Reference : Early homeostatic disturbances of human growth and maturation by endocrine disrupters
Scientific journals : Article
Human health sciences : Pediatrics
http://hdl.handle.net/2268/67080
Early homeostatic disturbances of human growth and maturation by endocrine disrupters
English
Bourguignon, Jean-Pierre mailto [Université de Liège - ULiège > Département des sciences cliniques > Pédiatrie - IFRES >]
Parent, Anne-Simone mailto [Université de Liège - ULiège > Département des sciences cliniques > Pédiatrie >]
Aug-2010
Current Opinion in Pediatrics
Lippincott Williams & Wilkins
22
4
470-477
Yes (verified by ORBi)
International
1040-8703
1531-698X
Philadelphia
PA
[en] adipogenesis ; energy balance ; nutrition ; puberty ; reproduction ; development
[en] We attempt to delineate and integrate aspects of growth and
development that could be affected by endocrine disrupters [endocrine-disrupting
compounds (EDC)], an increasing public health concern. RECENT FINDINGS:
Epidemiological and experimental data substantiate that fetal and early postnatal
life are critical periods of exposure to endocrine disrupters, with possible
transgenerational effects. The EDC effects include several disorders of the
reproductive system throughout life (abnormalities of sexual differentiation,
infertility or subfertility and some neoplasia) and disorders of energy balance
(obesity and metabolic syndrome). The mechanisms are consistent with the concept
of 'developmental origin of adult disease'. They could involve cross-talk between
the factors controlling reproduction and those controlling energy balance, both
in the hypothalamus and peripherally. SUMMARY: Due to ubiquity of endocrine
disrupters and lifelong stakes of early exposure, individual families should be
provided by pediatricians with recommendations following the precautionary
principle, that is prevention or attenuation of conditions possibly detrimental
to health before the evidence of such adverse effects is complete and
undisputable.
Giga-Neurosciences
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; Commission européenne : Direction générale de la Recherche ; faculty of medicine at the university of Liège ; Belgian study group for pediatric endocrinology
http://hdl.handle.net/2268/67080
10.1097/MOP.0b013e32833a6eef

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