The erythrocyte sodium - potassium cotransport in hypertensive patients: advantages and limitations

[en] The Na-K cotransport activity was measured in erythrocytes of 123 normotensive and 92 hypertensive patients, using the methodology described by Dagher and Garay. Large overlap of the values obtained in the two populations is observed, in such a way this laboratory test cannot be applied for the discrimination between primary and secondary hypertension. Moreover, the abnormalities described for the Na-K cotransport do not appear specific for primary hypertension. In this study, the influence of hypertensive heredity, but also obesity on this cotransport system could not be demonstrated. However, this transport activity is significantly decreased in patients with chronic renal failure, during treatment with oestro-progestatives or during the oestrogenic phase of the menstrual cycle. These data strongly suggest that the cotransport activity could be modified not only by the hypertensive familial predisposition but also by environmental and hormonal influences.

Disciplines :

Urology & nephrology

Author, co-author :

Krzesinski, Jean-Marie ; Université de Liège - ULiège > Néphrologie

Rorive, Georges ; Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques

Language :

English

Title :

The erythrocyte sodium - potassium cotransport in hypertensive patients: advantages and limitations

Publication date :

1985

Journal title :

Clinical and Experimental Hypertension. Part A, Theory and Practice

ISSN :

0730-0077

Publisher :

Marcel Dekker, New York, United States - New York

Volume :

Issue :

Pages :

553-572

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 13 August 2010

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Bibliography

Adragna N., Canessa M., Bize I., Garay R., Tostesone D.C. (1980) (Na-K) cotransport and cell volume in human red blood cells” (abstract). Fed. Proc. 39:1842.
Canessa M., Bize I., Solomon H., Adragna N., Tostesone D., Dagher G., Garay R., Meyer P. (1981) Na+countertransport and cotransport in human red cells: function, dysfunction and genes in essential hypertension” Clin. Exp. Hypert. 3:871.
Cusi D., Barlassina C., Ferrandi M., Lupi P., Frrari P., Bianchi G. (1981) Familial aggregation of cation transport abnormalities and essential hypertension” Clin. Exp. Hypert. 3:871.
Dagher G., Garay R. (1980) A Na+-K+cotransport assay for essential hypertension” Can. J. Biochem. 58:1069.
Davidson J.S., Opie L.H., Keding B. (1982) Sodium-potassium cotransport activity as a genetic marker in essential hypertension. B.M.J. 284:539.
De Luise M., Blackburn G., Flier J. (1980) Reduced activity of the red cell sodium-potassium pump in human obesity” New Engl. J. Med. 303:1017.
Duhm J., Gobel B.O. (1982) Sodium-lithium exchange and sodiumpotassium cotransport in human erythrocytes. Part 1. Evaluation of a simple uptake test to assess the activity of the two transport systems. Hypertension 4:468.
Duhm J., Gobel B., Lorenz R., Weber P. (1982) Sodium-lithium exchange and sodium-potassium cotransport in human erythrocytes. Part 2. A simple uptake test applied to normotensive and essential hypertensive individuals. Hypertension 4:477.
Garay R., Garrahan P. (1973) The interaction of sodium and potassium with the sodium pump in red cells. J. Physiol. 231:297.
Garay R., Meyer P. (1979) A new test showing abnormal net Na+“d K fluxes in erythrocytes of essential hypertensive patients. Lancet 349.
Garay R., Dagher G., Meyer P. (1980) An inherited sodium ionpotassium ion cotransport defect in essential hypertension. Clin. Sci. 59:191s.
Garay R., Elghozi J.L., Dagher G., Meyer P. (1980) Laboratory distinction between essential and secondary hypertension by measurement of erythrocyte cation fluxes” New Engl. J. Med. 302:769.
Garay R., Hannaert P., Dagher G., Nazaret C., Maridonneau I., Meyer P. (1981) Abnormal erythrocyte Na+-K+transport system: a proposed genetic marker of essential hypertension” Clin. Exp. Hypert. 3(4):851.
Garay R., Adragna N., Canessa M., Tostesone D.C. (1981) Outward sodium and potassium cotransport in human red cells. J. Memb. Biol. 62:169.
Garay R., Nazaret G., Hannaert P., Price M. (1983) Abnormal Na+-K +cotransport function in a group of patients with essential hypertension” Europ. J. Clin. Invest. 13:311.
Ghione S., Buzzigoli G., Bartolini V., Balzan S., Donato L. (1981) Comparison of outward and inward Na-K cotransport mediated fluxes in erythrocytes of essential hypertensive patients” Clin. Exp. Hypert. 3(4):809.
Krzesinski J.M., Rorive G.L. (1983) Perturbation of the Na-Li countertransport in red cells. Letter to Editor New Engl. J. Med. 309:987.
(1959) New weight standards for men and women. Statis. Bull. , Metropolitain Life insurance Company new York; 40:1.
Postnov Y., Orlov S., Shevchenko A., Adler A. (1977) Altered sodium permeability, calcium binding and Na+-K+Pase activity in the red blood cell membrane in essential hypertension. Pflügers Arch. 371:263.
Smith J., Ash O., Hentschel W., Worley R., Astle C., Williams R. (1982) Sodium-lithium countertransport in erythrocytes of pregnant women” Letter to Editor New Engl. J. Med. 307(20):1645.
Swarts H., Bonting S., Depont J., Schuurman S., Stekhoyen F., Thien T., N'laar A.I. (1981) Cation fluxes (Na+-K+) activated ATPase activity in erythrocytes of patients with essential hypertension Clin. Exp. Hypert. 3:831.
Villamil M., Rettori V., Kleeman C. (1968) Sodium transport by red blood cells in uremia. J. Lab. and Clin. Med. 72(2):308.
Welt L., Sachs J., Mc Manus T.I. (1964) An ion transport defect in erythrocytes from uremic patients” Trans Ass. Amer. Phys. 77:169.
Yawata Y., Jacobs H. (1975) Abnormal red cell metabolism in patients with chronic uremia: nature of the defect and its persistance despite adequate hemodialysis. Blood 45:231.