Reference : Les anticorps monoclonaux en transplantation rénale
Scientific journals : Article
Human health sciences : Urology & nephrology
Les anticorps monoclonaux en transplantation rénale
Bonvoisin, Catherine mailto [Université de Liège - ULiège > > Néphrologie >]
Weekers, Laurent mailto [Université de Liège - ULiège > > Néphrologie >]
Grosch, Stéphanie mailto [Université de Liège - ULiège > > Néphrologie >]
Krzesinski, Jean-Marie mailto [Université de Liège - ULiège > > Néphrologie >]
Revue Médicale de Liège
Hopital de Baviere
Yes (verified by ORBi)
[en] Immunosuppressive therapy ; Renal transplantation ; Monoclonal antibody ; Basiliximab ; Daclizumab ; Alemtuzumab ; Renal graft rejection
[en] Renal transplantation is the best treatment for end-stage renal disease, but requires efficient immunosuppressive therapy. The latter has evolved over recent years with the development of more powerful drugs and of monoclonal antibodies with very specific target. The first monoclonal antibodies, acting against the interleukin 2 receptor, named basiliximab and daclizumab, have showed an excellent tolerance profile and efficacy to reduce acute graft rejection. However, in spite of these properties, the development of delayed graft function or the graft and patient survivals at 1 year were not modified by the use of such specific treatment. One potential advantage could yet be a decreasing need for corticosteroids and sometimes calcineurin inhibitors which could provide some long term benefits for the renal graft, but also the patient. Alemtuzumab, another monoclonal antibody, aimed at the membrane glycoprotein CD52, can also decrease the incidence of acute rejection and the depth of the required immunosuppressive therapy. Other antibodies are still in development with some interesting preliminary results which however demand confirmation in larger studies.
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