[en] The erythrocyte, as an oxygen carrier, is submitted to areas where oxidative stress is important. The maintenance of the structure and fluidity of its membrane is essential to its function. Indeed, oxygen must diffuse through the membrane and the deformability of the cell is essential to its progression through capillaries. The structure and, as a consequence, the fluidity of the membrane influence these properties. The red blood cell presents antioxydant capacities, but in some cases, free radical production is increased and exceeds antiradical defences leading to irreversible defects of the membrane, and, as a consequence, of its function. Horse erythrocyte seems to be more sensitive to oxidative stress than other species and resulting hemorheological changes could have tissular and organic consequences. [fr] Le globule rouge, de par sa fonction de transport de l’oxygène, est soumis à des milieux où le stress oxydant est important. Le maintien de la structure et de la dynamique de sa membrane est essentiel à la réalisation de sa fonction. En effet, l’oxygène doit pouvoir diffuser à travers la membrane et la cellule doit être capable de se déformer pour progresser dans les capillaires. La structure et, en conséquence, la fluidité de la membrane influencent ces propriétés. Le globule rouge présente des défenses antioxydantes importantes, mais dans certaines situations la production de radicaux libres est accrue et dépasse ces défenses aboutissant à des lésions irréversibles de la membrane cellulaire et donc de la fonction. L’érythrocyte équin semble plus sensible au stress oxydant que celui des autres espèces et les modifications hemorhéologiques qui en résultent peuvent avoir des conséquences au niveau tissulaire et organique.
Disciplines :
Anatomy (cytology, histology, embryology...) & physiology Veterinary medicine & animal health
Author, co-author :
Portier, Karine; Ecole Nationale Vétérinaire de Lyon, France > Hippique > Anesthésiologie
Kirschvink, Nathalie; Université de Namur, Belgique > Faculté des Sciences > Laboratoire de Physiologie animale
Fellmann, Nicole; Université d'Auvergne, Clermont Ferrand, France > Faculté de Médecine > Laboratoire de Physiologie et Biologie du Sport
Coudert, Jean; Université d'Auvergne, Clermont Ferrand, France > Faculté de Médecine > Laboratoire de Physiologie et Biologie du Sport
Lekeux, Pierre ; Université de Liège - ULiège > Département de sciences fonctionnelles > Physiologie - Doyen de la Faculté de Médecine vétérinaire
Language :
French
Title :
Paramètres influençant la structure et la fonction du globule rouge chez le cheval
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