Reference : The erythrocyte sodium - potassium cotransport in hypertensive patients: advantages a...
Scientific journals : Article
Human health sciences : Urology & nephrology
The erythrocyte sodium - potassium cotransport in hypertensive patients: advantages and limitations
Krzesinski, Jean-Marie mailto [Université de Liège - ULiège > > Néphrologie >]
Rorive, Georges mailto [Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques >]
Clinical and Experimental Hypertension. Part A, Theory and Practice
Marcel Dekker
Yes (verified by ORBi)
New York
[en] Na-K cotransport ; hypertension ; hypertensive heredity ; obesity ; chronic renal failure ; oestro-progestatives ; menstrual cycle
[en] The Na-K cotransport activity was measured in erythrocytes of 123 normotensive and 92 hypertensive patients, using the methodology described by Dagher and Garay. Large overlap of
the values obtained in the two populations is observed, in such a way this laboratory test cannot be applied for the discrimination between primary and secondary hypertension. Moreover, the abnormalities described for the Na-K cotransport do not appear specific for primary hypertension.
In this study, the influence of hypertensive heredity, but also obesity on this cotransport system could not be demonstrated. However, this transport activity is significantly decreased in patients with chronic renal failure, during treatment with oestro-progestatives or during the oestrogenic
phase of the menstrual cycle. These data strongly suggest that the cotransport activity could be modified not only by the hypertensive familial predisposition but also by environmental and hormonal influences.
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