[en] The respiratory tract of the horse can be the seat of several chronic inflammatory diseases whose principal ones are the recurrent airway obstruction, the inflammatory airway disease, the summer pasture-associated obstructive pulmonary disease and the follicular pharyngitis. These diseases can have an important impact on horses’ health and on their sports performances. A good knowledge of their aetiologies and their physiopathological mechanisms would allow a better control of these affections. However, even if many studies were made on this subject, there are currently very few certainties as for the inflammatory mechanisms governing these diseases. This article aims to make an inventory of knowledge and deficiencies concerning these four chronic inflammatory diseases [fr] Le tractus respiratoire du cheval peut être le siège de plusieurs maladies inflammatoires chroniques dont les principales sont la pousse, la maladie inflammatoire des voies respiratoires, le syndrome d’obstruction pulmonaire associé au pâturage en été et la pharyngite folliculaire. Ces maladies peuvent avoir un impact important sur la santé des chevaux mais aussi sur leurs performances sportives. Une meilleure connaissance de leurs étiologies et de leurs mécanismes physiopathologiques permettrait une meilleure maîtrise de ces affections. Cependant, même si de nombreuses études se sont penchées sur le sujet, il existe actuellement très peu de certitudes quant aux mécanismes inflammatoires régissant la plupart de ces maladies. Cet article vise à faire un état des lieux des connaissances et des lacunes concernant ces quatre maladies inflammatoires chroniques
Disciplines :
Anatomy (cytology, histology, embryology...) & physiology Veterinary medicine & animal health
Author, co-author :
Mesnil, Claire ; Université de Liège - ULiège > Département de sciences fonctionnelles > Biochimie et biologie moléculaire
Bureau, Fabrice ; Université de Liège - ULiège > Département de sciences fonctionnelles > Biochimie et biologie moléculaire
Lekeux, Pierre ; Université de Liège - ULiège > Département de sciences fonctionnelles > Physiologie - Doyen de la Faculté de Médecine vétérinaire
Language :
French
Title :
Tableau clinique et mécanismes physiopathologiques des principales maladies inflammatoires chroniques des voies respiratoires du cheval
Alternative titles :
[en] Clinical signs and physiopathological mechanisms of the main chronic inflammatory airway diseases of the horse
AINSWORTH D.M., GRÜNIG G., MATYCHAK M.B., YOUNG J., WAGNER B., ERB H.N., ANTCZAK D.F. Recurrent airway obstruction in horses is characterized by IFN-γ and IL-8 production in bronchoalveolar lavage cells. Vet. Immunol. Immunopathol., 2003, 96, 83-91.
ART T., KIRSCHVINK N., SMITH N., LEKEUX P. Indices of oxidative stress in blood and pulmonary epithelium lining fluid in horses suffering from recurrent airway obstruction. Equine Vet. J., 1999a, 31, 397-401.
ART T., KIRSCHVINK N., SMITH N., VOTION D., LEKEUX P. Cardiorespiratory measurements and indices of oxidative stress in exercising COPD horses. Equine Vet. J., 1999b, 30, 83-87.
ART T., FRANCK T., LEKEUX P., DE MOFFARTS B., COUËTIL L., BECKER M., KOHNEN S., DEBY-DUPONT G., SERTEYN D. Myeloperoxidase concentration in bronchoalveolar lavage fluid from healthy horses and those with recurrent airway obstruction. Can. J. Vet. Res., 2006, 70, 291-296.
AUER D.E., WILSON R.G., GROENENDYK S. Pharyngeal lymphoid hyperplasia in thorough-bred racehorses in training. Aust. Vet. J., 1985, 62, 124-126.
BAICHWAL V.R., BAEUERLE P.A. Activate NF-kappa B or die ? Curr. Biol., 1997, 7, R94-R96.
BAILEY C.J., REID S.W., HODGSON D.R., ROSE R.J. Impact of injuries and disease on a cohort of two-and three-year-old Thoroughbreds in training. Vet. Rec., 1999, 145, 487-493.
BARNES P.J. Pathophysiology of asthma. Br. J. Clin. Pharmacol., 1996, 42, 3-10.
BARNES P.J., CHUNG K.F., PAGE C.P. Inflammatory mediators of asthma: an update. Pharmacol. Rev., 1998, 50, 515-596.
BAYLY W. Lung function: limitations of current methods. In: International workshop on equine chronic airway disease, Michigan State University, 16-17 June 2000. Equine Vet. J., 2001, 33, 5-19.
BONSIGNORE M.R. Inflammatory consequences of exercise. In Proceedings : 3rd World Equine Airways Symposium, Ithaca, USA, 2005, 44-45.
BOUSQUET J., JEFFERY P.K., BUSSE W.W., JOHNSON M., VIGNOLA A.M. Asthma. From bronchoconstriction to airways inflammation and remodelling. Am. J. Respir. Crit. Care Med., 2000, 161, 1720-1745.
BUREAU R., BONIZZI G., KIRSCHVINK N., DELHALLE S., DESMECHT D., MERVILLE M.P., BOURS V., LEKEUX P. Correlation between nuclear factor-kB activity in bronchial brushing samples and lung dysfunction in an animal model of asthma. Am. J. Respir. Crit. Care Med., 2000a, 161, 1314-1321.
BUREAU F., DELHALLE S., BONIZZI G., FIÉVEZ L., DOGNÉ S., KIRSCHVINK N., DESMECHT D., MERVILLE M.P., BOURS V., LEKEUX P. An autocrine mechanism maintains persistent NF-kB activation in the bronchi of an animal model of asthma. Am. J. Respir. Crit. Care Med., 2000b, 160, 1035-1042.
BURRELL M.H., WOOD J.L., WHITWELL K.E.,CHANTER N., MACKINTOSH M.E., MUMFORD J.A. Respiratory disease in thoroughbred horses in training: the relationships between disease viruses, bacteria and environment. Vet. Rec., 1996, 139, 308-313.
CHRISTLEY R.M., HODGSON D.R., ROSE R.J., WOOD J.L., REIDS S.W., WHITEARK.G., HODGSON J.L. A case-control study of respiratory disease in Thoroughbred race-horses in Sydney, Australia. Equine Vet. J., 2001, 33, 256-264.
COOK W.R. Some observations on diseases of the ear, nose and throat in the horse, and endoscopy using a flexible fibreoptic endoscope. Vet. Rec., 1974, 94, 533-541.
CORDEAU M.E., JOUBERT P., DEWACHI O., HAMID Q., LAVOIE J.P. IL-4, IL-5 and IFN-γ mRNA expression in pulmonary lymphocytes in equine heaves. Vet. Immunol. Immunopathol., 2004, 97, 87-96.
COSTAL.R., SEAHORNT.L.,MOORE R.M., TAYLOR H.W., GAUNT S.D., BEADLE R.E. Correlation of clinical score, intrapleural pressure, cytologic findings of bronchoalveolar fluid and histopathologic lesions of pulmonary tissue in horses with summer pastured-associated obstructive pulmonary disease. Am. J. Vet. Res., 2000, 61, 167-173.
COUETIL L.L., DENICOLA D.B., CHILCOAT C.D. Clinical signs, evaluation of bronchoalveolar lavage fluid and assessment of pulmonary function in horses with inflammatory respiratory disease. Am. J. Vet. Res., 2001, 62, 538-546.
DAVIS M.S., FOSTER W.P. Inhalation toxicology in the equine respiratory tract. In: Lekeux P. (Eds.), Equine Respiratory Diseases. Ithaca : International Veterinary Information Service (www.ivis.org), 2002.
DIXON P.M., RAILTON D.I., MCGORUM B.C. Equine pulmonary disease : a case control study of 300 referred cases. Part 3 : Ancillary diagnostic findings. Equine Vet. J., 1995, 27, 428-435.
DONALDSON K., MACNEE W. Ultrafine particle, oxidative stress and lung inflammation. In: Proceedings of the 2nd World Equine Airways Symposium, Edinburgh, Scotland 2001 [en ligne] (juillet 2001) Adresse URL: http://www.ivis.org/proceedings/WEAS/2001/toc.asp consulté le 27/03/07.
ERICKSON H.H., POOLE D.C. Exercice-induced pulmonary haemorrhage. In: Equine Respiratory Diseases, Lekeux P. (Ed.), Ithaca: International Veterinary Information Service (www.ivis.org), 2002.
FINKELMAN F.D., KATONA I.M., URBAN J.F. JR, HOLMES J., OHARA J., TUNG A.S., SAMPLE J.V., PAUL W.E. IL-4 is required to generate and sustain in vivo IgE responses. J. Immunol., 1988, 141, 2335-2341.
GERBER V., KING M., SCHNEIDER D.A., ROBINSON N.E. Mucus viscoelasticity and clearability during environmental challenge in horses with recurrent airway obstruction. Equine Vet. J., 2000, 32, 411-418.
GERBER V., ROBINSONN.E., VENTA P.J., RAWSON J., JEFCOAT A.M., HOTCHKISS J.A. Mucin genes in horse airways: MUC5AC, but not MUC2, may play a role in recurrent airway obstruction. Equine Vet. J., 2003, 35, 252-257.
GIGUERE S., VIEL L., LEE E., MACRAY R.J., HERNANDEZ J., FRANCHINI M. Cytokine induction in pulmonary airways of horses with heaves and effect of therapy with inhaled fluticasone propionate. Vet. Immunol. Immunopathol., 2002, 85, 147-158.
HALLIWELL R.E., MCGORUM B.C., IRVING P, DIXON P.M. Local and systemic antibody production in horses affected with chronic obstructive pulmonary disease. Vet. Immunol. Immunopathol., 1993, 38, 201-215.
HODGSON J.L., HODGSON D.R. Inflammatory airway disease. In: Lekeux P. (Eds.), Equine Respiratory Diseases. Ithaca : International Veterinary Information Service (www.ivis.org), 2002.
HOLCOMBE S.J. Epidemiology of airway inflammation and mucus in horses. In: AAEP Proceedings, Seattle, USA, Internet Publisher: International Veterinary Information Service, Ithaca, NY (www.ivis.org), 2005.
JANEWAY C.A., TRAVERS P., WALPORT M., COPRA J.D. Immunobiology: the immune system in health and disease. 4th edition. Current Biology Publications : London, 1999, 635 p.
KIRSCHVINK N., LEKEUX P. Oxidants and airway inflammation. In Proceedings : 3rd World Equine Airways Symposium, Ithaca, USA, 2005, 35-37.
KLEBANOFF S.J. Myeloperoxidase: friend and foe. J. Leukoc. Biol., 2005, 77, 598-625.
LAVOIE J.P., MAGHNI K., DESNOYERS M., TAHA R., MARTIN J.G., HAMID Q.A. Neutrophilic airway inflammation in horses with heaves is characterised by a Th2-type cytokine profile. Am. J. Respir. Crit. Care Med., 2001, 164, 1410-1413.
LAVOIE J.P., LEGUILLETTE R., PASLOSKE K., CHARRETTE L., SAWYER N., GUAY D., MURPHY T., HICKEY G. Comparison of effects of dexamethasone and the leukotriene D4 receptor antagonist L-708,738 on lung function and airway cytologic findings in horses with recurrent airway obstruction. Am. J. Vet. Res., 2002, 63, 579-585.
LEPPERT D., WAUBANT E., GALARDY R., BUNETT N.W., HAUSER S.L. T cell gelatinases mediate basement membrane transmigration in vitro. J. Immunol., 1995, 154, 4379-4389.
MAIR T.S. Obstructive pulmonary disease in 18 horses at summer pasture. Vet. Rec., 1996, 138, 89-91.
MARTI E., OHNESORGE B. Genetic basis of respiratory disorders. In: Equine Respiratory Diseases, Lekeux P. (Eds.), Ithaca : International Veterinary Information Service (www.ivis.org), 2002.
MATSUKURA S., STELLATO C., PLITT J.R., BICKEL C., MIURA K., GEORAS S.N., CASOLARO V., SCHLEIMER R.P. Activation of eotaxin gene transcription by NF-kappa B and STAT6 in human airway epithelial cells. J. Immunol., 1999, 163, 6876-6883.
McGORUM B.C., DIXON P.M., HALLIWELL R.E.W. Quantification of histamine in plasma and pulmonary fluids from horses with chronic obstructive pulmonary disease, before and after "natural (hay and straw)" challenges. Vet. Immunol. Immunopathol., 1993, 36, 223-237.
McGORUM B.C. Environmental factors as aetiological agents In: International Workshop on Equine Chronic Airway Disease, Michigan State University, 16-17 June 2000. Equine Vet. J., 2001, 33, 5-19.
McGORUM B.C., PIRIE R.S. Aetiological agents: indoor environment and endotoxin. In: Havemeyer Foundation Monograph Series 9. Proceedings of a Workshop on Inflammatory Airway Disease: defining the syndrome. R&W Publications, Newmarket, 2003, 27-28.
MOORE B.R., KRAKOWKA S., ROBERTSON J.T., CUMMINS J.M. Cytologic evaluation of bronchoalveolar lavage fluid obtained from standardbred racehorses with inflammatory airway disease. Am. J. Vet. Res., 1995, 56, 562-566.
MOORE B.R., KRAKOWKA S., McVEY D.S., CUMMINS J.M., ROBERTSON J.T. Inflammatory markers in bronchoalveolar lavage fluid of standardbred racehorses with inflammatory airway disease: response to interferon-alpha. Equine Vet. J., 1997, 29, 142-147.
NEVALAINEN M., RAULO S.M., BRAZIL T.J., PIRIE R.S., SORSA T., McGORUM B.C., MAISI P. Inhalation of organic dusts and lipopolysaccharide increases gelatinolytic matrix metalloproteinases (MMPs) in the lungs of heaves horses. Equine Vet. J., 2002, 34, 150-155.
NEWTON J.R., WOOD J.L.N., SMITH K.C., MARLIN D.J., CHANTER N. Aetiological agents: bacteria. In: Havemeyer Foundation Monograph Series 9. Proceedings of a Workshop on Inflammatory Airway Disease: defining the syndrome. R&W Publications : Newmarket, 2003, 40-44.
O'BYRNE P.M., PERSSON C.G.A., CHURCH M.K. Cellular and mediator mechanisms of the early-phase response. In: Holgates S.T., Church M.K., Lichtenstein L.M. (Eds.), Allergy, 2nd Edn. Mosby : London, 2001, 325-336.
OHNO I., OHTANI H., NITTA Y., SUZUKI J., HOSHI H., HONMA M., ISOYAMA S., TANNO Y., TAMURA G., YAMAUCHI K., NAGURA H., SHIRATO K. Eosinophils as a source of matrix metalloproteinase-9 in asthmatic airway inflammation. Am. J. Respir. Cell. Mol. Biol., 1997, 16, 212-219.
OWEN C.A., CAMPBELL J. The cell biology of leukocyte-mediated proteolysis. J. Leukocyt. Biol., 1999, 65, 137-150.
PIRIE R.S., COLLIE D.D.S., DIXON P.S., McGORUM B.C. Evaluation of nebulised hay dust suspension (HDS) for the diagnosis and investigation of heaves. 2. Effects of inhaled HDS on control and heaves horses. Equine Vet. J., 2002, 34, 337-342.
RAPHEL C.F. Endoscopic findings in the upper respiratory tract of 479 horses. J. Am. Vet. Assoc., 1982, 181, 470-473.
RAKER C.W., BOLES C.L. Pharyngeal lymphoid hyperplasia in the horse. J. Equine Med. Surg., 1978, 2, 202-207.
RAULO S.M., SORSA T., TERVAHARTIALA T., PIRILÄ E., MAISI P. MMP-9 as a marker of inflammation in tracheal epithelial lining fluid (TELF) and in bronchoalveolar fluid (BALF) of COPD horses. Equine Vet. J., 2001, 33, 128-136.
ROBINSON D., HAMID Q., BENTLEY A., YING S., KAY A.B., DURHAM S.R. Activation of CD4+ T cells, increased TH2-type cytokine mRNA expression, and eosinophil recruitment in bronchoalveolar lavage after allergen inhalation challenge in patients with atopic asthma. J. Allergy Clin. Immunol., 1993, 92, 313-324.
ROBINSON N.E., DERKSEN F.J., OLSZEWSKI M., BUECHNER-MAXWELL V.A. The pathogenesis of obstructive pulmonary disease of horses. Br. Vet. J., 1996, 152, 283-306.
ROBINSON N.E. Recurrent airway obstruction. In: Equine Respiratory Diseases, Lekeux P. (Ed.), Ithaca : International Veterinary Information Service (www.ivis.org), 2001.
ROSSDALE P.D., HOPES R., DIGBY N.J., OFFORD K. Epidemiological study of wastage among race-horses 1982 and 1983. Vet. Rec., 1985, 116, 66-69.
RUSH B.R. Inflammatory airway disease: a clinician's view from North America. In: Havemeyer Foundation Monograph Series 9. Proceedings of a Workshop on Inflammatory Airway Disease: defining the syndrome. R&W Publications, Newmarket, 2003, 3-6.
SASSE H. Clinician's perspective of equine airway disease ("heaves) In: International Workshop on Equine Chronic Airway Disease, Michigan State University, 16-17 June 2000. Equine Vet. J., 2001, 33, 5-19.
SEAHORN T.L., GROVES M.G., HARRINGTON K.S., BEADLE R.E. Chronic obstructive pulmonary disease in horses in Louisiana. J. Am. Vet. Med. Assoc., 1996, 208, 248-251.
SHOEMAKER R.S., HAYNES P.F. Pharyngeal lymphoid hyperplasia and pharyngeal stricture. In: Robinson N.E. (Eds.), Current therapy in equine medicine. Saunders WB. : Philadelphia, 1992, 282-283.
SLOCOMBE R. Pathology of the airways In: International Workshop on Equine Chronic Airway Disease, Michigan State University, 16-17 June 2000. Equine Vet. J., 2001, 33, 5-19.
TOWNSEND H.G.G. Natural history of equine influenza. In: Havemeyer Foundation Monograph Series 9. Proceedings of a Workshop on Inflammatory Airway Disease: defining the syndrome. R&W Publications, Newmarket, 2003, 37-39.
TURLEJ R.K., FIEVEZ L., SANDERSEN C.F., DOGNE S., KIRSCHVINK N., LEKEUX P., BUREAU F. Enhanced survival of lung granulocytes in an animal model of asthma: evidence for a role of GM-CSF activated STAT5 signalling pathway. Thorax, 2001, 56, 696-702.
WATSON E.D., SWEENEY C.R., STEENSMA K.A. Arachidonate metabolites in bronchoalveolar lavage fluid from horses with and without COPD. Equine Vet. J., 1992, 24, 379-381.
