De la génétique des adénomes hypophysaires familiaux

pituitary neoplasms/genetics; multiple endocrine neoplasia type 1; aryl hydrocarbon receptor-interacting protein; tumeurs de l'hypophyse/génétique; néoplasie endocrinienne multiple de type 1

Abstract :

[en] Pituitary adenomas were previously thought to be rare. However, a recent cross-sectional study conducted in Liège, Belgium, showed that clinically apparent pituitary adenomas were present in about 1 in 1000 inhabitants, which is 4 to 5 times the previously reported prevalence. Pituitary adenomas are generally sporadic, but some are associated with familial-isolated tumoral syndromes (mainly MEN1 and Carney complex). With the recent characterization of FIPA (Familial Isolated Pituitary Adenomas), familial pituitaru adenomas are now thought to account for 5 % to 8 % of all pituitary tumors. New genetic mechanisms are being identified, improving our understanding of the complex manifestations and sometimes unpredictable outcome of pituitary adenomas.
[fr] Les adénomes hypophysaires étaient autrefois considérés comme rares. Une étude liégeoise récente a cependant montré une prévalence des adénomes hypophysaires cliniquement actifs d'environ un sur mille habitants soit quatre à cinq fois supérieure aux données antérieures. Les adénomes hypophysaires familiaux représentent probablement 5 à 8 % des adénomes hypophysaires. Les principales formes sont la néoplasie endocrinienne de type 1 et le complexe de Carney. La caractérisation clinique et génétique des adénomes familiaux a été récemment enrichie par la description de la nouvelle entité FIPA (Familial Isolated Pituitary Adenomas) et des mutations du gène AIP (Aryl Hydrocarbon Receptor Interacting Protein). D'évolution habituellement bénigne, les adénome hypophysaires sont caractérisés par une grande diversité clinique et génétique qui réclame des moyens diagnostiques et thérapeutiques spécifiques.

Disciplines :

Endocrinology, metabolism & nutrition

Author, co-author :

Beckers, Albert ; Université de Liège - ULiège > Département des sciences cliniques > Endocrinologie

Jaffrain-Rea, M. L.

Daly, Adrian ; Université de Liège - ULiège > Département des sciences cliniques > Endocrinologie

Language :

French

Title :

De la génétique des adénomes hypophysaires familiaux

Alternative titles :

[en] Genetics of familial pituitary adenomas

Publication date :

27 October 2009

Journal title :

Bulletin de l'Académie Nationale de Médecine

ISSN :

0001-4079

eISSN :

2271-4820

Publisher :

Elsevier, Amsterdam, Netherlands

Volume :

193

Issue :

Pages :

1557-1571

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 15 July 2010

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