[en] Phagocytosis and oxidative burst activity of polymorphonuclear neutrophil leukocytes (PMN) isolated from blood and pregnancy-associated glycoprotein (bPAG) concentrations in plasma were evaluated in two longitudinal studies in dairy cows from 3 weeks before until 5 weeks after calving, carried out in the United States and in Europe. Ingestion of Staphylococcus aureus by blood PMN increased during the first week after calving and normalised 3 weeks post-partum. Phagocytosis of Escherichia coli did not change in the early post-partum period. In both studies, a significant decrease in oxidative burst activity of PMN was observed between 1 and 3 weeks after calving. In all cows, a very significant increase in plasma bPAG concentration was found between 1 week before and 2 weeks after calving. The peak of bPAG concentration in plasma immediately preceded the alterations of blood PMN functions. These results suggest that bPAG may be associated with inhibition of PMN function of dairy cows during the early post-partum period.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Dosogne, H.; University of Ghent - Belgium > Dept of Physiology, Biochemistry and Biometrics
Burvenich, Christian; University of Ghent - Belgium > Dept of Physiology, Biochemistry and Biometrics
Freeman, A. E.; Iowa State University - USA > Dept of Animal Science
Kehrli, Jr; National Animal Disease Center, Metabolic Diseases and Immunology Research Unit > Dept of Agriculture, Agricultural Research Service
Sulon, Joseph ; Université de Liège - ULiège > Département de sciences fonctionnelles > Physiologie de la reproduction
Beckers, Jean-François ; Université de Liège - ULiège > Département de sciences fonctionnelles > Physiologie de la reproduction
Heoben, D.; University of Ghent - Belgium > Dept of Physiology, Biochemistry and Biometrics
Language :
English
Title :
Pregnancy-associated glycoprotein and decreased polymorphonuclear leukocyte function in early post-partum dairy cows
Publication date :
January 1999
Journal title :
Veterinary Immunology and Immunopathology
ISSN :
0165-2427
eISSN :
1873-2534
Publisher :
Elsevier Science, Amsterdam, Netherlands
Volume :
67
Issue :
1
Pages :
47-54
Peer reviewed :
Peer Reviewed verified by ORBi
Name of the research project :
Grant D1/2-5741A; grant 941271
Funders :
Belgian Ministry of Agriculture Flemish Institute for Improvement of Scientific Technological Research in Industry FWO - Fonds Wetenschappelijk Onderzoek Vlaanderen [BE]
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