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Article (Scientific journals)
Serum erythropoietin in chronic lymphocytic leukaemia.
Beguin, Yves; Lampertz, S.; Bron, D. et al.
1996In British Journal of Haematology, 93 (1), p. 154-6
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Keywords :
Adult; Aged; Aged, 80 and over; Erythropoiesis; Erythropoietin/blood; Female; Hemoglobins/analysis; Humans; Leukemia, Lymphocytic, Chronic, B-Cell/blood; Male; Middle Aged; Receptors, Transferrin/analysis
Abstract :
[en] Anaemia is a frequent complication of advanced chronic lymphocytic leukaemia (CLL) and several cytokines known to inhibit erythropoietin (Epo) formation are produced by CLL B cells. Therefore we measured serum Epo levels in 47 CLL patients to determine whether Epo was a significant factor in the development of their anaemia. Epo levels were increased compared to normal individuals and this elevation appeared adequate for the degree of anaemia. The slope of the regression of Epo versus haemoglobin (Hb) was similar to that of a reference group. Serum transferrin receptor (sTfR) levels were also appropriately elevated for the degree of anaemia and correlated with serum Epo. Advanced stage was not associated with reduction of Epo production but diminished erythropoietic activity was observed in several patients. The results indicate that anaemia in CLL is not characterized by inadequate Epo production.
Disciplines :
Hematology
Author, co-author :
Beguin, Yves  ;  Centre Hospitalier Universitaire de Liège - CHU > Hématologie clinique
Lampertz, S.
Bron, D.
Fillet, Georges ;  Centre Hospitalier Universitaire de Liège - CHU > Hématologie clinique
Language :
English
Title :
Serum erythropoietin in chronic lymphocytic leukaemia.
Publication date :
1996
Journal title :
British Journal of Haematology
ISSN :
0007-1048
eISSN :
1365-2141
Publisher :
Blackwell Publishing, Oxford, United Kingdom
Volume :
93
Issue :
1
Pages :
154-6
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 19 February 2009

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