Universitaire de Liège - CHU > Dermatologie
Nikkels, Arjen ; Centre Hospitalier Universitaire de Liège - CHU > Dermatologie
van Den Haute, V.; Clinique 2 Alice, Uccle
van Quickenborne, L.; A.Z. Sint-Lucas Ghent
Verhaeghe, Evelien; Universitair Ziekenhuis Gent - UZ
Real-life practice study of the clinical outcome and cost-effectiveness of photodynamic therapy using methyl aminolevulinate (MAL-PDT) in the management of actinic keratosis and basal cell carcinoma
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