Reference : How many women can benefit from a full intrapartum antibiotic prphylaxis for preventi...
Scientific congresses and symposiums : Paper published in a book
Human health sciences : Immunology & infectious disease
Human health sciences : Reproductive medicine (gynecology, andrology, obstetrics)
How many women can benefit from a full intrapartum antibiotic prphylaxis for prevention of perinatal group B streptococcal disease?
MELIN, Pierrette mailto [Centre Hospitalier Universitaire de Liège - CHU > > Microbiologie médicale >]
Lorquet, Sophie [> >]
Rodriguez Cuns, Grisel [Universitad de la Republica, Montevideo, Uruguay > > > >]
Foidart, Jean-Michel mailto [Université de Liège - ULiège > Gynécologie Obstétrique > > >]
De Mol, Patrick mailto [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Microbiologie médicale et virologie médicale >]
Program and Abstracts of the 44th Intersciences Conference on Antimicrobial Agents and Chemotherapy
American Society of Microbiology
American Society for Microbiology (ASM)
Abstract du poster G-499
44th Intersciences Conference on Antimicrobial Agents and Chemotherapy (ICAAC)
du 30 octobre au 2 novembre 2004
American Society of Microbiology
[en] Group B streptococci ; perinatal infections ; intrapartum antibiotic prophylaxis ; pregnant women
[en] Background: In Belgium as in many Western countries, GBS are still the leading cause of severe perinatal infections. Current guidelines for prevention recommend intrapartum antimicrobial prohylaxis (IAP)
administered promptly before delivery to pregnant women colonized with GBS. The risk of vertical GBS transmission to the newborn decreases as the duration of prophylaxis increases. The considered threshold for
prophylaxis adequacy is the first dose administered at least 4 hours before delivery.
Objective: To evaluate the proportion of pregnant women who could benefit from an adequate IAP for the prevention of GBS perinatal infections.
Methods: Between June and October 2003, we recorded in two hospitals the elapse time between admission for labor and delivery. We assumed 5 hours represent a useful threshold to allow admission, revision of chart and administration of adequate IAP. The status of vaginal colonization with GBS
was determined by CDC’s recommended culture method with Granada agar added.
Results: Among 532 women, 27.3 % delivered within 5 hours after admission for labor. The colonization rate for GBS was 25.6 %. The distribution of elapse time between admission and delivery for GBS
colonized pregnant women was not significantly different from non colonized women (p <= 1).
Conclusions: 1) With the current prevention strategy, 27.3 % of these pregnant women would not have benefit from adequate prophylaxis 2) These results highlight the importance of an efficient organization to
warranty prompt administration of IAP as soon as possible when mandatory. 3) If a rapid intrapartum screening test is used, no delay can be afforded “from ward to bench to bed”.
Centre National de Référence des Streptocoques du Groupe B

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