Article (Scientific journals)
Neuroendocrine disruption of pubertal timing and interactions between homeostasis
Bourguignon, Jean-Pierre; Rasier, Gregory; Lebrethon, Marie-Christine et al.
2010In Molecular and Cellular Endocrinology, 324 (1-2), p. 110-120
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Keywords :
hypothalamus; puberty; gonadotropin-releasing hormone; endocrine disrupters; energy balance; nutrition
Abstract :
[en] The involvement of environmental factors such as endocrine disrupting chemicals (EDCs) in the timing of onset of puberty is suggested by recent changes in age at onset of puberty and pattern of distribution that are variable among countries, as well as new forms of sexual precocity after migration. However, the evidence of association between early or late pubertal timing and exposure to EDCs is weak in humans, possibly due to heterogeneity of effects likely involving mixtures and incapacity to assess fetal or neonatal exposure retrospectively. The neuroendocrine system which is crucial for physiological onset of puberty is targeted by EDCs. These compounds also act directly in the gonads and peripheral sex-steroid sensitive tissues. Feedbacks add to the complexity of regulation so that changes in pubertal timing caused by EDCs can involve both central and peripheral mechanisms. In experimental conditions, several neuroendocrine endpoints are affected by EDCs though only few studies including from our laboratory aimed at EDC involvement in the pathophysiology of early sexual maturation. Recent observations support the concept that EDC cause disturbed energy balance and account for the obesity epidemic. Several aspects are linking this system and the reproductive axis: coexisting neuroendocrine and peripheral effects, dependency on fetal/neonatal programming and the many factors cross-linking the two systems, for instance leptin, adiponectin, Agouti Related Peptide (AgRP). This opens perspectives for future research and, hopefully, measures preventing the disturbances of homeostasis caused by EDCs.
Research center :
Giga-Neurosciences - ULiège
Disciplines :
Endocrinology, metabolism & nutrition
Author, co-author :
Bourguignon, Jean-Pierre ;  Université de Liège - ULiège > Département des sciences cliniques > Pédiatrie - IFRES
Rasier, Gregory ;  Université de Liège - ULiège > Département des sciences cliniques > Pédiatrie
Lebrethon, Marie-Christine ;  Université de Liège - ULiège > Pédiatrie
Gerard, Arlette ;  Université de Liège - ULiège > Pédiatrie
Naveau, Elise ;  Université de Liège - ULiège > Département des sciences cliniques > Pédiatrie
Parent, Anne-Simone ;  Université de Liège - ULiège > Département des sciences cliniques > Pédiatrie
Language :
English
Title :
Neuroendocrine disruption of pubertal timing and interactions between homeostasis
Publication date :
05 August 2010
Journal title :
Molecular and Cellular Endocrinology
ISSN :
0303-7207
eISSN :
1872-8057
Publisher :
North Holland Publishing Company, Amsterdam, Netherlands
Volume :
324
Issue :
1-2
Pages :
110-120
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
DG RDT - Commission Européenne. Direction Générale de la Recherche et de l'Innovation [BE]
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
Faculty of medicine at the university of Liège
BSGPE - Belgian Study Group for Pediatric Endocrinology [BE]
Available on ORBi :
since 27 August 2010

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