Reference : The alpha-fetoprotein knock-out mouse model suggests that parental behavior is sexual...
Scientific journals : Article
Human health sciences : Neurology
Human health sciences : Endocrinology, metabolism & nutrition
The alpha-fetoprotein knock-out mouse model suggests that parental behavior is sexually differentiated under the influence of prenatal estradiol.
Keller, Matthieu [INRA > UMR85 Physiologie de la Reproduction et des Comportements >]
Pawluski, Jodi mailto [Maastricht University (The Netherlands) > Faculty of Health, Medicine and Life Science > Department of Psychiatry and Neuropsychology >]
Brock, Olivier mailto [Université de Liège - ULiège > > > Doct. sc. (biol. orga. & écol. - Bologne)]
Douhard, Quentin [Université de Liège - ULiège > > Génétique >]
Bakker, Julie [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie de la différenciation sexuelle du cerveau >]
Hormones and Behavior
Academic Press
Yes (verified by ORBi)
San Diego
[en] hormones ; brain ; behavior
[en] In rodent species, sexual differentiation of the brain for many reproductive processes depends largely on estradiol. This was recently confirmed again by using the α-fetoprotein knockout (AFP-KO) mouse model, which lacks the protective actions of α-fetoprotein against maternal estradiol and as a result represents a good model to determine the contribution of prenatal estradiol to the sexual differentiation of the brain and behavior. In the present study, we determined whether parental responses are differentiated prenatally under the influence of estradiol. It was found that AFP-KO females showed longer latencies to retrieve pups to the nest and also exhibited lower levels of crouching over the pups in the nest in comparison to WT females. Thus our results suggest that prenatal estradiol defeminizes the parental brain in mice.
Researchers ; Students

File(s) associated to this reference

Fulltext file(s):

Open access
KellerHB2010.pdfPublisher postprint430.43 kBView/Open

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.