Serum erythropoietin in chronic lymphocytic leukaemia.

Beguin, Yves; Lampertz, S.; Bron, D.; Fillet, Georges

doi:10.1046/j.1365-2141.1996.452992.x

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Serum erythropoietin in chronic lymphocytic leukaemia.

Beguin, Yves; Lampertz, S.; Bron, D. et al.

1996 • In British Journal of Haematology, 93 (1), p. 154-6

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/6619

DOI
10.1046/j.1365-2141.1996.452992.x

PubMed
8611451

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Keywords :

Adult; Aged; Aged, 80 and over; Erythropoiesis; Erythropoietin/blood; Female; Hemoglobins/analysis; Humans; Leukemia, Lymphocytic, Chronic, B-Cell/blood; Male; Middle Aged; Receptors, Transferrin/analysis

Abstract :

[en] Anaemia is a frequent complication of advanced chronic lymphocytic leukaemia (CLL) and several cytokines known to inhibit erythropoietin (Epo) formation are produced by CLL B cells. Therefore we measured serum Epo levels in 47 CLL patients to determine whether Epo was a significant factor in the development of their anaemia. Epo levels were increased compared to normal individuals and this elevation appeared adequate for the degree of anaemia. The slope of the regression of Epo versus haemoglobin (Hb) was similar to that of a reference group. Serum transferrin receptor (sTfR) levels were also appropriately elevated for the degree of anaemia and correlated with serum Epo. Advanced stage was not associated with reduction of Epo production but diminished erythropoietic activity was observed in several patients. The results indicate that anaemia in CLL is not characterized by inadequate Epo production.

Disciplines :

Hematology

Author, co-author :

Beguin, Yves ; Centre Hospitalier Universitaire de Liège - CHU > Hématologie clinique

Lampertz, S.

Bron, D.

Fillet, Georges ; Centre Hospitalier Universitaire de Liège - CHU > Hématologie clinique

Language :

English

Title :

Serum erythropoietin in chronic lymphocytic leukaemia.

Publication date :

1996

Journal title :

British Journal of Haematology

ISSN :

0007-1048

eISSN :

1365-2141

Publisher :

Blackwell Publishing, Oxford, United Kingdom

Volume :

Issue :

Pages :

154-6

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 19 February 2009

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Bibliography

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