[en] Cataract surgery is the most frequently performed surgical intervention, pursued by replacement of the opacified natural lens by a polymeric intraocular lens (IOL). This paper, based on an exhaustive number of scientific references, provides a brief simplified discussion of the surgical advances for cataract treatment, and is mainly focused on the process of IOL discovery, engineering and development. The performances of the polymer materials, used for the IOLs fabrication are discussed in a comparative way, and their properties, such as handling during surgery, biocompatibility, rate of some post-surgical complications (e.g. Posterior Capsular Opacification) and optical properties, are considered.
Special attention is paid on the basic scientific approaches for engineering and modification of the IOL surface and bulk properties. Polymer coating techniques like ‘grafting onto’ and ‘grafting from’ are discussed and exemplified by a variety of coating compositions and performances.
In another part of the review, modification techniques concerning optimization of the bulk properties of the polymer lens are also discussed and synthetic approaches such as copolymerization and nanocomposite formation are considered. A perspective aspect of this discussion concerns improvement of the performance of the main polymer by the incorporation of in situ formed or preformed nanoparticles.
The most attractive perspectives concerning the improvement of the IOL properties by chemical modification approaches are described.
Research Center/Unit :
Center for Education and Research on Macromolecules (CERM)
Disciplines :
Chemistry Materials science & engineering
Author, co-author :
Bozukova, Dimitriya; Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Pagnoulle, Christophe; Physiol SA, Belgium
Jérôme, Robert ; Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Jérôme, Christine ; Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Language :
English
Title :
Polymers in modern ophthalmic implants—Historical background and recent advances
B. Mutlu Course: Intraocular Lenses 2002 Middle East University, Biotechn. Res. Unit
L. Dumaine. Thesis: Corrélation entre les propriétés physico-chimiques de polymres permettant de moduler la prolifération cellulaire et celles permettant de favoriser le glissement de lentilles intraoculaires, Ecole Centrale de Lyon, 2004, pp. 79-85.
R. Linnola. Academic dissertation: The Sandwich theory: a bioactivity based explanation for Posterior Capsular Opacification after cataract surgery with intraocular lens implantation, Faculty of Medicine, University of Oulu, Finland, 2001.
R.J. Linnola, L. Werner, S.K. Pandey, M. Escobar-Gomez, S.L. Znoiko, and D.J. Apple J. Cataract Refract. Surg. 26 2000 1792 1806
R. Linnola, J.I. Salonen, and R.P. Happonen J. Cataract Refract. Surg. 25 1999 1480 1485
R.J. Linnola J. Cataract Refract. Surg. 24 1998 1509 1514
R.A. Weale J. Physiol. 395 1988 577 587
S. Zigman H. Maisel, The Ocular Lens: Structure, Function and Pathology 1985 Academic Press London 117 150
K.R. Hightower Curr. Eye Res. 14 1994 71 78
Y. Hiratsuka, K. Ono, and A. Kanai Nippon Ganka Gakkai Zasshi 105 6 2001 369 373
N. Azzam, D. Levanon, and A. Dovrat Exp. Gerontol. 39 2004 139 146
M. Linetsky, H.L. James, and B.J. Ortwerth Exp. Eye Res. 63 1996 67 74
Y. Solberg, M. Rosner, and M. Belkin Surv. Ophthalmol. 42 6 1998 535 547
J. Van den Brule, F. Degueldre, and A. Galand Rev. Méd. Liége 53 12 1998 766 769
J.J. Harding Ageing Res. Rev. 1 3 2002 465 479
W. Schalch, and L.T. Chylack Ophthalmologe 100 3 2003 3023 3028
S. Krag, K. Thim, and L. Corydon J. Cataract Refract. Surg. 23 1 1997 86 90
A.R. Vasada, S.M. Raj, K. Johar, and M.A. Nanavaty J. Cataract Refract. Surg. 32 1 2006 145 150
I.H. Fine, M. Packer, and R.S. Hoffman Refractive Lens Surgery 2005 Springer-Verlag Berlin Heidelberg pp. 151-160
C.D. Kelman Am. J. Ophthalmol. 64 1 1967 23 35
M. Prost Klin. Oczna. 97 9-10 1995 308
S. Scholtz Cataract. Refract. Surg. Today Eur. I September/November 2006 61 62
R. Markham Br. J. Ophthalmol. 90 2006 251
D.J. Apple, and J. Sims Surv. Ophthalmol. 40 4 1996 279 292
E.J. Hollick Optometry 2 November 2001 28 33
H. Kecová, and A. Neas Acta. Vet. Brno 73 2004 85 92
H.C. Seward Br. J. Ophthalmol. 81 1997 340 341
E. McLoone, G. Mahon, D. Archer, and R. Best Br. J. Ophthalmol. 85 2001 543 545
K. Shanmugananda Murthy, and N. Ravi Curr. Eye Res. 22 5 2001 384 393
A.S. Hoffman Ann. N. Y. Acad. Sci. 944 2001 62 73
G.D. Barrett Dev. Ophthalmol. 22 1991 70 71
R. Parker Aust. J. Ophthalmol. 7 1979 229 231
H. Larkin Eurotimes March 2006
S. Saika Prog. Retin. Eye Res. 23 2004 283 305
D. Tognetto, L. Toto, E. Ballone, and G. Ravlico J. Cataract Refract. Surg. 28 2002 644 651
C. Parsons, D.S. Jones, and S.P. Gorman Expert Rev. Med. Devices 2 2 2005 161 172
R.H. Trivedi, L. Werner, D.J. Apple, S.K. Pandey, and A.M. Izak Eye 16 2002 217 241
A. Scaramuzza, G.T. Fernando, and B.B. Crayford J. Cataract Refract. Surg. 27 7 2001 1047 1054
D.A. Schaumberg, D.A. Dana, W.G. Christen, and R.J. Glynn Ophthalmology 105 7 1998 1213 1221
D.J. Apple, and F. Rabb D.J. Apple, M.F. Rabb, Ocular Pathology 1998 Mosby St. Louis, Missouri
R.J. Linnola, M. Sund, R. Ylönen, and T. Pihlajaniemi J. Cataract Refract. Surg. 29 2003 146 152
R.J. Linnola, L. Werbner, S.K. Pandey, M. Escobar-Gomez, S.L. Znoiko, and D.J. Apple J. Cataract Refract. Surg. 26 2000 1792 1806
I.M. Nauhann, L. Werner, A.M. Izak, S.K. Pandey, G. Kleinmann, N. Mamalis, T.F. Neuhann, and D.J. Apple Ophthalmology 111 11 2004 2094 2101
P. Versura, A. Torreggiani, M. Cellini, and R. Caramazza J. Cataract Refract. Surg. 25 1999 527 533
J.D. Andrade, and V. Hlady Adv. Polym. Sci. 79 1986 1 63
P. Bernabeu, and A. Caprani Biomaterials 11 1990 258 264
J.P. Kappelhof, J.H. Pameyer, and P.T.V.M. DeJong Am. J. Ophthalmol. 102 1986 750 758
R. Kanagawa, S. Saika, and S. Ohmi Graefes Arch. Clin. Exp. Ophthalmol. 228 1990 398 400
W. Boyd, R.L. Peiffer, G. Siegal, and D.E. Eifrig J. Cataract Refract. Surg. 18 1992 180 183
H.H. Kochounian, S.A. Kovacs, and J. Sy Arch. Ophthalmol. 112 1994 395 401
S. Saika, S. Kobata, and O. Yamanaka Graefes Arch. Clin. Exp. Ophthalmol. 231 1993 718 721
S. Saika, S. Tanaka, and S. Ohmi Graefes Arch. Clin. Exp. Ophthalmol. 235 1997 241 247
S. Saika, S. Ohmi, and A. Ooshima Graefes Arch. Clin. Exp. Ophthalmol. 235 1997 517 522
S. Saika, Y. Kawashima, and T. Miyamoto J. Cataract Refract. Surg. 24 1998 1266 1270
S. Saika, A. Yamanaka, and S. Tanaka Exp. Eye Res. 61 1995 713 721
S. Saika, Y. Kawashima, and T. Miyamoto Exp. Eye Res. 66 1998 283 294
T. Ishibashi, H. Araki, and S. Sugai Ophthalmic Res. 27 1995 208 213
S. Saika, M. Tamura, and K. Uenoyama J. Cataract Refract. Surg. 18 1992 195 199
T. Ishibashi, T. Hatae, and H. Inomata J. Cataract Refract. Surg. 20 1994 643 646
B.D. Ratner, T. Horbett, A.S. Hoffmann, and S.D. Hauschka J. Biomed. Mater. Res. 9 1975 407 422
M. Amon J. Cataract Refract. Surg. 27 2001 178 179
H.H. Kochounian, W.A. Maxwell, and A. Gupta J. Cataract Refract. Surg. 17 1991 139 142
B.D. Ratner, and N.B. Mateo Ophthalmol. Clin. North Am. 4 1991 277 293
B.D. Ratner Arch. Ophthalmol. 101 1983 1434 1438
D.W. Meltzer Arch. Ophthalmol. 98 1980 100 104
D.J. Apple, N. Mamalis, K. Loftfield, J.M. Googe, L.C. Novak, D. Kavka-Va Norman, S.E. Brady, and R.J. Olson Surv. Ophthalmol. 29 1 1984 1 54
P.J. McDonnell, M.A. Zarbin, and W.R. Green Ophthalmology 90 12 1983 1548 1553
Z. Javdani Sanatgar Moghaddam, M.M.A.V. Huygens, and F. Callebaut Bull. Soc. Belge Ophthalmol. 283 2002 13 17
C.M. Haus, and A.L. Galand Br. J. Ophthalmol. 80 1996 1087 1091
S.K. Pandey, B. Cochener, and D.J. Apple J. Cataract Refract. Surg. 28 1 2002 139 148
U.U. Innan, F. Ozturk, and S. Kaynak Graefe's Arch. Clin. Exp. Ophthalmol. 239 9 2001 693 697
N. Yamakawa, T. Tanaka, M. Shigeta, M. Hamano, and M. Usui J. Cataract Refract. Surg. 29 2003 367 370
J. Schauersberger, M. Amon, A. Kruger, C. Abela, G. Schild, and J. Kolodjaschna J. Cataract Refract. Surg. 27 2001 1579 1585
T.P. O'Brien Ophthalmologica 217 2003 7 18
D.J. Apple, M.C. Kincaid, N. Mamalis, and R.J. Olson Intraoculer Lenses: Evolution, Design, Complications and Pathology 1989 Williams and Wilkins Baltimore, MD
T. Nagamoto, and G. Eguchi J. Cataract Refract. Surg. 23 1997 866 872
P.L. Davis J. Cataract Refract. Surg. 18 1992 136 139
R. Guthoff, F. Abramo, J. Draeger, and L. Chumbley J. Cataract Refract. Surg. 16 1990 551 558
O. Nishi, and K. Nishi J. Cataract Refract. Surg. 25 1999 521 526
Q. Peng, N. Visessook, D.J. Apple, S.K. Pandey, L. Werner, M. Escobar-Gomez, R. Schoderbek, K. Solomon, and A. Guindi J. Cataract Refract. Surg. 26 2000 198 213
O. Nishi, K. Nishi, and K. Sakanishi Ophthalmic Surg. Lasers 29 1998 587 594
T. Oshika, T. Nagata, and Y. Ishii Br. J. Ophthalmol. 82 1998 549 553
O. Nishi, K. Nishi, and K. Wickström J. Cataract Refract. Surg. 26 2000 1543 1549
A.J. Kruger, J. Schauersberger, C. Abela, G. Schild, and M. Amon J. Cataract Refract. Surg. 26 2000 566 570
S. Sacu, R. Menapace, O. Findi, B. Kiss, W. Buehl, and M. Georgopoulos Am. J. Ophthalmol. 139 2005 696 703
L.G. Vargas, Q. Peng, D.J. Apple, M. Escobar-Gomez, S.K. Pandey, S.N. Arthur, D.S.M. Hoddinott, and J.M. Schmidbauer J. Cataract Refract. Surg. 28 7 2002 1241 1250
E. Holick, D.J. Spalton, and P.G. Ursell Br. J. Ophthalmol. 82 1998 182 1188
N. Mamalis J. Cataract Refract. Surg. 28 2002 1 2
International Dictionary of Medicine and Biology, Vol. 1, NY, New York, Churchill Livingstone, 1986.
D. Klee, and H. Höcker Adv. Polym. Sci. 149 1999 1 57
D.G. Pitts, and J.P. Bergmanson J. Am. Optom. Soc. 60 1989 420 424
H.R. Taylor, S. West, and B. Munoz Arch. Ophthalmol. 110 1992 99 104
M.A. Mainster Br. J. Ophthalmol. 90 2006 784 792
M.A. Mainster Am. J. Ophthalmol. 102 1986 727 732
Infinite refractive index gradient (IRIG) polymers for ocular implant and contact lens application, US patent 2007/000 4863 A1 (2007).
J. Storsberg, A. Laschewski, Polymezusammensetzung mit hohem Brechunsindex, Patent EP 1 792 923 A1 (2007).
B. Hogstrom, B. Lindqvist, P.I. Nilsson, M. Sandberg, UV absorbing lens material, Patent 4795461 (1989).
Ultraviolet absorbing lenses, EP 0488 145 A2 (1992).
P. Reddy, X. Gao, R. Barnes, C. Fairchild, K. Boci, C. Waycaster, and C. Pashos Curr. Med. Res. Opin. 22 7 2006 1311 1318
L.C. Castro, C.E.B. De Souza, E.S. Soriano, L.A.S. Melo Jr., and A. Paranhos Jr. Arq. Bras. Oftalmol. 69 5 2006 725 729
P. Hawse Br. J. Ophthalmol. 90 2006 939 940
C.R.M. Pagnoulle, Composition a agent chromophore jaune pour lentilles intraocculaires et leintille ainsi obtenues, Patent 1016409A3 (2005).
T. Akira, N. Kazuhiko, Polymerizable UV absorptive dye stuff for lens for eye and lens material for eye using this dye stuff, Patent JP 2 232 056 (A) (1990).
E.A. Boettner, and J.R. Wolter Invest. Ophthalmol. 1 1962 776 783
J.T. Holladay Eurotimes 24 September 2007
S. Zhou ICBRO Annual Meeting Abstracts 2007 10
D.M. Noble ICBRO Annual Meeting Abstracts 2007 11
S. Raghava, G. Goel, and U.B. Kompella J. Tombran-Tink, C.J. Barnstble, Ophthalmology Research: Ocular Transporters in Ophthalmic diseases and Drug Delivery 2008 Humana Press Totowa, NJ 415 435
W. Caseri Macromol. Rapid Commun. 21 2000 705 722
G. Kickelbick Prog. Polym. Sci. 28 2003 83 114
H. Althues, J. Henle, and S. Kaskel Chem. Soc. Rev. 36 2007 1454 1465
N. Ravi, Hydrogel nanocomposites for ophthalmic applications, US patent 0 269 488 A1 (2007).
K. Mentak, A. Keslinke, K. Phan, Nanohybrid polymers for ophthalmic applications, Patent 063 139 A2 (2006).
B. Roszek, W.H. de Jong, R.E. Geertsma, Nanotechnology in medical applications: state-of-the-art in materials and devices, RIVM report 265001001 (2005).
N. Ravi, H.A. Aliyar, and P.D. Hamilton Die Makromol. Chem. Macromol. Symp. 227 2005 191 201
A. Okada, and A. Usuki Mater. Sci. Eng. C3 1995 109 115
D. Porter, E. Metcalfe, and M.J.K. Thomas Fire Mater. 24 2000 45 52
M. Zanetti, S. Lomanik, and G. Camino Macromol. Mater. Eng. 279 2000 1 9
S.P. Armes Polym. News 20 1995 233 237
D.Y. Godovski Adv. Polym. Sci. 119 1995 79 122
C. Lü, Z. Cui, Y. Wang, Z. Li, C. Guan, B. Yang, and J. Shen J. Mater. Chem. 13 2003 2189 2195
H. Althues, R. Palkovits, A. Rumplecker, P. Simon, W. Sigle, M. Bredol, U. Kynast, and S. Kaskel Chem. Mater. 18 2006 1068 1072
W. Müller-Lierheim, Optical elements, especially eye implants, Patent WO 001 278 A2 (2003).
C. Lü, Z. Cui, Z. Li, B. Yang, and J. Shen J. Mater. Chem. 13 2003 526 530
A.J. Kinloch, Chapman and Hall, London, 1987.
H. Salmang, and H. Scholze Keramik (Part I) 1982 Springer Berlin
T. Kyprianidou-Leodidou, P. Margraf, W. Caseri, U.W. Suter, and P. Walther Polym. Adv. Technol. 8 1997 505 512
R.J. Nussbaumer, W.R. Caseri, P. Smith, and T. Tervoort Macromol. Mater. Eng. 288 2003 44 49
V. Khrenov, M. Klapper, M. Koch, and K. Mullen Macromol. Chem. Phys. 206 2005 95 101