[en] OBJECTIVE: To describe outcome of treatment with propofol and phenobarbital for status epilepticus (SE) after portosystemic shunt (PSS) attenuation. CASE OR SERIES SUMMARY: Three dogs without preceding seizure activity, were diagnosed with a single extrahepatic PSS. Following standard preoperative medical therapy, an ameroid constrictor was placed surgically. Recovery was uneventful until spontaneous SE developed 46-96 hours after surgery. After unsuccessful seizure control with benzodiazepines, dogs were treated with a bolus of propofol followed by a propofol constant rate infusion. Phenobarbital was concurrently administered and supportive care was optimized. All dogs recovered uneventfully over the next 7-9 days. Over the following months phenobarbital was slowly tapered. All dogs have been free from antiepileptic drugs for several months, without recurrence of neurologic signs. NEW OR UNIQUE INFORMATION PROVIDED: In this case series, we describe the treatment of 3 dogs with propofol and phenobarbital for refractory SE following attenuation of a single congenital PSS. After weaning of the propofol constant rate infusion, and tapering and discontinuation of phenobarbital over the following months, all dogs experienced a complete recovery. This study provides evidence that use of propofol in combination with phenobarbital may be efficacious for management of SE in dogs after PSS surgery.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Gommeren, Kris ; Université de Liège - ULiège > Département clinique des animaux de compagnie et des équidés > Unité des Soins Intensifs
Claeys, Stéphanie ; Université de Liège - ULiège > Département clinique des animaux de compagnie et des équidés > Chirurgie des Animaux de Compagnie
de Rooster, Hilde; Universiteit Gent - Ugent
Hamaide, Annick ; Université de Liège - ULiège > Département clinique des animaux de compagnie et des équidés > Chirurgie des Animaux de Compagnie
Daminet, Sylvie; Universiteit Gent - Ugent
Language :
English
Title :
Outcome from status epilepticus after portosystemic shunt attenuation in 3 dogs treated with propofol and phenobarbital
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