Mechanisms of Interaction of Endocrine-Disrupting Chemicals with Glutamate-Evoked Secretion of Gonadotropin-Releasing Hormone

Rasier, Gregory; Parent, Anne-Simone; Gerard, Arlette; Denooz, Raphael; Lebrethon, Marie-Christine; Charlier, Corinne; Bourguignon, Jean-Pierre

doi:10.1093/toxsci/kfm285

Article (Scientific journals)

Mechanisms of Interaction of Endocrine-Disrupting Chemicals with Glutamate-Evoked Secretion of Gonadotropin-Releasing Hormone

Rasier, Gregory; Parent, Anne-Simone; Gerard, Arlette et al.

2008 • In Toxicological Sciences, 102 (1), p. 33-41

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/69894

DOI
10.1093/toxsci/kfm285

PubMed
18032409

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Abstract :

[en] In previous studies, we detected a dichlorodiphenyltrichloroethane (DDT) derivative in the serum of children with sexual precocity after migration from developing countries. Recently, we reported that DDT stimulated pulsatile gonadotropin-releasing hormone (GnRH) secretion and sexual maturation in the female rat. The aim of this study was to delineate the mechanisms of interaction of endocrine-disrupting chemicals including DDT with GnRH secretion evoked by glutamate in vitro. Using hypothalamic explants obtained from 15-day-old female rats, estradiol (E2) and DDT caused a concentration-related increase in glutamate-evoked GnRH release while p,p'-dichlorodiphenyldichloroethene and methoxychlor had no effect. The effective DDT concentrations in vitro were consistent with the serum concentrations measured in vivo 5 days after exposure of immature rats to 10 mg/kg/day of o,p'-DDT. Bisphenol A induced some stimulatory effect, whereas no change was observed with 4-nonylphenol. The o,p'-DDT effects in vitro were prevented partially by a selective antagonist of the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) subtype of glutamate receptors. A complete prevention of o,p'-DDT effects was caused by an estrogen receptor (ER) antagonist as well as an aryl hydrocarbon receptor (AHR) antagonist and inhibitors of protein kinases A and C and mitogen-activated kinases. While an intermittent incubation with E2 caused no change in amplification of the glutamate-evoked GnRH release for 4 h, continuous incubation with E2 or o,p'-DDT caused an increase of this amplification after 3.5 h of incubation. In summary, DDT amplifies the glutamate-evoked GnRH secretion in vitro through rapid and slow effects involving ER, AHR, and AMPA receptor mediation.

Disciplines :

Environmental sciences & ecology
Anatomy (cytology, histology, embryology...) & physiology

Author, co-author :

Rasier, Gregory ; Université de Liège - ULiège > Département des sciences cliniques > Pédiatrie

Parent, Anne-Simone ; Université de Liège - ULiège > Département des sciences cliniques > Pédiatrie

Gerard, Arlette ; Centre Hospitalier Universitaire de Liège - CHU > Pédiatrie

Denooz, Raphael ; Centre Hospitalier Universitaire de Liège - CHU > Toxicologie clinique

Lebrethon, Marie-Christine ; Centre Hospitalier Universitaire de Liège - CHU > Pédiatrie

Charlier, Corinne ; Université de Liège - ULiège > Département de pharmacie > Chimie toxicologique

Bourguignon, Jean-Pierre ; Université de Liège - ULiège > Département des sciences cliniques > Pédiatrie - IFRES

Language :

English

Title :

Mechanisms of Interaction of Endocrine-Disrupting Chemicals with Glutamate-Evoked Secretion of Gonadotropin-Releasing Hormone

Publication date :

March 2008

Journal title :

Toxicological Sciences

ISSN :

1096-6080

eISSN :

1096-0929

Publisher :

Oxford University Press, United Kingdom

Volume :

102

Issue :

Pages :

33-41

Peer reviewed :

Peer Reviewed verified by ORBi

Funders :

DG RDT - Commission Européenne. Direction Générale de la Recherche et de l'Innovation
BSGPE - Belgian Study Group for Pediatric Endocrinology
Fonds Léon Fredericq

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since 23 August 2010

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