The alpha-fetoprotein knock-out mouse model suggests that parental behavior is sexually differentiated under the influence of prenatal estradiol.

Keller, Matthieu; Pawluski, Jodi; Brock, Olivier; Douhard, Quentin; Bakker, Julie

doi:10.1016/j.yhbeh.2010.01.013

Article (Scientific journals)

The alpha-fetoprotein knock-out mouse model suggests that parental behavior is sexually differentiated under the influence of prenatal estradiol.

Keller, Matthieu; Pawluski, Jodi; Brock, Olivier et al.

2010 • In Hormones and Behavior

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/70007

DOI
10.1016/j.yhbeh.2010.01.013

PubMed
20109458

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Keywords :

hormones; brain; behavior

Abstract :

[en] In rodent species, sexual differentiation of the brain for many reproductive processes depends largely on estradiol. This was recently confirmed again by using the α-fetoprotein knockout (AFP-KO) mouse model, which lacks the protective actions of α-fetoprotein against maternal estradiol and as a result represents a good model to determine the contribution of prenatal estradiol to the sexual differentiation of the brain and behavior. In the present study, we determined whether parental responses are differentiated prenatally under the influence of estradiol. It was found that AFP-KO females showed longer latencies to retrieve pups to the nest and also exhibited lower levels of crouching over the pups in the nest in comparison to WT females. Thus our results suggest that prenatal estradiol defeminizes the parental brain in mice.

Research center :

Giga-Neurosciences - ULiège

Disciplines :

Neurology
Endocrinology, metabolism & nutrition

Author, co-author :

Keller, Matthieu; INRA > UMR85 Physiologie de la Reproduction et des Comportements

Pawluski, Jodi ; Maastricht University (The Netherlands) > Faculty of Health, Medicine and Life Science > Department of Psychiatry and Neuropsychology

Brock, Olivier ; Université de Liège - ULiège > Doct. sc. (biol. orga. & écol. - Bologne)

Douhard, Quentin ; Université de Liège - ULiège > Génétique

Bakker, Julie ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie de la différenciation sexuelle du cerveau

Language :

English

Title :

The alpha-fetoprotein knock-out mouse model suggests that parental behavior is sexually differentiated under the influence of prenatal estradiol.

Publication date :

2010

Journal title :

Hormones and Behavior

ISSN :

0018-506X

eISSN :

1095-6867

Publisher :

Academic Press, San Diego, United States - California

Peer reviewed :

Peer Reviewed verified by ORBi

Funders :

NICHD - National Institutes of Health. Eunice Kennedy Shriver National Institute of Child Health and Human Development [US-MD] [US-MD]

Available on ORBi :

since 23 August 2010

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