Reference : Effect of Various 6-Dehydro-Corticosteroids, 9, 11-Dehydro-Doca and 9 Alpha-Fluoro-Do...
Scientific journals : Article
Human health sciences : Urology & nephrology
Effect of Various 6-Dehydro-Corticosteroids, 9, 11-Dehydro-Doca and 9 Alpha-Fluoro-Doca on the Fluxes of Sodium and Potassium
Genard, P. [> > > >]
Palem-Vliers, M. [> > > >]
Christiaens, J. M. [> > > >]
Krzesinski, Jean-Marie mailto [Université de Liège - ULiège > > Néphrologie >]
Hacha, R. [> > > >]
Lomba Pignon, M. R. [> > > >]
Archives Internationales de Physiologie et de Biochimie
Vaillant Carmanne
Yes (verified by ORBi)
[en] corticosteroids ; sodium ; potassium
[en] The introduction of a double bond at carbons 6 and 7 (6-dehydro-derivatives) of deoxycorticosterone acetate (DOCA), cortisol-21-acetate, 9 alpha-fluorocortisol-21-acetate (9 alpha-F-C-ac) and aldosterone-21-acetate substantially reduces affinity for Type II receptors but not for Type I receptors. Such a modification changes the effect of these steroids on urinary excretion of Na+ and K+. 6-Dehydro-derivatives will thus bind preferentially to receptor Type I inducing the retention of sodium and compete with mineralocorticoids for such receptors. The increase in both natriuresis and kaliuresis when corticosteroids and their 6-dehydro-derivatives are administered together may be interpreted as evidence for a Type II receptor mediation of those ion fluxes. The ionic changes are not mediated by the (Na+ + K+)-ATPase system. The fluoration at 9 and the dehydrogenation at C9C11 of DOCA result in a strong increase of binding to Type I receptor and of sodium retention.
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